Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia
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In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l−1 in non-pregnant females and < 130 g.l−1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, measuring hemoglobin concentration, total hemoglobin mass (optimized carbon monoxide rebreathing method) and thereby calculating plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r=0.687–0.871, P
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The dermis is comprised of connective tissue along with blood vessels (capillaries and arterioles) with blood volume ratios ranging from 0.2 to 7% and water volume concentration around 65%.
“The dermis is comprised of connective tissue along with blood vessels (capillaries and arterioles) with blood volume ratios ranging from 0.2 to 7% and water volume concentration around 65%55,56.”
From Synthetic photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to body mass index (BMI) (2021) · cites this paper as [56]
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Statistical power analyses using G∗Power 3.1: tests for correlation and regression analyses
Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009) · Behavior Research Methods · doi:10.3758/brm.41.4.1149 · Cited by 37,615 · see citing works
Discovering Statistics Using SPSS
Field, A. P., & Miles, J. N. V. (2000) · Medical Entomology and Zoology · Cited by 28,268 · see citing works
Stevens, G. A., Finucane, M. M., De‐Regil, L. M., Paciorek, C., Flaxman, S. R., Branca, F., Peña‐Rosas, J. P., Bhutta, Z. A., & Ezzati, M. (2013) · The Lancet Global Health · doi:10.1016/s2214-109x(13)70001-9 · Cited by 1,977 · see citing works
ON THE COMPARISON OF SEVERAL MEAN VALUES: AN ALTERNATIVE APPROACH
Welch, B. L. (1951) · Biometrika · doi:10.1093/biomet/38.3-4.330 · Cited by 1,531 · see citing works
Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study
Musallam, K. M., Tamim, H., Richards, T., Spahn, D. R., Rosendaal, F. R., Habbal, A., Khreiss, M. R., Dahdaleh, F. S., Khavandi, K., Sfeir, P. M., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61381-0 · Cited by 1,263 · see citing works
Self-citationPrevalence and outcomes of anemia in cancer: a systematic review of the literature
Knight, K., Wade, S., & Balducci, L. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.12.008 · Cited by 878 · see citing works
Ezekowitz, J. A., McAlister, F. A., & Armstrong, P. W. (2003) · Circulation · doi:10.1161/01.cir.0000052622.51963.fc · Cited by 866 · see citing works
Jaime, J., Salas, M., Ward, A., & Goss, G. D. (2001) · PubMed · Cited by 844 · see citing works
Silverberg, D. S., Wexler, D., Blum, M., Keren, G., Sheps, D. S., Leibovitch, E., Brosh, D., Laniado, S., Schwartz, D., Yachnin, T., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00613-6 · Cited by 725 · see citing works
Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., & Borenstein, J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01854-5 · Cited by 712 · see citing works
Hemodilution Is Common in Patients With Advanced Heart Failure
Androne, A. S., Katz, S. D., Lund, L. H., LaManca, J. J., Hudaihed, A., Hryniewicz, K. M., & MANCINI, D. M. (2003) · Circulation · doi:10.1161/01.cir.0000052623.16194.80 · Cited by 485 · see citing works
The prevalence of anemia in patients with chronic kidney disease
McClellan, W., Aronoff, S. L., Bolton, W. K., Hood, S. A., Lorber, D. L., Tang, K. L., Tse, T. F., Wasserman, B., & Leiserowitz, M. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904x2763 · Cited by 472 · see citing works
The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
Schmidt, W., & Prommer, N. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0050-3 · Cited by 408 · see citing works
Self-citationPrognostic Value of the Hematocrit in Patients With Severe COPD Receiving Long-term Oxygen Therapy
Chambellan, A., Chailleux, E., & Similowski, T. (2005) · CHEST Journal · doi:10.1378/chest.128.3.1201 · Cited by 241 · see citing works
Spectrum of anemia associated with chronic liver disease
González-Casas, R., Jones, E. A., & Moreno‐Otero, R. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.4653 · Cited by 235 · see citing works
Blood Volume and Hemoglobin Mass in Elite Athletes of Different Disciplines
Heinicke, K., Wolfarth, B., Winchenbach, P., Biermann, B., Schmid, A., Huber, G., Friedmann, B., & Schmidt, W. (2001) · International Journal of Sports Medicine · doi:10.1055/s-2001-17613 · Cited by 214 · see citing works
Self-citationPrevalence of Anemia in Inflammatory Bowel Diseases in European Countries
Filmann, N., Rey, J., Schneeweiss, S., Ardizzone, S., Bager, P., Bergamaschi, G., Κoutroubakis, I. E., Lindgren, S. C., López, F. D. L. M., Moum, B. A., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000442728.74340.fd · Cited by 162 · see citing works
Reducing Noninfectious Risks of Blood Transfusion
Gilliss, B. M., Looney, M. R., Gropper, M. A., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822a22d9 · Cited by 153 · see citing works
Errors of measurement for blood volume parameters: a meta-analysis
Gore, C. J., Hopkins, W. G., & Burge, C. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00505.2005 · Cited by 145 · see citing works
Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery
Miceli, A., Romeo, F., Glauber, M., de Siena, P. M., Caputo, M., & Angelini, G. D. (2014) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-9-137 · Cited by 131 · see citing works
Adlbrecht, C., Kommata, S., Hülsmann, M., Szekeres, T., Bieglmayer, C., Strunk, G., Karanikas, G., Berger, R., Mörtl, D., Kletter, K., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn359 · Cited by 125 · see citing works
Capillary versus venous haemoglobin determination in the assessment of healthy blood donors
Patel, A. J., WESLEY, R. A., Leitman, S. F., & Bryant, B. J. (2013) · Vox Sanguinis · doi:10.1111/vox.12006 · Cited by 105 · see citing works
Definition and management of anemia in patients infected with hepatitis C virus
McHutchison, J. G., Manns, M. P., & Longo, D. L. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01228.x · Cited by 104 · see citing works
Thomsen, J. K., Fogh‐Andersen, N., Bülow, K., & Devantier, A. (1991) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519109091106 · Cited by 88 · see citing works
Huber, H. P., Lewis, S. M., & Szur, L. (1964) · British Journal of Haematology · doi:10.1111/j.1365-2141.1964.tb00733.x · Cited by 80 · see citing works
Abramov, D., Cohen, R. S., Katz, S. D., MANCINI, D. M., & Maurer, M. S. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.058 · Cited by 79 · see citing works
Evaluation of diagnostic criteria in polycythemia vera
Pearson, T. C. (2001) · Seminars in Hematology · doi:10.1016/s0037-1963(01)90136-2 · Cited by 79 · see citing works
Contracted plasma and blood volume in chronic heart failure
Feigenbaum, M. S., WELSCH, M. A., Mitchell, M. J., Vincent, K. R., Braith, R. W., & Pepine, C. J. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00530-6 · Cited by 68 · see citing works
Adams, K. F., Patterson, J. H., Oren, R. M., Mehra, M. R., O’Connor, C. M., Piña, I. L., Miller, A. B., Chiong, J. R., Dunlap, S. H., Cotts, W., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.01.012 · Cited by 54 · see citing works
Anemia, inflammation and health-related quality of life in chronic kidney disease patients
Farag, Y. M. K., Keithi-Reddy, S., Mittal, B. V., Surana, S. P., Addabbo, F., Goligorsky, M. S., & Singh, A. K. (2011) · Clinical Nephrology · doi:10.5414/cnp75524 · Cited by 50 · see citing works
Carbon monoxide uptake kinetics of arterial, venous and capillary blood during CO rebreathing
Garvican, L. A., Burge, C. M., Cox, A. J., Clark, S. A., Martin, D. T., & Gore, C. J. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.054031 · Cited by 46 · see citing works
Reliability of capillary hemoglobin screening under routine conditions
Ziemann, M., Lizardo, B., Geusendam, G., & Schlenke, P. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03183.x · Cited by 44 · see citing works
Miller, W. L., & Mullan, B. P. (2015) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-015-9650-4 · Cited by 40 · see citing works
Hemoglobin assessment: precision and practicability evaluated in the Netherlands—the HAPPEN study
Baart, A. M., de Kort, W. L. A. M., van den Hurk, K., & Jong, P. C. M. P.-D. (2016) · Transfusion · doi:10.1111/trf.13546 · Cited by 34 · see citing works
Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes
Koponen, A. S., Peltonen, J. E., Päivinen, M. K., Aho, J. M., Hägglund, H., Uusitalo, A. L. T., Lindholm, H. J., & Tikkanen, H. O. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2532-4 · Cited by 32 · see citing works
Total Hemoglobin Mass, Iron Status, and Endurance Capacity in Elite Field Hockey Players
Hinrichs, T., Franke, J., Voss, S. C., Bloch, W., Schänzer, W., & Platen, P. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181a5bc59 · Cited by 31 · see citing works
Shahshahani, H. J., Meraat, N., & Mansouri, F. (2013) · PubMed · doi:10.2450/2012.0031-12 · Cited by 24 · see citing works
Analysis of Red Cell Mass and Plasma Volume in Patients With Polycythemia
Lorberboym, M., Rahimi‐Levene, N., Lipszyc, H., & Kim, C. K. (2005) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2005-129-89-aorcma · Cited by 22 · see citing works
Ahlgrim, C., Schumacher, Y. O., Wrobel, N., Waller, C. F., & Pottgießer, T. (2014) · Annals of Hematology · doi:10.1007/s00277-014-2020-5 · Cited by 18 · see citing works
Safety of the CO-Rebreathing Method in Patients with Coronary Artery Disease
Karlsen, T., Leinan, I. M., Aamot, I., Dalen, H., & Støylen, A. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000729 · Cited by 14 · see citing works
Turner, G., Richardson, A., Maxwell, N., & PRINGLE, J. S. M. (2014) · Physiological Measurement · doi:10.1088/0967-3334/35/12/n41 · Cited by 12 · see citing works
Anaemia predicts cardiovascular events in patients with stable coronary artery disease.
Lipšic, E., Asselbergs, F. W., van der Meer, P., Tio, R. A., Aa, V., van Gilst, W. H., Zijlstra, F., & Dj, V. V. (2005) · PubMed Central · Cited by 8 · see citing works
Haematological Abnormalities in Liver Disease
Senzolo, M., & Burroughs, A. K. (2007) · doi:10.1002/9780470691861.ch21c · Cited by 8 · see citing works
Prevalence of Anaemia in Decompensated Chronic Liver Disease
Kumar, E. H., & Radhakrishnan, A. (2014) · Cited by 5 · see citing works
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Elia, A., Gennser, M., Harlow, P., & Lees, M. J. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04664-x · Cited by 64 · see citing works
Myles, P. S., Richards, T., Klein, A. A., Wood, E. M., Wallace, S. K. A., Shulman, M. A., Martin, C., Bellomo, R., Corcoran, T. B., Peyton, P. J., et al. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.06.014 · Cited by 58 · see citing works
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Piccioni, F., Droghetti, A., Bertani, A., Coccia, C., Corcione, A., Corsico, A. G., Crisci, R., Curcio, C., Naja, C. D., Feltracco, P., et al. (2020) · Perioperative Medicine · doi:10.1186/s13741-020-00159-z · Cited by 46 · see citing works
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Bouten, J., Caen, K., Stautemas, J., Lefevere, F. B. D., Derave, W., Lootens, L., Eenoo, P. V., Bourgois, J., & Boone, J. (2019) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2019.04.002 · Cited by 40 · see citing works
Buzzin, A., Asquini, R., Caputo, D., & de Cesare, G. (2021) · Sensors · doi:10.3390/s21020415 · Cited by 38 · see citing works
Atkinson, T. S., & Kahn, M. J. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100632 · Cited by 31 · see citing works
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Keshavarz, A., Zangenehzadeh, S., & Hatef, A. (2020) · Applied Nanoscience · doi:10.1007/s13204-020-01252-x · Cited by 24 · see citing works
Rafiq, H. S., Fatima, B., Hussain, D., Mohyuddin, A., Majeed, S., Manzoor, S., Imran, M., Nawaz, R., Shabbir, S., Mukhtar, S., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129706 · Cited by 23 · see citing works
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Ahenkorah, B., Nsiah, K., Baffoe, P., & Anto, E. O. (2018) · BMC Hematology · doi:10.1186/s12878-018-0121-4 · Cited by 17 · see citing works
Wachsmuth, N. B., Soria, R., Jimenez, J., & Schmidt, W. (2019) · Experimental Physiology · doi:10.1113/ep087870 · Cited by 17 · see citing works
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Tetschke, M., Lilienthal, P., Pottgießer, T., Fischer, T., Schalk, E., & Säger, S. (2018) · Processes · doi:10.3390/pr6090157 · Cited by 16 · see citing works
Boulares, A., Bragazzi, N. L., Gonzales, G. F., Robach, P., Champigneulle, B., Brugniaux, J. V., Stauffer, É., Nader, É., Doutreleau, S., Connes, P., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.27761 · Cited by 14 · see citing works
Plumb, J. O. M., Kumar, S. B., Otto, J. M., Schmidt, W., Richards, T., Montgomery, H., & Grocott, M. P. W. (2018) · Physiological Reports · doi:10.14814/phy2.13829 · Cited by 12 · see citing works
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Tacon, S. L., Falaize, A., Mellati, N., Picard, Y., Goetz, C., Gette, S., & Losser, M.-R. (2023) · Burns · doi:10.1016/j.burns.2023.02.001 · Cited by 5 · see citing works
Kiebach, J., Have, J. D. V.-T., van Duijnhoven, F. J. B., Kok, D. E. G., van Lanen, A., Kouwenhoven, E. A., de Wilt, J. H. W., Schrauwen, R. W. M., Kampman, E., Winkels, R. M., et al. (2024) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-23-1048 · Cited by 5 · see citing works
Andersen, A. B., Bonne, T. C., Nordsborg, N. B., Sørensen, H., & Bejder, J. (2024) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2024.2303711 · Cited by 5 · see citing works
Díaz-Cañestro, C., Haider, T., Lundby, C., & Montero, D. (2019) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12614 · Cited by 5 · see citing works
Optimized and Personalized Phlebotomy Schedules for Patients Suffering From Polycythemia Vera
Lilienthal, P., Tetschke, M., Schalk, E., Fischer, T., & Säger, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00328 · Cited by 5 · see citing works
Khanam, S., & Khan, B. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-00858-8 · Cited by 5 · see citing works
Optical Detection of Analytes through Evanescent Waves in Lab-on-Chip Devices
Buzzin, A., Asquini, R., Caputo, D., & de Cesare, G. (2021) · International Convention on Information and Communication Technology, Electronics and Microelectronics · doi:10.23919/mipro52101.2021.9597132 · Cited by 5 · see citing works
Tremblay, J. C., Siebenmann, C., & Stembridge, M. R. (2025) · American Journal of Human Biology · doi:10.1002/ajhb.70179 · Cited by 4 · see citing works
Rahman, A., Pronoy, T. U. H., Soha, K., Auwal, A., Hossain, M., Rashel, K. M., Gofur, M. R., Rahman, M. H., Rabi, S., Roy, T. G., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-02762-w · Cited by 4 · see citing works
Ali-Baya, G., Zenile, E., Aikins, B. O., Amoaning, R. E., Simpong, D. L., & Adu, P. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07720 · Cited by 4 · see citing works
Andersen, A. B., Baungaard, S. B., Bejder, J., Graae, J., Hristovska, A., Agerskov, M., Sørensen, H., & Foss, N. B. (2022) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-022-00921-2 · Cited by 4 · see citing works
Plumb, J. O. M., Otto, J. M., Kumar, S. B., Bali, S., Wakatsuki, M., Schmidt, W., Montgomery, H., Grocott, M. P. W., & Levett, D. Z. H. (2023) · Perioperative Medicine · doi:10.1186/s13741-023-00319-x · Cited by 4 · see citing works
Self-citationWakeham, D. J., Hearon, C. M., & Levine, B. D. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00706.2023 · Cited by 3 · see citing works
Self-citationFrom Droplet to Diagnosis: Spatio‐Temporal Pattern Recognition in Drying Biofluids
Pal, A., Gope, A., & Yanagisawa, M. (2025) · Advanced Intelligent Systems · doi:10.1002/aisy.202500550 · Cited by 3 · see citing works
Moghadam, S. A., Shahmohammadi, A., Salehi, K., Javid, R. N., Soltani, P., Zafarmandi, S., Shafieyoun, M. H., Mahalleh, M., Ahmed, R., Bekfani, T., et al. (2026) · ESC Heart Failure · doi:10.1093/eschf/xvag027 · Cited by 4 · see citing works
Min, S. H., Schnall, R., Lee, C., & Topaz, M. (2023) · Journal of Aging and Health · doi:10.1177/08982643231172230 · Cited by 3 · see citing works
Alkhaldy, H. Y. M., Alqahtani, M. M., Amri, M. S. A., Alasmari, Y. D., Ghazy, R. M., & AlShehri, M. A. (2025) · Medicine · doi:10.1097/md.0000000000042762 · Cited by 3 · see citing works
Kubik, T., Hou, M., Traverse, T., Lareau, M., Jenei, V., Oberding, L., Pillai, D. R., Gillrie, M. R., Suryanarayan, D., Sidhu, D. S., et al. (2021) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2021-0368-sa · Cited by 3 · see citing works
Blood volume and hemoglobin mass in long-term heart transplant recipients with and without Anemia
Seiler, F., Ahlgrim, C., Birkner, P., Wrobel, N., Rilinger, J., Grundmann, S., Bode, C., & Pottgießer, T. (2021) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-021-01510-1 · Cited by 2 · see citing works
Gbadago, B. K., Antiaye, J., Boachie, J., & Adu, P. (2023) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2023.102757 · Cited by 2 · see citing works
Jia, Q., Peng, L., Sun, L., Jia, W., Pan, Y., Yuan, B., Wang, Y., Zhou, Q. G., Meng, X., Jing, J., et al. (2024) · Stroke and Vascular Neurology · doi:10.1136/svn-2023-002644 · Cited by 2 · see citing works
Effects of Five Serial Apnoeas Prior to a Running Time Trial in Competitive Athletes
Barlow, M., Ross, C., Cockrell, R., Rubie, M., Cahill, H., Robertson, C., French, J., & Elia, A. (2024) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-024-00296-7 · Cited by 2 · see citing works
Vinje, V., Bomholt, T., Lundby, C., Oturai, P., Rix, M., Lindhard, K., & Hornum, M. (2023) · Hemodialysis International · doi:10.1111/hdi.13118 · Cited by 2 · see citing works
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Sotiridis, A., Dardamanis-Aidonas, C., Makris, A., Loukas, I., Geladas, N., & Koskolou, M. (2026) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2025.104505 · Cited by 1 · see citing works
Alkhaldy, H. Y. M., Alqahtani, M. M., Amri, M. A., Alasmari, Y. D., Alassiri, Y., Algathradi, M. A., Ghamdi, B. A., Almalki, J., Almalki, M., Assiri, A., et al. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s567360 · Cited by 1 · see citing works
Crossing the line: blood transfusion thresholds in ECMO
Rajšić, S., Tonna, J. E., & Shekar, K. (2025) · Critical Care · doi:10.1186/s13054-025-05792-y · Cited by 1 · see citing works
Con: Restrictive Transfusion Triggers Are Better Than Liberal Ones
Scărlătescu, E. (2025) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2025.09.026 · Cited by 1 · see citing works
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Santosa, B., Anggraini, H., Mawarni, I. D., Muliatun, N., Nugroho, A., Syarah, U., & Risqoeni, S. A. (2020) · Jurnal Teknologi Laboratorium · doi:10.29238/teknolabjournal.v9i2.213 · Cited by 1 · see citing works
Liberal or restrictive transfusion for VV ECMO
Li, Y., Zhang, Y., & Wu, X. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00477-5 · Cited by 1 · see citing works
Blut: Auch ein Thema der Bayreuther Sportökonomie?
Schmidt, W. (2020) · Springer eBooks · doi:10.1007/978-3-658-28672-9_5
Self-citationPerinatal Outcomes in Pregnant Women with Anemia of Various Geneses
Radzinsky, V., Гасанова, Б. М., Polina, M., Douglas, N. I., Bulshiy, I. S., Chotchayeva, F., & Dedy, T. (2020) · International Journal of Biomedicine · doi:10.21103/article10(3)_oa8
Pregnancy and Anemia of Various Origin: Effectiveness of a Differentiated Approach
Гасанова, Б. М., Republic of Dagestan, M., & Polina, M. L. (2020) · Doctor Ru · doi:10.31550/1727-2378-2020-19-8-25-31
He, H., Zeng, M., Chen, J., Deng, L., & Chen, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-133531/v2
مستوى الهیموجلوبین فى الدم وعلاقته بالأداء المعرفى والنفسى العصبى لدى الأسویاء من الجنسین
متولی, م. م. (2021) · المجلة المصرية لعلم النفس الإکلينيکي والإرشادي · doi:10.21608/pshj.2021.195451
He, H., Zeng, M., Chen, J., Deng, L., & Chen, Y. (2020) · Research Square · doi:10.21203/rs.3.rs-133531/v1
STATISTICAL MODELLING OF HAEMOGLOBIN LEVEL IN UNDER FIVE YEARS OLD CHILDREN IN NIGERIA
Oladimeji, D., & Oguntade, E. S. (2023) · FUDMA Journal of Sciences · doi:10.33003/fjs-2022-0605-1024
Schmidt, W., & Ahlgrim, C. (2024) · Clinical Case Reports · doi:10.1002/ccr3.9071
Self-citationMin, S. H., Topaz, M., Lee, C., & Schnall, R. (2025) · Clinical Nursing Research · doi:10.1177/10547738251344980
Malczewska‐Lenczowska, J., Klusiewicz, A., Rębiś, K., Czaplicki, A., Kowalski, T., Granda, D., Starczewski, M., & Konopka, M. A. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05955-3
Structural Features and Properties of Transferrins: A Review
Klimov, D. A., & Levashov, P. A. (2025) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683825600903
Cholifah, Hadju, V., Ahmad, M., As’ád, S., & Sudirman, J. (2025) · The North African Journal of Food and Nutrition Research · doi:10.51745/najfnr.9.20.236-248
Plumb, J. O. M., Otto, J. M., Kumar, S. B., Bali, S., Wakatsuki, M., Schmidt, W. F. J., Montgomery, H., Grocott, M. P. W., & Levett, D. Z. H. (2024) · Figshare · doi:10.6084/m9.figshare.26601538
Self-citationWen, Z., Long, J., Zhu, L., Liu, S., Zeng, X., Huang, D., Qiu, X., & Su, L. (2024) · Figshare · doi:10.6084/m9.figshare.26623675
Abolyazed, A. A. M., Elbehery, W. A., Elsayed, H. M., ElSheeta, Y. H., & Elnemr, A. Y. (2026) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-026-01407-w
Dostal, J. (2026) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2026.10
Alshehri, M. A., & Alkhaldy, H. Y. M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155833
Cheng, Y.-H., Chen, H.-Y., Chou, J.-Y., Yeh, C.-C., Wu, H., & Tsai, Y.-W. (2026) · doi:10.2196/preprints.104421
- Authors
- Otto, J. M., Plumb, J. O. M., Clissold, E., Kumar, S. B., Wakeham, D. J., Schmidt, W., Grocott, M. P. W., Richards, T., & Montgomery, H. E.
- Affiliations
- University College London (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Cardiff Metropolitan University (GB)
- University of Bayreuth (DE)
- National Institute for Health and Care Research (GB)
- Corresponding author
- Richards, Toby
- ORCID
- Venue
- Haematologica
- Published
- 2017-06-08
- Volume
- 102
- Issue
- 9
- Pages
- 1477-1485
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- PMC
- PMC5685237
- OpenAlex
- W2622357367
- Cited by
- 93
- References
- 45
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 7 · 2017: 2
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Haematologica (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ERef Bayreuth (University of Bayreuth) (submittedVersion)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (ACF-2013-26-006, 10/104/06)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- anemia, hemoglobin levels, total hemoglobin mass, plasma volume, carbon monoxide rebreathing, inflammatory bowel disease, chronic liver disease, heart failure, surgical patients, healthy volunteers
- MeSH terms
- Adult, Anemia, Female, Heart Failure, Hemoglobins, Humans, Male, Middle Aged, Plasma Volume
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