Effect of the use of Chia (Salvia Hispanica L.) seeds on antioxidant status and anthropometric parameters in obese, type 2 diabetics and/or hypertensive patients
Open accessAbstract
Background and aims: Chia seeds have been explored owing to its dense concentrations of antioxidant and anti-inflammatory compounds, as well as recognized benefit on anthropometric measures. This study evaluated the potential effect of Chia intake on plasma antioxidant status and anthropometric parameters in individuals with chronic diseases. Methods: Fifty-nine participants were selected, including patients with Type 2 Diabetes Mellitus (T2DM) and/or hypertension (SAH) and/or obesity (group A, n=34) and healthy volunteers (group B, n=25). Plasma antioxidant status was determined by the MTT (tetrazolium salt) reduction test and weight (W), abdominal circumference (AC), waist circumference (WC) and body mass index (BMI), that were determined before (T0) and after 6 months (T6) of ingestion of 20 g/day of Chia seeds. Results: After Chia seeds consumption, the plasma antioxidant potential increased in both group A and group B (p < 0.0001). It was also observed a reduction in W, AC, WC and BMI in both groups, with all p-values being less than 0.05. High content of antioxidant compounds may explain these effects and polysaccharide gel formation in the digestive tract, which gives satiety and consequently provides a reduction in anthropometric measurements. Conclusion: In the field of nutrition, the chia seed can be a potential alternative to increase antioxidant status and reduce anthropometric measurements, improving the health status of patients, especially those who suffer from chronic disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chia seeds possess anti-inflammatory and antioxidant properties.
“Additionally, chia seeds possess anti-inflammatory and antioxidant properties, further contributing to their therapeutic potential [11–13].”
From Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs (2024) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works
Dietary Bioactive Compounds and Their Health Implications
Liu, R. H. (2013) · Journal of Food Science · doi:10.1111/1750-3841.12101 · Cited by 538 · see citing works
Characterization of chia seed oils obtained by pressing and solvent extraction
Ixtaina, V. Y., Martínez, M. L., Spotorno, V. G., Mateo, C. M., Maestri, D., Diehl, B. W. K., Nolasco, S. M., & Tomás, M. C. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.08.006 · Cited by 437 · see citing works
The Chemical Composition and Nutritional Value of Chia Seeds—Current State of Knowledge
Kulczyński, B., Kobus-Cisowska, J., Taczanowski, M., Kmiecik, D., & Gramza-Michałowska, A. (2019) · Nutrients · doi:10.3390/nu11061242 · Cited by 382 · see citing works
Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review
Ullah, R., Nadeem, M., Khalique, A., Imran, M., Mehmood, S., Javid, A., & Hussain, J. (2016) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1967-0 · Cited by 365 · see citing works
Characterization of phenolic compounds in chia (Salvia hispanica L.) seeds, fiber flour and oil
Oliveira-Alves, S. C., Vendramini-Costa, D. B., Betim Cazarin, C. B., Maróstica Júnior, M. R., Borges Ferreira, J. P., Silva, A. B., Prado, M. A., & Bronze, M. R. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.04.002 · Cited by 192 · see citing works
Chemical composition of Brazilian chia seeds grown in different places
da Silva, B. P., Anunciação, P. C., Matyelka, J. C. D. S., Lúcia, C. M. D., Martino, H. S. D., & Pinheiro-Sant’Ana, H. M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.10.115 · Cited by 188 · see citing works
Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Poudyal, H., Panchal, S. K., Ward, L. C., & Brown, L. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.014 · Cited by 170 · see citing works
Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus
Lorber, D. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s61438 · Cited by 168 · see citing works
Macrophages in vascular inflammation and atherosclerosis
Cochain, C., & Zernecke, A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1941-y · Cited by 164 · see citing works
Antioxidant potential of dietary chia seed and oil ( Salvia hispanica L.) in diet-induced obese rats
Marineli, R. D. S., Lenquiste, S. A., Moraes, É. A., & Maróstica, M. R. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.039 · Cited by 157 · see citing works
Chia seed does not promote weight loss or alter disease risk factors in overweight adults
Nieman, D. C., Cayea, E. J., Austin, M. D., Henson, D. A., McAnulty, S. R., & Jin, F. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.05.011 · Cited by 146 · see citing works
Supplementation of Milled Chia Seeds Increases Plasma ALA and EPA in Postmenopausal Women
Jin, F., Nieman, D. C., Sha, W., Xie, G., Qiu, Y., & Jia, W. P. (2012) · Plant Foods for Human Nutrition · doi:10.1007/s11130-012-0286-0 · Cited by 143 · see citing works
Wiltgen, D., Benedetto, I. G., Mastella, L. S., & Spritzer, P. M. (2009) · Human Reproduction · doi:10.1093/humrep/dep072 · Cited by 138 · see citing works
Vuksan, V. V. V., Jenkins, A. L., Dias, A. G., Lee, A. S., Jovanovski, E., Rogovik, A. L., & Hanna, A. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.159 · Cited by 128 · see citing works
Vuksan, V. V. V., Choleva, L., Jovanovski, E., Jenkins, A. L., Au‐Yeung, F., Dias, A. G., Ho, H. V. T., Zurbau, A., & Duvnjak, L. S. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.148 · Cited by 105 · see citing works
Chia Seed Supplementation and Disease Risk Factors in Overweight Women: A Metabolomics Investigation
Nieman, D. C., Gillitt, N., Jin, F., Henson, D. A., Kennerly, K., Shanely, R. A., Ore, B., Su, M., & Schwartz, S. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0443 · Cited by 104 · see citing works
Malta, D. C., Andrade, S. C. D. A., Claro, R. M., Bernal, R. T. I., & Monteiro, C. A. (2014) · Revista Brasileira de Epidemiologia · doi:10.1590/1809-4503201400050021 · Cited by 102 · see citing works
Ho, H. V. T., Lee, A. S., Jovanovski, E., Jenkins, A. L., deSouza, R., & Vuksan, V. V. V. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.103 · Cited by 76 · see citing works
(2017) · PubMed · Cited by 76 · see citing works
Xanthis, V., Fitsiou, E., Voulgaridou, G.-P., Bogadakis, A., Chlichlia, K., Galanis, Α., & Pappa, A. (2021) · Antioxidants · doi:10.3390/antiox10010127 · Cited by 73 · see citing works
Toscano, L. T., Toscano, L. T., Tavares, R. L., Silva, C. S. D. O., & Silva, A. S. (2014) · PubMed · doi:10.3305/nh.2015.31.3.8242 · Cited by 62 · see citing works
Effects of chia (Salvia hispanica L.) on calcium bioavailability and inflammation in Wistar rats
da Silva, B. P., Toledo, R. C. L., Grancieri, M., Moreira, M. E. D. C., Medina, N. R., Silva, R. R., Costa, N. M. B., & Martino, H. S. D. (2018) · Food Research International · doi:10.1016/j.foodres.2018.08.078 · Cited by 52 · see citing works
Determination of the antioxidant status of plasma from type 2 diabetic patients
Medina, L. O., Veloso, C. A., Borges, E. A., Isoni, C. A., Calsolari, M. R., Chaves, M. M., & Nogueira‐Machado, J. A. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.12.008 · Cited by 31 · see citing works
Antioxidant capacity of Mexican chia (Salvia hispanica L.) protein hydrolyzates
Chim-Chi, Y., Tintoré, S. G., Jiménez‐Martínez, C., Dávila-Ortíz, G., & Chel‐Guerrero, L. (2017) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-017-9644-9 · Cited by 28 · see citing works
Duarte, R. C. F., Gonçalves, L. H., Campos, F. M. F., Martins‐Filho, O. A., Alves, M. T., Fernandes, A. P., Borges, K. B. G., Dusse, L. M. S., Faria, M. C., Gonçalves, G. S., et al. (2014) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000199 · Cited by 25 · see citing works
Self-citationFerreira, M. D. R., Oliva, M. E., Aiassa, V., & D’Alessandro, M. E. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103775 · Cited by 23 · see citing works
Fortino, M. A., Oliva, M. E., Rodríguez, S. G., Lombardo, Y. B., & Chicco, A. G. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.11.003 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Coelho, M.S. & Salas-Mellado, M.D.L.M. (2014). Chemical Characterization of CHIA (Salvia hispanica L.) for Use in Food Products. Journal of Food and Nutrition Research 2: 263-269.
- Grancieri, M., Duarte, M.H.S., Gonzalez, M.E. (2019). Chia seed (Salvia hispanica L.) as a source of proteins and bioactive peptides with health benefits: A review. Rev Food Sci 18:480-499.
- Valdivia-López, MÁ, Tecante, A. (2015). Chia (Salvia hispanica L.): A Review of Native Mexican Seed and its Nutritional and Functional Properties. Adv Food Nutr Res 75:53-75.
Cited by
Sorted by citations
Chia—The New Golden Seed for the 21st Century: Nutraceutical Properties and Technological Uses
Orona‐Tamayo, D., & Paredes‐López, O. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91652-3.00005-8 · Cited by 29 · see citing works
Karimi, M., Pirzad, S., Shirsalimi, N., Ahmadizad, S., Hashemi, S. M., Karami, S., Kazemi, K., Shahir-Roudi, E., & Aminzadeh, A. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00847-3 · Cited by 25 · see citing works
Fateh, H. L., Ahmed, D. H., Najafabadi, M. S., & Moludi, J. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106907 · Cited by 15 · see citing works
Huang, M., Xu, H., Zhou, Q., Xiao, J., Su, Y., & Wang, M. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2337220 · Cited by 12 · see citing works
de Souza, A. Á., Lima, A. M., dede Oliveira BezerraSousa, D., Nogueira, F. C., do Sacramento Neto, J. C., Dias, L. P., Araújo, N. M. S., Nagano, C. S., Júnior, H. V. N., da Silva, C. R., et al. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09979-5 · Cited by 8 · see citing works
FaragAllah, E. M., Algharib, S. A., Goda, N. I. A., El-Malkey, N. F., Mahboub, H. H. H., El‐Fayoumi, S. H., Al‐Hoshani, N., Wahid, R. M., & Aref, M. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102156 · Cited by 8 · see citing works
Tanisha, Venkategowda, S., & Majumdar, M. (2023) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2023.07.002 · Cited by 8 · see citing works
Tanisha, Venkategowda, S., & Majumdar, M. (2022) · 3 Biotech · doi:10.1007/s13205-022-03309-w · Cited by 6 · see citing works
Kiani, S., Naghshi, S., & Saghafi‐Asl, M. (2024) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2024.103086 · Cited by 5 · see citing works
Shahparvari, M. R., & Nasrollahzadeh, J. (2024) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13369 · Cited by 3 · see citing works
Parimi, M., Arefhosseini, S., Tutunchi, H., Arefhosseini, S. R., & Ebrahimi‐Mameghani, M. (2025) · International Journal of Clinical Practice · doi:10.1155/ijcp/8660821 · Cited by 1 · see citing works
Biologically Active Peptides from Chia (Salvia hispanica L.) Seed
Briceño-Islas, G., & Urías‐Silvas, J. E. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815123340123040016
Karimi, M., Pirzad, S., Shirsalimi, N., Ahmadizad, S., Hashemi, S. M., Karami, S., Kazemi, K., Shahir-Roudi, E., & Aminzadeh, A. (2024) · Figshare · doi:10.6084/m9.figshare.27042480
Health-promoting properties of chia
Muñoz, L. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24865-8.00008-6
- Authors
- Lovato, A. D. C., Corgozinho, M. L. M. V., Alves, L. V., Martins, S. R., Duarte, R. C. F., Cardoso, C. N., Silvino, J. P. D. P., Ferreira, C. N., Silva, I. D. F. O., & Mota, A. P. L.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- ORCID
- Venue
- Research, Society and Development
- Publisher
- Research, Society and Development
- Published
- 2022-03-24
- Volume
- 11
- Issue
- 4
- Pages
- e46511427432
- ISSN
- 2525-3409 (ISSN-L)
- OpenAlex
- W4221077890
- Cited by
- 14
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 2
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Research Society and Development (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade Federal de Minas Gerais
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Salvia hispanica, plasma antioxidant status, anthropometric parameters, obesity, type 2 diabetes, hypertension, chronic disease, dietary supplementation, satiety, polysaccharides, body mass index, waist circumference, abdominal circumference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review