Decoding Parkinson’s Disease Pathogenesis: The Role of Deregulated mRNA Translation
Open accessAbstract
Mutations in a number of genes cause rare familial forms of Parkinson’s disease and provide profound insight into potential mechanisms governing disease pathogenesis. Recently, a role for translation and metabolism of mRNA has emerged in the development of various neurodegenerative disorders including Parkinson’s disease (PD). In PD, preliminary evidence supports a role for aberrant translation in the disease process stemming from mutations in several genes. Translation control is central to maintaining organism homeostasis under variable environmental conditions and deregulation of this may predispose to certain stressors. Hypothetically, deregulated translation may be detrimental to neuronal viability in PD through the misexpression of a subset of transcripts or through the impact of excessive bulk translation on energy consumption and burden on protein homeostatic mechanisms. While compelling preliminary evidence exists to support a role for translation in PD, much more work is required to identify specific mechanisms linking altered translation to the disease process.
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Defects in mRNA translation are linked to autosomal dominant PD and autosomal recessive PD, where there is aberrant bulk protein synthesis coupled to neurodegeneration.
“Defects in mRNA translation are linked to autosomal dominant PD (5,6) and autosomal recessive PD (7), where there is aberrant bulk protein synthesis that is coupled to neurodegeneration (8,9).”
From Enhanced mTORC1 signaling and Protein Synthesis in Parkinson’s Disease Pathogenesis Disease Pathogenesis (2022) · cites this paper as [8]
The ‘Deregulated Translation in Parkinson’s Disease’ section (page unavailable) reports elevated bulk protein synthesis linked to neurodegenerative phenotypes in a mutant LRRK2 fly model. It also links pink1 and parkin pathology to translation, but explicitly says there is no direct evidence that either gene dysregulates global mRNA translation in PD. Thus, the claim extends the bulk-synthesis finding beyond what the paper supports. (LLM, conf=0.88)
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Linking the VPS35 and EIF4G1 Pathways in Parkinson’s Disease
Ross, O. A., Cook, C. N., & Petrucelli, L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.045 · Cited by 31 · see citing works
Delbroek, L., Kolen, K. V., Steegmans, L., da Cunha, R., Mandemakers, W. J., Daneels, G., Bock, P. D., Zhang, J., Gevaert, K., Strooper, B. D., et al. (2012) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2012.12.002 · Cited by 27 · see citing works
Huttenlocher, J., Krüger, R., Capetian, P., Lohmann, K., Brockmann, K., Csóti, I., Klein, C., Berg, D., Gasser, T., von Bonin, M., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102570 · Cited by 26 · see citing works
EIF4G1 mutations do not cause Parkinson's disease
Nichols, N., Brás, J., Hernandez, D. G., Jansen, I. E., Lesage, S., Lubbe, S. J., & Singleton, A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.017 · Cited by 26 · see citing works
Kamikawaji, S., Ito, G., Sano, T., & Iwatsubo, T. (2013) · Biochemistry · doi:10.1021/bi400596m · Cited by 19 · see citing works
Mutations in EIF4G1 are not a common cause of P arkinson's disease
Siitonen, A., Majounie, E., Federoff, M., Ding, J., Majamaa, K., & Singleton, A. (2013) · European Journal of Neurology · doi:10.1111/ene.12051 · Cited by 12 · see citing works
A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity
da Silva, R. G., Geoghegan, K. F., Qiu, X., & AULABAUGH, A. E. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.01.007 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Fernandes, H. J. R., Patikas, N., Foskolou, S., Field, S. F., Park, J.-E., Byrne, M. L., Bassett, A. R., & Metzakopian, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108263 · Cited by 138 · see citing works
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Implications of mRNA translation dysregulation for neurological disorders
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Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection
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Dynamic landscape of the local translation at activated synapses
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Shwab, E. K., Gingerich, D. C., Man, Z., Gamache, J., Garrett, M. E., Crawford, G. E., Ashley‐Koch, A. E., Serrano, G. E., Beach, T. G., Lutz, M. W., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01803-1 · Cited by 27 · see citing works
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Synaptic proteostasis in Parkinson's disease
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Rapid cell type-specific nascent proteome labeling in Drosophila
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Self-citationmRNA isoform balance in neuronal development and disease
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Protein Translation in the Pathogenesis of Parkinson’s Disease
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- Authors
- Martin, I.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Martin, Ian
- ORCID
- Martin, Ian
- Venue
- Journal of Parkinson’s Disease
- Publisher
- SAGE Publications
- Published
- 2016-01-29
- Volume
- 6
- Issue
- 1
- Pages
- 17-27
- ISSN
- 1877-7171 (ISSN-L)
- 1877-718X
- PMC
- PMC4927901
- OpenAlex
- W2310986698
- Cited by
- 23
- References
- 89
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2017: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Parkinson s Disease (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Aging (K01AG050718)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- Parkinson's disease, mRNA translation, translational regulation, familial Parkinson's disease mutations, neurodegeneration, proteostasis, neuronal viability, translational stress, energy consumption
- MeSH terms
- Animals, Humans, Parkinson Disease, RNA, Messenger, Protein Biosynthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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