Cited by 93Iron Metabolism and DisordersBlood transfusion and managementHemoglobinopathies and Related Disorders

Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia

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Otto, James M., Plumb, James O.M., Clissold, Eleri, Kumar, Shriya B., Wakeham, Denis J., Schmidt, Walter, Grocott, Michael P.W., Richards, Toby +1 more·2017·Haematologica

Abstract

In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l−1 in non-pregnant females and < 130 g.l−1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, measuring hemoglobin concentration, total hemoglobin mass (optimized carbon monoxide rebreathing method) and thereby calculating plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r=0.687–0.871, P

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  1. [36]Gonzalez-Casas R Jones EA Moreno-Otero R Spectrum of anemia associated with chronic liver disease. World J Gastroenterol. 2009; 15(37): 4653– 4658. 19787828 PMC2754513

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Authors
Otto, J. M., Plumb, J. O. M., Clissold, E., Kumar, S. B., Wakeham, D. J., Schmidt, W., Grocott, M. P. W., Richards, T., & Montgomery, H. E.
Affiliations
  • University College London (GB)
  • University Hospital Southampton NHS Foundation Trust (GB)
  • Cardiff Metropolitan University (GB)
  • University of Bayreuth (DE)
  • National Institute for Health and Care Research (GB)
Corresponding author
Richards, Toby
Venue
Haematologica
Published
2017-06-08
Volume
102
Issue
9
Pages
1477-1485
ISSN
  • 0390-6078 (ISSN-L)
  • 1592-8721
OpenAlex
W2622357367
Cited by
93
References
45
Citations by year
2026: 5 · 2025: 13 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 7 · 2017: 2
FWCI
6.93
Type
journal article
Language
en
Open access
Locations
  • Haematologica (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • ERef Bayreuth (University of Bayreuth) (submittedVersion)
Funders
  • Wellcome Trust
  • National Institute for Health and Care Research (ACF-2013-26-006, 10/104/06)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
anemia, hemoglobin levels, total hemoglobin mass, plasma volume, carbon monoxide rebreathing, inflammatory bowel disease, chronic liver disease, heart failure, surgical patients, healthy volunteers
MeSH terms
Adult, Anemia, Female, Heart Failure, Hemoglobins, Humans, Male, Middle Aged, Plasma Volume

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