Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Amyloid plaque core protein in Alzheimer disease and Down syndrome.

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α-Synuclein Locus Triplication Causes Parkinson's Disease

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 3,151 · see citing works

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Neurodegenerative Tauopathies

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

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High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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The ubiquitin pathway in Parkinson's disease

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

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Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

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Intraneuronal Aβ42 Accumulation in Human Brain

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

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Reconstitution of γ-secretase activity

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The role of presenilin cofactors in the γ-secretase complex

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

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Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

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Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

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Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

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Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

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Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

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Targeting programmed cell death in neurodegenerative diseases

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