The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Cancer Epigenetics
Open accessAbstract
Epigenetics refers to stable alterations in gene expression with no underlying modifications in the genetic sequence and is best exemplified by differentiation, in which multiple cell types diverge physiologically despite a common genetic code. Interest in this area of science has grown over the past decades, especially since it was found to play a major role in physiologic phenomena such as embryogenesis, imprinting, and X chromosome inactivation, and in disease states such as cancer. The latter had been previously thought of as a disease with an exclusive genetic etiology. However, recent data have demonstrated that the complexity of human carcinogenesis cannot be accounted for by genetic alterations alone, but also involves epigenetic changes in processes such as DNA methylation, histone modifications, and microRNA expression. In turn, these molecular alterations lead to permanent changes in the expression of genes that regulate the neoplastic phenotype, such as cellular growth and invasiveness. Targeting epigenetic modifiers has been referred to as epigenetic therapy. The success of this approach in hematopoietic malignancies validates the importance of epigenetic alterations in cancer, not only at the therapeutic level but also with regard to prevention, diagnosis, risk stratification, and prognosis.
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Cites
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Cited by
Non-coding RNAs and cancer: microRNAs and beyond
Raia, R. M., & Calin, G. A. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.e5 · Cited by 3,382
Aging and epigenetic drift: a vicious cycle
Issa, J.-P. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69735 · Cited by 419
Self-citationEndometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications
Monteiro, J. B., Colón-Díaz, M., García, M., Gutierrez, S., Colón, M., Seto, E., Laboy, J., & Flores, I. (2014) · Reproductive Sciences · doi:10.1177/1933719113497267 · Cited by 98
MicroRNAs as therapeutic targets and their potential applications in cancer therapy
Cho, W. C. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.696102 · Cited by 70
Metadata
- Authors
- Taby, R., & Issa, J.-P. J.
- Venue
- CA: A Cancer Journal for Clinicians
- Publisher
- Wiley
- Published
- 2010-10-20
- Volume
- 60
- Issue
- 6
- Pages
- 376-392
- ISSN
- 0007-9235 (ISSN-L)
- OpenAlex
- W3190412754
- Cited by
- 407
- References
- 19
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
