Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Open accessAbstract
Because inflammation is appreciated as a unifying basis of many widely occurring diseases, the mechanisms involved in its natural resolution are of considerable interest. Using contained, self-limited inflammatory exudates and a systems approach, novel lipid-derived mediators and pathways were uncovered in the resolution of inflammatory exudates. These new families of local mediators control both the duration and magnitude of acute inflammation as well as the return of the site to homeostasis in the process of catabasis. This new genus of specialized proresolving mediators (SPM) includes essential fatty acid-derived lipoxins, resolvins, protectins, and, most recently, maresins. These families were named based on their unique structures and potent stereoselective actions. The temporally initiated biosynthesis of SPM and their direct impact on leukocyte trafficking and macrophage-directed clearance mechanisms provide clear evidence that resolution is an active, programmed response at the tissue level. Moreover, SPM that possess anti-inflammatory (ie, limiting PMN infiltration) and proresolving (enhance macrophage uptake and clearance of apoptotic PMN and microbial particles) actions as well as stimulating mucosal antimicrobial responses demonstrate that anti-inflammation and proresolution are different responses of the host and novel defining properties of these molecules. The mapping of new resolution circuits has opened the possibility for understanding mechanisms that lead from acute to chronic inflammation, or to the resolution thereof, as well as to potential, resolution-based immunopharmacological therapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EPA and DHA are precursors to bioactive lipid metabolites, including specialized proresolving mediators and cytochrome P450-generated monoepoxides, that could contribute to lower CHD risk.
“Both EPA and DHA are also precursors to bioactive lipid metabolites, including specialized proresolving mediators36 and cytochrome P450–generated monoepoxides,37 that could contribute to lower CHD risk.”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [36]
Pro-resolving mediators block inflammatory cell influx, promote egress of inflammatory cells, modulate pro-inflammatory T cell responses, and promote clearance of pathogens and dead cells, limiting tissue damage and enabling repair.
“By activating cell-surface receptors, pro-resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, modulate pro-inflammatory T cell responses and promote clearance of both pathogens and dead cells (efferocytosis), with all these functions serving to limit tissue damage and to enable the repair of injured tissue29,30.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-3-460_4 · Cited by 4,593 · see citing works
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817 · see citing works
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works
Self-citationLeukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,858 · see citing works
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Self-citationLeukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233 · see citing works
Self-citation(1999) · PubMed · Cited by 2,062 · see citing works
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
Simopoulos, A. P. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719248 · Cited by 2,014 · see citing works
Robbins pathologic basis of disease
Cotran, R. S., Kumar, V., & Collins, T. (1989) · Medical Entomology and Zoology · Cited by 1,944 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
Self-citationLipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works
Self-citationInducible cyclooxygenase may have anti-inflammatory properties
Gilroy, D. W., Colville‐Nash, P., Willis, D., Chivers, J. E., Paul‐Clark, M. J., & Willoughby, D. A. (1999) · Nature Medicine · doi:10.1038/9550 · Cited by 1,243 · see citing works
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works
Self-citationResolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works
Self-citationA NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET
Burr, G. O., & Burr, M. M. (1929) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78281-5 · Cited by 1,170 · see citing works
Distribution, interconversion, and dose response of n-3 fatty acids in humans.
Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162 · see citing works
Macrophage death and defective inflammation resolution in atherosclerosis
Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · cited 2× · see citing works
“It has now become evident that the resolution program of acute inflammation remains largely uncharted and is critically needed to understand the pathophysiology of inflammation-resolution as well as to direct new therapeutic approaches.(11,18,19) This review gives an overview and update on the systematic elucidation o…”
BackgroundSelf-citationHong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Self-citationSerhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Self-citationThe Inflammatory Response to Cell Death
Rock, K. L., & Kono, H. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 945 · see citing works
Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works
Self-citationMechanisms of action of docosahexaenoic acid in the nervous system
Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919 · see citing works
Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions
Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081880 · Cited by 908 · see citing works
Self-citationLukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works
Self-citationInflammatory Resolution: new opportunities for drug discovery
Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772 · see citing works
Ye, R. D., Boulay, F., Wang, J. M., Dahlgren, C., Gerard, C. J., Parmentier, M., Serhan, C. N., & Murphy, P. M. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001578 · Cited by 767 · see citing works
Self-citationMukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · see citing works
Self-citationResolvin D1 binds human phagocytes with evidence for proresolving receptors
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works
Self-citationPolyunsaturated fatty acids and inflammatory processes: New twists in an old tale
Calder, P. C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.01.008 · Cited by 721 · see citing works
Clària, J., & Serhan, C. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9475 · Cited by 703 · see citing works
Self-citation心筋梗塞後のn-3多価不飽和脂肪酸とビタミンEの食事補給:GISSI-Prevenzione試験の結果
Marchioli, R., Valagussa, F., Franzosi, M. G., Geraci, E., Mininni, N., Nicolosi, G. L., Santini, M., Tavazzi, L., & Vecchio, C. (1999) · The Lancet · Cited by 702 · see citing works
Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins
Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S., & Serhan, C. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4345 · Cited by 699 · see citing works
Self-citationResolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695 · see citing works
Self-citationConnor, K. M., SanGiovanni, J. P., Löfqvist, C., Aderman, C. M., Chen, J., Higuchi, A., Hong, S., Pravda, E. A., Majchrzak, S. F., Carper, D. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1591 · Cited by 687 · see citing works
Self-citationGodson, C., Mitchell, S., Harvey, K., Petasis, N. A., Hogg, N., & Brady, H. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1663 · Cited by 638 · see citing works
Arita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works
Self-citationThe Pathophysiology of Aortic Cross-clamping and Unclamping
Gelman, S. (1995) · Anesthesiology · doi:10.1097/00000542-199504000-00027 · Cited by 608 · see citing works
Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., Blumberg, R. S., & Serhan, C. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409271102 · Cited by 590 · see citing works
Self-citationShimizu, T. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145616 · Cited by 577 · see citing works
González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 556 · see citing works
Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics
Ulrich, C. M., Bigler, J., & Potter, J. D. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1801 · Cited by 550 · see citing works
Resolvin D1 and Its Aspirin-triggered 17R Epimer
Sun, Y., Oh, S. F., Uddin, J., Yang, R., Gotlinger, K. H., Campbell, E. L., Colgan, S. P., Petasis, N. A., & Serhan, C. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609212200 · Cited by 541 · see citing works
Self-citationThe lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans
Tobin, D. M., Vary, J. C., Ray, J. P., Walsh, G. S., Dunstan, S. J., Bang, N. D., Hagge, D. A., Khadge, S., King, M., Hawn, T. R., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.013 · Cited by 529 · see citing works
Robbins Pathologic Basis of Disease
Chejfec, G. (1999) · Archives of Pathology & Laboratory Medicine · doi:10.5858/1999-123-859a-rpbod · Cited by 517 · see citing works
Rossi, A. G., Sawatzky, D. A., Walker, A., Ward, C., Sheldrake, T. A., Riley, N. A., Caldicott, A., Martínez‐Losa, M., Walker, T. R., Duffin, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1468 · Cited by 506 · see citing works
Hao, S., & Baltimore, D. (2009) · Nature Immunology · doi:10.1038/ni.1699 · Cited by 480 · see citing works
Structural basis for the activation of PPARγ by oxidized fatty acids
Itoh, T., Fairall, L., Amin, K., Inaba, Y., Szántó, A., Bálint, B. L., Nagy, L., Yamamoto, K., & Schwabe, J. W. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1474 · Cited by 465 · see citing works
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Chiang, N., Serhan, C. N., Dahlén, S., Drazen, J. M., Hay, D. W. P., Rovati, G. E., Shimizu, T., Yokomizo, T., & Brink, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.4 · Cited by 464 · see citing works
Self-citationSerhan, C. N. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.05.002 · Cited by 459 · see citing works
Self-citationSerhan, C. N., Gotlinger, K. H., Hong, S., Lu, Y., Siegelman, J. N., Baer, T. E., Yang, R., Colgan, S. P., & Petasis, N. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1848 · Cited by 457 · see citing works
Self-citationIdentification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
Fiore, S., Maddox, J. F., Perez, H. D., & Serhan, C. N. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.253 · Cited by 438 · see citing works
Self-citationRvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
Hastürk, H., Kantarcı, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Dyke, T. E. V. (2005) · The FASEB Journal · doi:10.1096/fj.05-4724fje · Cited by 437 · see citing works
Self-citationTakano, T., Fiore, S., Maddox, J. F., Brady, H. R., Petasis, N. A., & Serhan, C. N. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1693 · Cited by 433 · see citing works
Self-citationEvasion of innate immunity by parasitic protozoa
Sacks, D. L., & Sher, A. (2002) · Nature Immunology · doi:10.1038/ni1102-1041 · Cited by 432 · see citing works
Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus
Serhan, C. N., & Chiang, N. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707489 · Cited by 428 · see citing works
Self-citationHaworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008) · Nature Immunology · doi:10.1038/ni.1627 · Cited by 425 · see citing works
Self-citationMerched, A. J., Ko, K., Gotlinger, K. H., Serhan, C. N., & Chan, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-112201 · Cited by 414 · see citing works
Self-citationSerhan, C. N., Jain, A., Marleau, S., Clish, C. B., Kantarcı, A., Behbehani, B., Colgan, S. P., Stahl, G. L., Merched, A. J., Petasis, N. A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6856 · Cited by 405 · see citing works
Self-citationKataru, R. P., Jung, K., Jang, C., Yang, H., Schwendener, R. A., Baik, J. E., Han, S. H., Alitalo, K. K., & Koh, G. Y. (2009) · Blood · doi:10.1182/blood-2008-09-176776 · Cited by 403 · see citing works
Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
Hudert, C. A., Weylandt, K. H., Lü, Y., Wang, J., Hong, S., Dignass, A. U., Serhan, C. N., & Kang, J. X. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601280103 · Cited by 379 · see citing works
Self-citationChronic inflammation: a failure of resolution?
Lawrence, T., & Gilroy, D. W. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2006.00507.x · Cited by 373 · see citing works
Synthetic chemerin-derived peptides suppress inflammation through ChemR23
Cash, J. L., Hart, R., Russ, A., Dixon, J. P. C., Colledge, W. H., Doran, J., Hendrick, A. G., Carlton, M. B. L., & Greaves, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071601 · Cited by 372 · see citing works
Ariel, A., Fredman, G., Sun, Y., Kantarcı, A., Dyke, T. E. V., Luster, A. D., & Serhan, C. N. (2006) · Nature Immunology · doi:10.1038/ni1392 · Cited by 363 · see citing works
Self-citationProtectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness
Levy, B. D., Kohli, P., Gotlinger, K. H., Haworth, O., Hong, S., Kazani, S. D., Israel, E., Haley, K. J., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.496 · Cited by 357 · see citing works
Self-citationChen, M., Divangahi, M., Gan, H., Shin, D. S., Hong, S., Lee, D. M., Serhan, C. N., Behar, S. M., & Remold, H. G. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080767 · Cited by 352 · see citing works
Self-citationMulti-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4
Levy, B. D., Sanctis, G. T. D., Devchand, P. R., Kim, E., Ackerman, K. G., Schmidt, B. A. R., Szczeklik, W., Drazen, J. M., & Serhan, C. N. (2002) · Nature Medicine · doi:10.1038/nm748 · Cited by 350 · see citing works
Self-citationCCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
Aliberti, J., Sousa, C. R. E., Schito, M. L., Hieny, S. E., Wells, T. N. C., Hu, B., & Sher, A. (2000) · Nature Immunology · doi:10.1038/76957 · Cited by 349 · see citing works
Mesenchymal stem cells: the fibroblasts' new clothes?
Haniffa, M. A., Collin, M. P., Buckley, C. D., & Dazzi, F. (2008) · Haematologica · doi:10.3324/haematol.13699 · Cited by 346 · see citing works
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., et al. (2004) · Nature Immunology · doi:10.1038/ni1056 · Cited by 344 · see citing works
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
Byström, J., Evans, I. M., Newson, J., Stables, M. J., Toor, I. S., van Rooijen, N., Crawford, M., Colville‐Nash, P., Farrow, S. N., & Gilroy, D. W. (2008) · Blood · doi:10.1182/blood-2007-12-129767 · Cited by 335 · see citing works
Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury
Duffield, J. S., Hong, S., Vaidya, V. S., Lu, Y., Fredman, G., Serhan, C. N., & Bonventre, J. V. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5902 · Cited by 335 · see citing works
Self-citationEffects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
Morris, T., Stables, M. J., Hobbs, A. J., de Souza, P., Colville‐Nash, P., Warner, T. D., Newson, J., Bellingan, G. J., & Gilroy, D. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900477 · Cited by 322 · see citing works
Gronert, K., Maheshwari, N., Khan, N. A., Hassan, I., Dunn, M. W., & Schwartzman, M. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410638200 · Cited by 308 · see citing works
Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 306 · see citing works
Freire-de-Lima, C. G., Xiao, Y. Q., Gardai, S. J., Bratton, D. L., Schiemann, W. P., & Henson, P. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605146200 · Cited by 301 · see citing works
Dufton, N., Hannon, R., Brancaleone, V., Dalli, J., Patel, H., Gray, M., D’Acquisto, F., Buckingham, J. C., Perretti, M., & Flower, R. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903526 · Cited by 298 · see citing works
Canny, G., Levy, O., Furuta, G. T., Narravula-Alipati, S., Sisson, R. B., Serhan, C. N., & Colgan, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052533799 · Cited by 295 · see citing works
Self-citationMaddox, J. F., & Serhan, C. N. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.137 · Cited by 295 · see citing works
Self-citationResolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis
Ohira, T., Arita, M., Omori, K., Recchiuti, A., Van Dyke, T. E., & Serhan, C. N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044131 · Cited by 278 · see citing works
Self-citationRidker, P. M. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03404.x · Cited by 269 · see citing works
Chiang, N., Bermudez, E. A., Ridker, P. M., Hurwitz, S., & Serhan, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405445101 · Cited by 266 · see citing works
Self-citationBáfica, A. L. B., Scanga, C. A., Serhan, C. N., Machado, F. S., White, S., Sher, A., & Aliberti, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23949 · Cited by 251 · see citing works
Self-citationAriel, A., Li, P., Wang, W., Tang, W.-X., Fredman, G., Hong, S., Gotlinger, K. H., & Serhan, C. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509796200 · Cited by 247 · see citing works
Self-citationTjonahen, E., Oh, S. F., Siegelman, J. N., Elangovan, S., Percarpio, K. B., Hong, S., Arita, M., & Serhan, C. N. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.011 · Cited by 241 · see citing works
Self-citationRapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution
Kasuga, K., Yang, R., Porter, T. F., Agrawal, N., Petasis, N. A., Irimia, D., Toner, M., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8677 · Cited by 240 · see citing works
Self-citationTakano, T., Clish, C. B., Gronert, K., Petasis, N. A., & Serhan, C. N. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1578 · Cited by 230 · see citing works
Self-citationMichlewska, S., Dransfield, I., Megson, I. L., & Rossi, A. G. (2008) · The FASEB Journal · doi:10.1096/fj.08-121228 · Cited by 228 · see citing works
Dona, M., Fredman, G., Schwab, J. M., Chiang, N., Arita, M., Goodarzi, A., Cheng, G., von Andrian, U. H., & Serhan, C. N. (2008) · Blood · doi:10.1182/blood-2007-11-122598 · Cited by 228 · see citing works
Self-citationhPPARgamma Ligand binding domain in complex with 4-HDHA
Itoh, T., Fairall, L., & Schwabe, J. W. R. (2008) · Worldwide Protein Data Bank · doi:10.2210/pdb2vv1/pdb · Cited by 223 · see citing works
Effect of fish oil on arrhythmias and mortality: systematic review.
Leon, H., Shibata, M. C., Sivakumaran, S., Dorgan, M., Chatterley, T., & Tsuyuki, R. T. (2008) · BMJ · doi:10.1136/bmj.a2931 · Cited by 223 · see citing works
Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works
Whelan, J. (2008) · Journal of Nutrition · doi:10.3945/jn.108.094268 · Cited by 206 · see citing works
Campbell, E. L., Louis, N. A., Tomassetti, S. E., Canny, G. O., Arita, M., Serhan, C. N., & Colgan, S. P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8473com · Cited by 205 · see citing works
Self-citationThe opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase
Vance, R. E., Hong, S., Gronert, K., Serhan, C. N., & Mekalanos, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307308101 · Cited by 192 · see citing works
Self-citationWilloughby, D. A., Moore, A., Colville‐Nash, P., & Gilroy, D. W. (2000) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(00)00064-3 · Cited by 190 · see citing works
Devchand, P. R., Arita, M., Hong, S., Bannenberg, G. L., Moussignac, R., Gronert, K., & Serhan, C. N. (2003) · The FASEB Journal · doi:10.1096/fj.02-0770com · Cited by 176 · see citing works
Self-citationSerhan, C. N. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0695-8 · Cited by 175 · see citing works
Self-citationA novel role for phospholipase A 2 isoforms in the checkpoint control of acute inflammation
Gilroy, D. W., Newson, J., Sawmynaden, P., Willoughby, D. A., & Croxtall, J. D. (2004) · The FASEB Journal · doi:10.1096/fj.03-0837com · Cited by 175 · see citing works
Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing
Svensson, C. I., Zattoni, M., & Serhan, C. N. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061826 · Cited by 175 · see citing works
Self-citationBirnbaum, Y., Ye, Y., Lin, Y., Freeberg, S. Y., Nishi, S. P. E., Martinez, J. D., Huang, M.-H., Uretsky, B. F., & Perez-Polo, J. R. (2006) · Circulation · doi:10.1161/circulationaha.106.629907 · Cited by 173 · see citing works
Ishida, T., Yoshida, M., Arita, M., Nishitani, Y., Nishiumi, S., Masuda, A., Mizuno, S., Takagawa, T., Morita, Y., Kutsumi, H., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21029 · Cited by 172 · see citing works
Self-citationResolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma
Aoki, H., Hisada, T., Ishizuka, T., Utsugi, M., Kawata, T., Shimizu, Y., Okajima, F., Dobashi, K., & Mori, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.012 · Cited by 172 · see citing works
Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions
Arita, M., Oh, S. F., Chonan, T., Hong, S., Elangovan, S., Sun, Y., Uddin, J., Petasis, N. A., & Serhan, C. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603766200 · Cited by 168 · see citing works
Self-citationLi, S., Sun, Y., Liang, C., Thorp, E. B., Han, S., Jehle, A. W., Saraswathi, V., Pridgen, B. C., Kanter, J. E., Li, R., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199570 · Cited by 168 · see citing works
12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis
Krönke, G., Katzenbeisser, J., Uderhardt, S., Zaiss, M. M., Scholtysek, C., Schabbauer, G., Zarbock, A., Koenders, M. I., Axmann, R., Zwerina, J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900327 · Cited by 163 · see citing works
Lipoxins: endogenous regulators of inflammation
McMahon, B. A., & Godson, C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00224.2003 · Cited by 148 · see citing works
Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators
Jin, Y., Arita, M., Zhang, Q., Saban, D. R., Chauhan, S. K., Chiang, N., Serhan, C. N., & Dana, R. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2462 · Cited by 144 · see citing works
Self-citationHeasman, S. J., Giles, K., Ward, C., Rossi, A., Haslett, C., & Dransfield, I. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780029 · Cited by 141 · see citing works
A critique of paradoxes in current advice on dietary lipids
Lands, B. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.001 · Cited by 137 · see citing works
Arita, M., Clish, C. B., & Serhan, C. N. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.181 · Cited by 128 · see citing works
Self-citationMetchnikoff and the origins of immunology: from metaphor to theory
(1992) · Choice Reviews Online · doi:10.5860/choice.29-5110 · Cited by 116 · see citing works
Hassan, I., & Gronert, K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802064 · Cited by 114 · see citing works
Taggart, C. C., Greene, C. M., Carroll, T. P., O'Neill, S. J., & McElvaney, N. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-881pp · Cited by 113 · see citing works
Anesthetics Impact the Resolution of Inflammation
Chiang, N., Schwab, J. M., Fredman, G., Kasuga, K., Gelman, S., & Serhan, C. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001879 · Cited by 109 · see citing works
Self-citationProstaglandins, bioassay and inflammation
Flower, R. J. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706506 · Cited by 107 · see citing works
Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution
Hong, S., Porter, T. F., Lu, Y., Oh, S. F., Pillai, P. S., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3512 · Cited by 107 · see citing works
Self-citationDocosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina
Bazan, N. G., Birkle, D. L., & Reddy, T. S. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90601-6 · Cited by 107 · see citing works
Blaho, V. A., Buczynski, M. W., Brown, C. R., & Dennis, E. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003822 · Cited by 106 · see citing works
Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1
Haas-Stapleton, E. J., Lü, Y., Hong, S., Arita, M., Favoreto, S., Nigam, S., Serhan, C. N., & Agabian, N. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001316 · Cited by 103 · see citing works
Self-citationPatil, V. S., & Magar, N. G. (1960) · Biochemical Journal · doi:10.1042/bj0740427 · Cited by 102 · see citing works
Marcheselli, V. L., Mukherjee, P. K., Arita, M., Hong, S., Antony, R., Sheets, K. G., Winkler, J. W., Petasis, N. A., Serhan, C. N., & Bazan, N. G. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.10.010 · Cited by 101 · see citing works
Self-citationWinyard, P. G., & Willoughby, D. A. (2003) · Humana Press eBooks · doi:10.1385/1592593747 · Cited by 101 · see citing works
Navarro-Xavier, R., Newson, J., Silveira, V. L. F., Farrow, S. N., Gilroy, D. W., & Byström, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902866 · Cited by 99 · see citing works
Exogenous Pathogen and Plant 15-Lipoxygenase Initiate Endogenous Lipoxin A4 Biosynthesis
Bannenberg, G. L., Aliberti, J., Hong, S., Sher, A., & Serhan, C. N. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031325 · Cited by 97 · see citing works
Self-citationPrimary inherited defects in neutrophil function: etiology and treatment.
Malech, H. L., & Nauseef, W. M. (1997) · PubMed · Cited by 94 · see citing works
Martins, V., Valença, S. S., Farias‐Filho, F. A., Molinaro, R., Simões, R. L., Ferreira, T. P. T., Silva, P., Hogaboam, C. M., Kunkel, S. L., Fierro, I. M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802259 · Cited by 81 · see citing works
Total Synthesis and Bioactivity of Resolvin E2
Ogawa, S., Urabe, D., Yokokura, Y., Arai, H., Arita, M., & Inoue, M. (2009) · Organic Letters · doi:10.1021/ol901350g · Cited by 78 · see citing works
Tian, H., Lu, Y., Sherwood, A. M., Hongqian, D., & Hong, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3146 · Cited by 76 · see citing works
Aspirin Has A Gender-Dependent Impact on Antiinflammatory 15-Epi-Lipoxin A 4 Formation
Chiang, N., Hurwitz, S., Ridker, P. M., & Serhan, C. N. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000196729.98651.bf · Cited by 70 · see citing works
Self-citationDangi, B., Obeng, M., Nauroth, J. M., Teymourlouei, M., Needham, M., Raman, K. P., & Arterburn, L. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809014200 · Cited by 68 · see citing works
Huang, B. X., Dass, C., & Kim, H. (2005) · Biochemical Journal · doi:10.1042/bj20041624 · Cited by 65 · see citing works
A magic bullet for mucosal protection…and aspirin is the trigger!
Wallace, J. L., & Fiorucci, S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00166-4 · Cited by 64 · see citing works
REGULATION OF LUNG INFLAMMATION IN THE MODEL OF IGG IMMUNE-COMPLEX INJURY
Gao, H., Neff, T. A., & Ward, P. A. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100155 · Cited by 63 · see citing works
Wu, S., Liao, P., Yin, P., Zhang, Y., & Dong, L. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080671 · Cited by 62 · see citing works
Therapeutic Roles Of Selective Cox-2 Inhibitors
Vane, J. R., & Botting, R. M. (2001) · Medical Entomology and Zoology · Cited by 58 · see citing works
Vassiliou, E. K., Kesler, O. M., Tadros, J. H., & Ganea, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4534 · Cited by 56 · see citing works
Ye, Y., Lin, Y., Perez-Polo, J. R., Uretsky, B. F., Ye, Z., Tieu, B. C., & Birnbaum, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3515 · Cited by 55 · see citing works
Therapeutic roles of selective COX-2 inhibitors
Graham, D. Y. (2002) · Gastroenterology · doi:10.1016/s0016-5085(02)80092-0 · Cited by 54 · see citing works
Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery
He, J., & Bazán, H. E. P. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.004 · Cited by 44 · see citing works
Aspirin and steroids: new mechanistic findings and avenues for drug discovery
Gilroy, D. W., & Perretti, M. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.02.006 · Cited by 42 · see citing works
Menezes‐de‐Lima, O., Kassuya, C. A. L., Nascimento, A. F. Z., Henriques, M. D. G., & Calixto, J. Β. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.016 · Cited by 41 · see citing works
Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse.
Sheets, K. G., Zhou, Y., Ertel, M. K., Knott, E. J., Regan, C. E., Elison, J. R., Gordon, W. C., Gjorstrup, P., & Bazan, N. G. (2010) · PubMed Central · Cited by 40 · see citing works
Lipid mediator informatics-lipidomics: Novel pathways in mapping resolution
Serhan, C. N., Hong, S., & Lü, Y. (2006) · The AAPS Journal · doi:10.1007/bf02854899 · Cited by 39 · see citing works
Self-citationKupczyk, M., Antczak, A. J., Kuprys-Lipinska, I. R., & Kuna, P. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02047.x · Cited by 32 · see citing works
Endogenous Chemical Mediators in Anti-Inflammation and Pro-Resolution
Serhan, C. N. (2002) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1568014023355881 · Cited by 31 · see citing works
Self-citationResolvins: Current understanding and future potential in the control of inflammation.
Bannenberg, G. L. (2009) · PubMed · Cited by 28 · see citing works
TB: Screening for Responses to a Vile Visitor
Behr, M. A., Schurr, E., & Gros, P. (2010) · Cell · doi:10.1016/j.cell.2010.02.030 · Cited by 28 · see citing works
Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch–Schönlein purpura
Wu, S., Liao, P., Yin, P., Zhang, Y.-M., & Dong, L. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.01.008 · Cited by 27 · see citing works
Cloning Genes Encoding Receptors Related to Chemoattractant Receptors
Marchese, A., Nguyen, T., Malik, P., Xu, S., Cheng, R., Xie, Z., Heng, H. H., George, S. R., Kolakowski, L. F., & O’Dowd, B. F. (1998) · Genomics · doi:10.1006/geno.1998.5297 · Cited by 25 · see citing works
Serhan, C. N. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.07.001 · Cited by 23 · see citing works
Self-citationPhagocyte-pathogen interactions : macrophages and the host response to infection
Russell, D. G., & Gordon, S. (2009) · Cited by 21 · see citing works
The Resolution of Inflammation
Rossi, A. G., & Sawatsky, D. A. (2008) · Inflammopharmacology · doi:10.1007/s10787-008-1625-5 · Cited by 16 · see citing works
Inflammation and infection: historic highlights.
Majno, G. (1982) · PubMed · Cited by 15 · see citing works
Henson, P. M. (1991) · CHEST Journal · doi:10.1378/chest.99.3_supplement.2s · Cited by 11 · see citing works
Andersson, P., Serhan, C. N., Petasis, N. A., & Palmblad, J. E. W. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01469.x · Cited by 11 · see citing works
Self-citationFilep, J. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00235.x · Cited by 10 · see citing works
Bellingan, G. J. (2006) · Springer eBooks · doi:10.1007/3-540-30328-6_10 · Cited by 7 · see citing works
Removing Proinflammatory Signals
Gough, N. R. (2006) · Science s STKE · doi:10.1126/stke.3592006tw368 · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 166 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac R-L: Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals. J Exp Med 2002, 196:1025-1037
- Serhan CN: guest ed.: Special Issue on Lipoxins and Aspirin-Trig- gered Lipoxins. Prostaglandins Leukot Essent Fatty Acids 2005, 73(3-4):139 -321
- Cassatella MA: The Neutrophil. Edited by Cassatella MA. Basel, Karger 2003
- Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, 1588 Serhan AJP October 2010, Vol. 177, No.
- Jin Y, Arita M, Zhang Q, Saban DR, Chauhan SK, Chiang N, Serhan CN, Dana MR: Novel anti-inflammatory and pro-resolving lipid me- diators block inflammatory angiogenesis. Invest Ophthalmol Vis Sci 2009, 50:4743-4752
- Wu S-H, Liao P-Y, Yin P-L, Zhang Y-M, Dong L: Elevated expres- sions of 15-lipoxygenase and lipoxin A 4 in children with acute post- streptococcal glomerulonephritis. Am J Pathol 2009, 174:115-122
- Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA: Inducible cycloxygenase may have anti-inflamma- tory properties. Nat Med 1999, 5:698 -701 155.
Cited by
Sorted by citations
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works
Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771 · see citing works
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works
Regulation of the Inflammatory Response in Cardiac Repair
Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,196 · see citing works
The Neutrophil's Role During Health and Disease.
Liew, P., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,032 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
Self-citationProresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 811 · see citing works
Self-citationMonocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works
Pathophysiology of Myocardial Infarction
Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150006 · Cited by 717 · see citing works
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
Serhan, C. N., Dalli, J., Karamnov, S., Choi, A. J. S., Park, C., Xu, Z., Ji, R., Zhu, M., & Petasis, N. A. (2012) · The FASEB Journal · doi:10.1096/fj.11-201442 · Cited by 596 · see citing works
Self-citationMonocyte and Macrophage Dynamics During Atherogenesis
Ley, K. F., Miller, Y. I., & Hedrick, C. C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221127 · Cited by 553 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Self-citationFibroblasts in myocardial infarction: A role in inflammation and repair
Shinde, A. V., & Frangogiannis, N. G. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.015 · Cited by 516 · see citing works
Inflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress
Shvedova, A. A., Pietroiusti, A., Fadeel, B., & Kagan, V. E. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.03.023 · Cited by 516 · see citing works
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works
Self-citationCellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2013) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.10.004 · Cited by 491 · see citing works
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Cellular Metabolism and Macrophage Functional Polarization
Zhu, L.-N., Zhao, Q.-J., Yang, T., Ding, W.-J., & Zhao, Y. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2014.969421 · Cited by 412 · see citing works
More friend than foe: the emerging role of neutrophils in tissue repair
Peiseler, M., & Kubes, P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124616 · Cited by 423 · see citing works
Del Gobbo, L. C., Imamura, F., Aslibekyan, S., Marklund, M., Virtanen, J. K., Wennberg, M., Yakoob, M. Y., Chiuve, S. E., dela Cruz, L., Frazier-Wood, A. C., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.2925 · Cited by 404 · see citing works
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
Yates, C. M., Calder, P. C., & Rainger, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.010 · Cited by 396 · see citing works
New anti-inflammatory targets for chronic obstructive pulmonary disease
Barnes, P. J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4025 · Cited by 393 · see citing works
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353 · see citing works
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342 · see citing works
Regulation of inflammation in cancer by eicosanoids
Greene, E. R., Huang, S., Serhan, C. N., & Panigrahy, D. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.08.004 · Cited by 303 · see citing works
Self-citationResolution of inflammation is altered in Alzheimer's disease
Wang, X., Zhu, M., Hjorth, E., Cortés‐Toro, V., Eyjolfsdottir, H., Graff, C., Nennesmo, I., Palmblad, J., Eriksdotter, M., Sambamurti, K., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.024 · Cited by 301 · see citing works
Self-citationThe biology of cancer-related fatigue: a review of the literature
Saligan, L. N., Olson, K. L., Filler, K., Larkin, D., Cramp, F. L., Yennurajalingam, S., Escalante, C. P., del Giglio, A., Kober, K. M., Kamath, J., et al. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2763-0 · Cited by 298 · see citing works
Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Fredman, G., & Serhan, C. N. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.01.028 · Cited by 283 · see citing works
Self-citationCancer Inflammation and CytokinesPreprint
Galdiero, M. R., Marone, G., & Mantovani, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028662 · Cited by 267 · see citing works
The role of non-resolving inflammation in atherosclerosis
Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97950 · Cited by 266 · see citing works
Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.001 · Cited by 266 · see citing works
Self-citationPetri, B., & Sanz, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2776-8 · Cited by 247 · see citing works
Fagundes, C. T., Amaral, F. A., Vieira, A. T., Soares, A. C., Pinho, V., Nicoli, J. R., Vieira, L. Q., Teixeira, M. M., & Souza, D. G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101682 · Cited by 244 · see citing works
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works
Neuhofer, A., Zeyda, M., Mascher, D. G., Itariu, B. K., Murano, I., Leitner, L., Hochbrugger, E., Fraisl, P., Cinti, S., Serhan, C. N., et al. (2013) · Diabetes · doi:10.2337/db12-0828 · Cited by 232 · see citing works
Self-citationHjorth, E., Zhu, M., Toro, V. C., Vedin, I., Palmblad, J. E. W., Cederholm, T., Freund‐Levi, Y., Irving, G. F., Wahlund, L., Basun, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130131 · Cited by 229 · see citing works
Loynes, C. A., Lee, J. A., Robertson, A. L., Steel, M. J., Ellett, F. E., Feng, Y., Levy, B. D., Whyte, M. K. B., & Renshaw, S. A. (2018) · Science Advances · doi:10.1126/sciadv.aar8320 · Cited by 221 · see citing works
Marventano, S., Kolacz, P., Castellano, S., Galvano, F., Buscemi, S., Mistretta, A., & Grosso, G. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1077790 · Cited by 220 · see citing works
Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles
Kamaly, N., Fredman, G., Subramanian, M., Gadde, S., Pešić, A., Cheung, L., Fayad, Z. A., Langer, R., Tabas, I. A., & Farokhzad, O. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303377110 · Cited by 215 · see citing works
Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage
Hastürk, H., Kantarcı, A., & Dyke, T. E. V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00118 · Cited by 212 · see citing works
Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212 · see citing works
Self-citationGiera, M. A., Ioan‐Facsinay, A., Toes, R. E. M., Gao, F., Dalli, J., Deelder, A. M., Serhan, C. N., & Mayboroda, O. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.011 · Cited by 210 · see citing works
Self-citationFaouder, P. L., Baillif, V., Spreadbury, I., Motta, J., Rousset, P., Chêne, G., Guigné, C., Tercé, F., Vanner, S. J., Vergnolle, N., et al. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.06.014 · Cited by 207 · see citing works
Targeting inflammatory pathways in myocardial infarction
Christia, P., & Frangogiannis, N. G. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12118 · Cited by 207 · see citing works
Kain, V., Prabhu, S. D., & Halade, G. V. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0444-7 · Cited by 202 · see citing works
Galvão, I., Sugimoto, M. A., Vago, J. P., Machado, M. G., & Sousa, L. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-77658-3_1 · Cited by 202 · see citing works
Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked
Wisastra, R., & Dekker, F. J. (2014) · Cancers · doi:10.3390/cancers6031500 · Cited by 202 · see citing works
The resolution of inflammation: the devil in the flask and in the details
Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-0502ufm · Cited by 195 · see citing works
Self-citationFredman, G., Özcan, L., Spolitu, S., Hellmann, J. L., Spite, M. R., Backs, J., & Tabas, I. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410851111 · Cited by 193 · see citing works
Gu, J., Luo, L., Wang, Q., Yan, S.-F., Lin, J., Li, D., Cao, B., Mei, H., Ying, B., Bin, L., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0031-x · Cited by 189 · see citing works
Schoultz, I., & Keita, Å. V. (2019) · Cells · doi:10.3390/cells8020193 · Cited by 187 · see citing works
Ariel, A., & Serhan, C. N. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00004 · Cited by 184 · see citing works
Self-citationInflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
cAMP and Epac in the regulation of tissue fibrosis
Insel, P. A., Murray, F., Yokoyama, U., Romano, S., Yun, H., Brown, L., Snead, A., Lu, D., & Aroonsakool, N. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01847.x · Cited by 175 · see citing works
Gautier, E. L., Chow, A. T., Spanbroek, R., Marcelin, G., Greter, M., Jakubzick, C., Bogunovic, M., Leboeuf, M., van Rooijen, N., Habenicht, A. J. R., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200495 · Cited by 167 · see citing works
Markworth, J. F., Vella, L. D., Lingard, B. S., Tull, D., Rupasinghe, T., Sinclair, A. J., Maddipati, K. R., & Cameron‐Smith, D. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00128.2013 · Cited by 163 · see citing works
Poo, Y. S., Nakaya, H. I., Gardner, J., Larcher, T., Schroder, W. A., Le, T. T., Major, L. D., & Suhrbier, A. (2014) · Journal of Virology · doi:10.1128/jvi.03364-13 · Cited by 149 · see citing works
Liao, Z., Dong, J., Wu, W., Yang, T., Wang, T., Guo, L., Chen, L., Xu, D., & Wen, F. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-110 · Cited by 149 · see citing works
Aspirin‐triggered resolvin D1 prevents surgery‐induced cognitive decline
Terrando, N., Gómez‐Galán, M., Yang, T., Carlström, M., Gustavsson, D., Harding, R. E., Lindskog, M., & Eriksson, L. I. (2013) · The FASEB Journal · doi:10.1096/fj.13-230276 · Cited by 147 · see citing works
Pro-Resolving Mediators in Regulating and Conferring Macrophage Function
Dalli, J., & Serhan, C. N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01400 · Cited by 147 · see citing works
Self-citationMacrophage and microglial plasticity in the injured spinal cord
David, S., Greenhalgh, A. D., & Kroner, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.064 · Cited by 141 · see citing works
Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?
Niki, E. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.09.025 · Cited by 138 · see citing works
Inflammatory triggers of acute rejection of organ allografts
Mori, D. N., Kreisel, D., Fullerton, J. N., Gilroy, D. W., & Goldstein, D. R. (2014) · Immunological Reviews · doi:10.1111/imr.12146 · Cited by 137 · see citing works
McGrath, E. E., Marriott, H. M., Lawrie, A., Francis, S., Sabroe, I., Renshaw, S. A., Dockrell, D. H., & Whyte, M. K. B. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211062 · Cited by 137 · see citing works
ω-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer
Wang, W., Zhu, J., Lyu, F., Panigrahy, D., Ferrara, K. W., Hammock, B. D., & Zhang, G. (2014) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2014.07.002 · Cited by 132 · see citing works
Diversity of lipid mediators in human adipose tissue depots
Clària, J., Nguyen, B. T., Madenci, A. L., Ozaki, C. K., & Serhan, C. N. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00351.2012 · Cited by 130 · see citing works
Self-citationBo, Y., Zhang, X., Wang, Y., You, J., Cui, H., Zhu, Y., Pang, W., Liu, W. Y., Jiang, Y., & Lü, Q. (2017) · Nutrients · doi:10.3390/nu9010054 · Cited by 133 · see citing works
Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients
Yang, J., Eiserich, J. P., Cross, C. E., Morrissey, B. M., & Hammock, B. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.001 · Cited by 128 · see citing works
Fredman, G., Li, Y., Dalli, J., Chiang, N., & Serhan, C. N. (2012) · Scientific Reports · doi:10.1038/srep00639 · Cited by 122 · see citing works
Self-citationMacrophage Proresolving Mediators—the When and Where
Dalli, J., & Serhan, C. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0001-2014 · Cited by 121 · see citing works
Self-citationLipoxin A 4 and benzo‐lipoxin A 4 attenuate experimental renal fibrosis
Börgeson, E., Docherty, N. G., Murphy, M., Rodgers, K., Ryan, A., O’Sullivan, T. P., Guiry, P. J., Goldschmeding, R., Higgins, D. F., & Godson, C. (2011) · The FASEB Journal · doi:10.1096/fj.11-185017 · Cited by 120 · see citing works
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis
Gobbetti, T., Coldewey, S. M., Chen, J., McArthur, S., Faouder, P. L., Cénac, N., Flower, R. J., Thiemermann, C., & Perretti, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410938111 · Cited by 119 · see citing works
Pathophysiology of Myocardial Infarction
Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00664.x · Cited by 117 · see citing works
β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels
Chen, C. T., & Bazinet, R. P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.007 · Cited by 110 · see citing works
Hussey, G. S., Molina, C. P., Cramer, M. C., Tyurina, Y. Y., Tyurin, V. A., Lee, Y. C., El-Mossier, S. O., Murdock, M. H., Timashev, P. S., Kagan, V. E., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4361 · Cited by 109 · see citing works
Rius, B., Titos, E., Morán‐Salvador, E., López‐Vicario, C., García‐Alonso, V., González‐Périz, A., Arroyo, V., & Clària, J. (2013) · The FASEB Journal · doi:10.1096/fj.13-235614 · Cited by 110 · see citing works
Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
McNamara, R. K., & Lotrich, F. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.98 · Cited by 109 · see citing works
Toledo, E., Wang, D. D., Ruiz‐Canela, M., Clish, C. B., Razquín, C., Zheng, Y., Guasch‐Ferré, M., Hruby, A., Corella, D., Gómez‐Gracia, E., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.151159 · Cited by 108 · see citing works
The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases
Pellegrini, M., Senni, C., Bernabei, F., Cicero, A. F. G., Vagge, A., Maestri, A., Scorcia, V., & Giannaccare, G. (2020) · Nutrients · doi:10.3390/nu12040952 · Cited by 107 · see citing works
Ostermann, A. I., Willenberg, I., & Schebb, N. H. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8377-4 · Cited by 104 · see citing works
Kutzner, L., Rund, K. M., Ostermann, A. I., Hartung, N. M., Galano, J., Balas, L., Durand, T., Balzer, M. S., David, S., & Schebb, N. H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00169 · Cited by 106 · see citing works
Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases
Abdolmaleki, F., Kovanen, P. T., Mardani, R., Hayat, S. M. G., Bo, S., & Sahebkar, A. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08754-9 · Cited by 104 · see citing works
Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming
Reátegui, E., Jalali, F., Khankhel, A. H., Wong, E. A., Cho, H., Lee, J., Serhan, C. N., Dalli, J., Elliott, H. L., & Irimia, D. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0094 · Cited by 97 · see citing works
Self-citationImpact of Resolvin E1 on Murine Neutrophil Phagocytosis in Type 2 Diabetes
Herrera, B. S., Hastürk, H., Kantarcı, A., Freire, M., Nguyen, O., Kansal, S., & Dyke, T. E. V. (2014) · Infection and Immunity · doi:10.1128/iai.02444-14 · Cited by 93 · see citing works
Dakin, S. G., Werling, D., Hibbert, A. P., Abayasekara, D. R. E., Young, N. J., Smith, R. K. W., & Dudhia, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032333 · Cited by 93 · see citing works
Schlager, S., Goeritzer, M., Jandl, K., Frei, R., Vujić, N., Kolb, D., Strohmaier, H. M., Dorow, J., Eichmann, T. O., Rosenberger, A., et al. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0515-206r · Cited by 92 · see citing works
2016 Russell Ross Memorial Lecture in Vascular Biology
Tabas, I. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308036 · Cited by 92 · see citing works
Liu, T., Xiang, A., Peng, T., Doran, A. C., Tracey, K. J., Barnes, B. J., Tabas, I. A., Son, M., & Diamond, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907490116 · Cited by 93 · see citing works
Hanging in the balance: endogenous anti‐inflammatory mechanisms in tissue repair and fibrosis
Ariel, A., & Zeituni-Timor, O. (2012) · The Journal of Pathology · doi:10.1002/path.4108 · Cited by 91 · see citing works
Lipid mediators in immune dysfunction after severe inflammation
Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.008 · Cited by 87 · see citing works
Nosaka, K., Miyoshi, T., Iwamoto, M., Kajiya, M., Okawa, K., Tsukuda, S., Yokohama, F., Sogo, M., Nishibe, T., Matsuo, N., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.105 · Cited by 88 · see citing works
Liuzzi, J. P., Guo, L., Yoo, C., & Stewart, T. S.-J. (2014) · BioMetals · doi:10.1007/s10534-014-9773-0 · Cited by 88 · see citing works
Mescher, A. L., Neff, A. W., & King, M. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080477 · Cited by 85 · see citing works
EPA- and DHA-derived resolvins' actions in inflammatory bowel disease
Schwanke, R. C., Marcon, R., Bento, A. F., & Calixto, J. Β. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.050 · Cited by 83 · see citing works
Interplay of NK cells and monocytes in vascular inflammation and myocardial infarction
Knorr, M., Münzel, T. F., & Wenzel, P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00295 · Cited by 85 · see citing works
Werner, K., de Gaudry, D. K., Taylor, L. A., Keck, T., Unger, C., Hopt, U. T., & Massing, U. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0495-5 · Cited by 83 · see citing works
Pathways mediating resolution of inflammation: when enough is too much
Fullerton, J. N., O'Brien, A. J., & Gilroy, D. W. (2013) · The Journal of Pathology · doi:10.1002/path.4232 · Cited by 81 · see citing works
- Authors
- Serhan, C. N.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- ORCID
- Serhan, Charles N.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 177
- Issue
- 4
- Pages
- 1576-1591
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC2947253
- OpenAlex
- W153263572
- Cited by
- 421
- References
- 166
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 17 · 2023: 18 · 2022: 15 · 2021: 27 · 2020: 27 · 2019: 28 · 2018: 26 · 2017: 31 · 2016: 23 · 2015: 26 · 2014: 55 · 2013: 45 · 2012: 38
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM038765, DK074448, DE019938)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- inflammation resolution, specialized pro-resolving mediators, lipoxins, resolvins, protectins, maresins, essential fatty acids, leukocyte migration, macrophage clearance, neutrophil infiltration, chronic inflammation, anti-inflammatory mediators, inflammatory exudate
- MeSH terms
- Animals, Humans, Inflammation, Lipids, Signal Transduction, Inflammation Mediators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review