Spreading of pathology in neurodegenerative diseases: a focus on human studies

Neuropathological stageing of Alzheimer-related changes.

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Staging of brain pathology related to sporadic Parkinson’s disease

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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Novel Proteinaceous Infectious Particles Cause Scrapie

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

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Phases of Aβ-deposition in the human brain and its relevance for the development of AD

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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Neurodegenerative Tauopathies

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The spectrum of disease in chronic traumatic encephalopathy

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

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Transmission and spreading of tauopathy in transgenic mouse brain

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

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Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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100 years of Lewy pathology

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Use of Florbetapir-PET for Imaging β-Amyloid Pathology

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Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

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Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1343-6 · Cited by 925 · see citing works

TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

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Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

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Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

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Prion-like spreading of pathological α-synuclein in brain

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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Exosomal cell-to-cell transmission of alpha synuclein oligomers

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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The pathological process underlying Alzheimer’s disease in individuals under thirty

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Identifying the amylome, proteins capable of forming amyloid-like fibrils

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Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates

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Where Does Parkinson Disease Pathology Begin in the Brain?

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Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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A network diffusion model of disease progression in dementia

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Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

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Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

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Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

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Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

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Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807

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18 F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

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Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

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Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

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TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

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Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

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Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

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Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

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Assembly-dependent endocytosis and clearance of extracellular a-synuclein

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Alpha-synuclein in colonic submucosa in early untreated Parkinson’s disease

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Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system

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The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons

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Transmission of multiple system atrophy prions to transgenic mice

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

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Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia

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Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease

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Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

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Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

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Parkinson's Disease Is Not Simply a Prion Disorder

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Mass spectrometry‐based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders

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Mitophagy and Oxidative Stress: The Role of Aging

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Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

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Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit

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Transmission of tauopathy strains is independent of their isoform composition

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The Future of Nuclear Medicine, Molecular Imaging, and Theranostics

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PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.

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Cellular and Molecular Mechanisms of Prion Disease

Sigurdson, C. J., Bartz, J. C., & Glatzel, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-013109 · Cited by 171 · see citing works

Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease

Johnstone, D. M., Moro, C., Stone, J., Benabid, A., & Mitrofanis, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00500 · Cited by 171 · see citing works

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

Iaccarino, L., Tammewar, G., Ayakta, N., Baker, S. L., Bejanin, A., Boxer, A. L., Gorno-Tempini, M. L., Janabi, M., Kramer, J. H., Lazaris, A., et al. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.09.016 · Cited by 165 · see citing works

The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders

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Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

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Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

Walsh, D. M., & Selkoe, D. J. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.003 · Cited by 160 · see citing works

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

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Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls

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MicroRNAs in Microglia: How do MicroRNAs Affect Activation, Inflammation, Polarization of Microglia and Mediate the Interaction Between Microglia and Glioma?

Guo, Y.-W., Hong, W., Wang, X., Zhang, P., Körner, H., Tu, J., & Wei, W. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00125 · Cited by 153 · see citing works

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

Ivanova, M. I., Lin, Y., Lee, Y., Zheng, J., & Ramamoorthy, A. (2020) · Biophysical Chemistry · doi:10.1016/j.bpc.2020.106507 · Cited by 153 · see citing works

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

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Structural and functional properties of prefibrillar α-synuclein oligomers

Pieri, L., Madiona, K., & Melki, R. (2016) · Scientific Reports · doi:10.1038/srep24526 · Cited by 145 · see citing works

Cell-to-Cell Transmission of Tau and α-Synuclein

Uemura, N., Uemura, M. T., Luk, K. C., Lee, V. M. ‐., & Trojanowski, J. Q. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.012 · Cited by 141 · see citing works

Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances

Gupta, V. B., Chitranshi, N., den Haan, J., Mirzaei, M., You, Y., Lim, J. K. H., Basavarajappa, D. K., Godinez, A., Angelantonio, S. D., Sachdev, P. S., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100899 · Cited by 143 · see citing works

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

Davidsson, M., Wang, G., Aldrin-Kirk, P., Cardoso, T., Nolbrant, S., Hartnor, M., Mudannayake, J., Parmar, M., & Björklund, T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910061116 · Cited by 142 · see citing works

Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis

Ciurea, A. V., Mohan, A. G., Covache-Busuioc, R.-A., Costin, H. P., Glavan, L.-A., Corlatescu, A.-D., & Saceleanu, V. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310809 · Cited by 149 · see citing works

The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes

Buchholz, S., & Zempel, H. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13784 · Cited by 145 · see citing works

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Brás, I. C., & Outeiro, T. F. (2021) · Cells · doi:10.3390/cells10020375 · Cited by 136 · see citing works

Natural Tripeptide-Based Inhibitor of Multifaceted Amyloid β Toxicity

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Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

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Propagation of Pathology through Brain Networks in Neurodegenerative Diseases: From Molecules to Clinical Phenotypes

Agosta, F., Weiler, M., & Filippi, M. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12410 · Cited by 56 · see citing works

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

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Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease

Pearce, M. M. P. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.03.011 · Cited by 19 · see citing works

Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases

Yoshida, S., & Hasegawa, T. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105307 · Cited by 9 · see citing works