The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism
Open accessAbstract
Mercury is one of the most toxic substances known to humans. It has been introduced into the human environment and has also been widely used in medicine. Since circumstantial evidence exists that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by inorganic mercury, we conducted a systematic review using a comprehensive search strategy. Studies were screened according to a pre-defined protocol. Two reviewers extracted relevant data independent of each other. One thousand and forty one references were scrutinized, and 106 studies fulfilled the inclusion criteria. Most studies were case control or comparative cohort studies. Thirty-two studies, out of 40 testing memory in individuals exposed to inorganic mercury, found significant memory deficits. Some autopsy studies found increased mercury levels in brain tissues of AD patients. Measurements of mercury levels in blood, urine, hair, nails, and cerebrospinal fluid were inconsistent. In vitro models showed that inorganic mercury reproduces all pathological changes seen in AD, and in animal models inorganic mercury produced changes that are similar to those seen in AD. Its high affinity for selenium and selenoproteins suggests that inorganic mercury may promote neurodegenerative disorders via disruption of redox regulation. Inorganic mercury may play a role as a co-factor in the development of AD. It may also increase the pathological influence of other metals. Our mechanistic model describes potential causal pathways. As the single most effective public health primary preventive measure, industrial, and medical usage of mercury should be eliminated as soon as possible.
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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
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Self-citationSontag, E., Nunbhakdi-Craig, V., Sontag, J.-M., Diaz-Arrastia, R., Ogris, E., Dayal, S., Lentz, S. R., Arning, E., & Bottiglieri, T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3316-06.2007 · Cited by 225
Cited by
Mercury Toxicity and Treatment: A Review of the Literature
Bernhoft, R. A. (2012) · Journal of Environmental and Public Health · doi:10.1155/2012/460508 · Cited by 1,162
Human Exposure and Health Effects of Inorganic and Elemental Mercury
Park, J.-D., & Zheng, W. (2012) · Journal of Preventive Medicine & Public Health · doi:10.3961/jpmph.2012.45.6.344 · Cited by 770
Trace Elements in Human Nutrition (II)—An Update
Mehri, A. (2020) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_48_19 · Cited by 395
Toxicity of heavy metals in plants and animals and their uptake by magnetic iron oxide nanoparticles
Rehman, A. U., Nazir, S., Irshad, R., Tahir, K., ur Rehman, K., Islam, R. U., & Wahab, Z. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114455 · Cited by 322
The role of metallobiology and amyloid-β peptides in Alzheimer's disease
Roberts, B. R., Ryan, T. M., Bush, A. I., Masters, C. L., & Duce, J. A. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07500.x · Cited by 266
Metadata
- Authors
- Mutter, J., Curth, A., Naumann, J., Deth, R., & Walach, H.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-10-01
- Volume
- 22
- Issue
- 2
- Pages
- 357-374
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2136539949
- Cited by
- 162
- References
- 13
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mutter, J., Curth, A., Naumann, J., Deth, R., & Walach, H. (2010). Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-2010-100705
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