The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mesenchymal stem cells: the fibroblasts' new clothes?
Open accessAbstract
Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability to differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress immune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile. Despite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood. Particularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different anatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate appear to be common features between these two cell types. In this review, we summarize recent studies in the context of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and fibroblasts share much more in common than previously recognized.
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Gargett, C. E., Schwab, K. E., & Deane, J. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv051 · Cited by 561
Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095919 · Cited by 462
Bone Marrow Mesenchymal Stem Cells: Historical Overview and Concepts
Charbord, P. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.115 · Cited by 441
Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421
The decisive early phase of bone regeneration
Duda, G. N., Geissler, S., Checa, S., Tsitsilonis, S., Petersen, A., & Schmidt-Bleek, K. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00887-0 · Cited by 409
Metadata
- Authors
- Haniffa, M. A., Collin, M. P., Buckley, C. D., & Dazzi, F.
- Venue
- Haematologica
- Published
- 2008-12-23
- Volume
- 94
- Issue
- 2
- Pages
- 258-263
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- OpenAlex
- W2156765200
- Cited by
- 345
- References
- 10
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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