The First Human Case of Hepatic Dirofilariasis
Open accessAbstract
Most of human dirofilariasis are pulmonary or subcutaneous infections, but there have been a few reports of human dirofilariasis in unusual sites, such as large vessels, mesentery, peritoneal cavity, and spermatic cord. We present the first case of human hepatic dirofilariasis, which was surgically diagnosed. A 39-year-old man without any evidence of systemic symptom was found incidentally to have a hepatic nodule during routine physical check-up. The histologic findings of the resected lesion showed a granulomatous lesion with central necrosis containing up to 35 transverse sections of a nematode, ranging 30-80 micro m in diameter. Thin (1.5-5 micro m) cuticle with transverse striations surrounded polymyarian and muscle bundles occupied a sixth of both sides of outer body cavity. Central portion of the body cavity was occupied with an intestine-like tubular structure and a larger reproductive tube. These microscopic findings were consistent with degenerated Dirofilaria immitis. Antibody test by enzyme-linked immunosorbent assay for patient serum reacted positively against adult D. immitis antigen.
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Ocular and subcutaneous infections are usually caused by D. repens, while D. immitis is involved in pulmonary dirofilariasis in humans.
“Ocular and subcutaneous infections are usually caused by D. repens , while D. immitis is involved in pulmonary dirofilariasis in humans [7,9].”
From Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country (2015) · cites this paper as [9]
In humans, dirofilariasis manifests as subcutaneous nodule, ocular or pulmonary dirofilariasis, and there are reports of unusual body sites including orbital area, liver, spermatic cord and abdominal cavity.
“In humans, the disease manifests as a subcutaneous nodule, ocular or pulmonary dirofilariasis, but there are several reports about presentation in unusual body sites as well, including orbital area, liver, spermatic cord and abdominal cavity [8-11].”
From Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country (2015) · cites this paper as [9]
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- Authors
- Kim, M. K., Kim, C. H., Yeom, B. W., Park, S. H., Choi, S. Y., & Choi, J. S.
- Affiliations
- Korea University (KR)
- Venue
- Journal of Korean Medical Science
- Publisher
- Korean Academy of Medical Sciences
- Published
- 2002
- Volume
- 17
- Issue
- 5
- Pages
- 686
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- PMC
- PMC3054933
- OpenAlex
- W2021523457
- Cited by
- 46
- References
- 11
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Korean Medical Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Keywords
- Dirofilaria immitis, filariasis, granuloma, liver nodules, surgical diagnosis, nematode morphology, antibody serology
- MeSH terms
- Adult, Animals, Dirofilaria immitis, Dirofilariasis, Humans, Liver Diseases, Parasitic, Male
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