Subclinical Hypothyroidism has Little Influences on Muscle Mass or Strength in Elderly People
Open accessAbstract
Sarcopenia, the age-related decline in muscle mass, affects the muscle strength and muscle quality, and these changes decrease functional capacity. The prevalence of thyroid dysfunction increases with age, and changes in thyroid hormone level lead to neuromuscular deficits. We investigated the effects of subclinical hypothyroidism on the muscle mass, strength or quality in elderly people. One thousand one hundred eighteen subjects aged > or = 65 yr were randomly selected from a local population and classified into a euthyroid (280 men and 358 women), subclinically hypothyroid (61 men and 75 women), or overtly hypothyroid (7 men and 16 women) group. Although women with subclinical hypothyroidism had a higher prevalence of sarcopenia, defined according to the ratio of appendicular skeletal muscle mass to the square of height, muscle mass, strength or quality did not differ in relation to thyroid status in men or in women. Multivariate analysis including age, diabetes, hypertension, acute coronary event, alcohol, smoking, presence of pain, physical activity score, and lipid profile, showed that thyroid-stimulating hormone level was not associated with muscle mass, strength or quality. In conclusion, subclinical hypothyroidism has little influences on muscle mass, strength or quality, and may not be associated with sarcopenia.
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In older adults, subclinical hyperthyroidism is not associated with low muscle mass and/or strength.
“However, in older adults, subclinical hyperthyroidism was not associated with low muscle mass and/or strength (121–123)”
From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [121]
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Self-citation
- Authors
- Moon, M. K., Lee, Y. J., Choi, S. H., Lim, S., Yang, E. J., Lim, J.-Y., Paik, N.-J., Kim, K. W., Park, K. S., Jang, H. C., Cho, B. Y., & Park, Y. J.
- Affiliations
- Seoul National University (KR)
- National Cancer Center (KR)
- Seoul National University Bundang Hospital (KR)
- Corresponding author
- Cho, Bo Youn
- Park, Young Joo
- ORCID
- Venue
- Journal of Korean Medical Science
- Publisher
- XMLink
- Published
- 2010
- Volume
- 25
- Issue
- 8
- Pages
- 1176
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- PMC
- PMC2908787
- OpenAlex
- W2109973781
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Korean Medical Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Korea Science and Engineering Foundation (M10642140004-06N4214-00410)
- Ministry of Education, Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- subclinical hypothyroidism, sarcopenia, muscle mass, muscle strength, muscle quality, older adults, thyroid-stimulating hormone, overt hypothyroidism, sex differences, functional capacity
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Diabetes Mellitus, Female, Humans, Hypertension, Hypothyroidism, Male, Surveys and Questionnaires, Smoking, Exercise, Muscle, Skeletal, Muscle Strength, Sarcopenia
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