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Cited by 96Parasitic Diseases Research and TreatmentHelminth infection and controlResearch on Leishmaniasis Studies

Dirofilarial human cases in the Old World, attributed to Dirofilaria immitis : a critical analysis

Pampiglione, Silvio, Rivasi, Francesco, Gustinelli, Andrea·2009·Histopathology
DOI 10.1111/j.1365-2559.2008.03197_a.x
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Abstract

Aims: To review 28 cases of human dirofilariasis reported in the last 30 years in the Old World and attributed, by their respective authors, to Dirofilaria immitis or a species of Dirofilaria other than D. repens. Methods and results: Each case was analysed by examining the published accounts or by discussions with the authors, who were interviewed whenever possible. Conclusions: On the basis of these analyses we conclude that there is as yet no proof demonstrating with certainty that Old World D. immitis plays a pathogenic role in humans. It remains to be explained why D. immitis causes pulmonary infections in humans in the Americas while, in the Old World, this location appears, instead, to be always associated with D.repens, even though the former species is at times more frequent than the latter both in dogs and in the vectors. To explain this apparently different pathogenic power, two hypotheses are proposed: (i) there are perhaps twin populations with different genotypes on the two sides of the Atlantic, with different infective capacity for man and dog; (ii) the infective capacity to humans of the parasite could be modified, only in the Old World, by some unidentified factor, possibly inherent to the vector, that affects the complex mechanism of the vector–parasite relationship, affecting the survival of the larvae.

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Crossref · 10.1111/j.1365-2559.2008.03197_a.x

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57 of 57 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dirofilaria repens is the main agent of human dirofilariosis.

    “whereas D. repens, causing subcutaneous infestation in dogs, is the main agent of human dirofilariosis.”

    From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [88]

  • Dirofilaria repens has been accounted for a long time as the sole species that infests humans in Europe.

    “While D. immitis is the main agent of human dirofilariosis in the Americas [28,66], D. repens has been accounted for a long time as the sole species that infest humans in Europe [87,88].”

    From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [88]

  • Questionable identification of the species causing dirofilariatic nodules can be due to alterations in parasite structures or decomposition of worms inside nodules.

    “A questionable identification of the species causing dirofilariatic nodules (330) can be due to alterations in the parasite structures or to the decomposition of worms inside nodules.”

    From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [330]

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Authors
Pampiglione, S., Rivasi, F., & Gustinelli, A.
Affiliations
  • University of Bologna (IT)
  • University of Modena and Reggio Emilia (IT)
ORCID
Gustinelli, Andrea
Venue
Histopathology
Publisher
Wiley
Published
2009-01
Volume
54
Issue
2
Pages
192-204
ISSN
  • 0309-0167 (ISSN-L)
  • 1365-2559
DOI
10.1111/j.1365-2559.2008.03197_a.x
OpenAlex
W1967159460
Cited by
96
References
57
Citations by year
2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 8
FWCI
7.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations
  • Histopathology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords
Dirofilaria immitis, Dirofilaria repens, human dirofilariasis, Old World, pulmonary dirofilariasis, pathogenicity, species misidentification, canine filariasis
MeSH terms
Animals, Dirofilaria immitis, Dirofilariasis, Humans, Liver Diseases, Parasitic, Lung Diseases, Parasitic, Skin Diseases, Parasitic, Eye Infections, Parasitic

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