Fatal Cases of 2009 Pandemic Influenza A (H1N1) in Korea
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The aim of this study was to describe the features of deaths associated with the 2009 pandemic influenza A (H1N1) by 26 November 2009 in Korea. We collected standardized case reports on 115 confirmed deaths through a nationwide enhanced influenza surveillance system. The median age was 61 yr (interquartile range [IQR], 0.2-97 yr) and 58 (50.4%) were females. The case fatality rate was estimated as 16 per 100,000 cases. The age-related mortality rate had a J-shaped curve. Eighty-three patients (72.2%) had at least 1 underlying medical disease. Bacterial co-infections were detected in the blood or sputum specimens from 34 patients. Of the 63 patients who were hospitalized in the intensive care unit (ICU), the median time from symptom onset to hospital admission was 2 days (IQR, 0-22 days), and the median time from hospitalization to ICU admission was 1 day (IQR, 0-17 days). Neuraminidase inhibitors were administered to 100 patients (87.0%), 36% of whom began treatment within 2 days. In conclusion, fatal cases from the 2009 influenza A (H1N1) infection in Korea are mainly aged individuals with underlying disease, and associated with pneumonia, bacterial co-infections, and multi-organ failure.
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In the Korean study of standardised case reports of A(H1N1)pdm09-associated deaths, the estimated ILI case-fatality rate was 16 per 100,000 cases.
“The Korean study of standardised case reports of A(H1N1)pdm09-associated deaths identified during a period of active surveillance estimated ILI case-fatality rate to be 16 per 100,000 cases [20].”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [20]
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- Authors
- Kim, H. S., Kim, J. H., Shin, S. Y., Kang, Y. A., Lee, H. G., Kim, J. S., Lee, J. K., & Cho, B.
- Affiliations
- Korea Disease Control and Prevention Agency (KR)
- Seoul National University (KR)
- Corresponding author
- Cho, Belong
- Venue
- Journal of Korean Medical Science
- Publisher
- Korean Academy of Medical Sciences
- Published
- 2011
- Volume
- 26
- Issue
- 1
- Pages
- 22
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- PMC
- PMC3012845
- OpenAlex
- W2087904452
- Cited by
- 36
- References
- 20
- Citations by year
- 2023: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 11
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Korean Medical Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- 2009 pandemic influenza A (H1N1), influenza mortality, case fatality rate, age-related mortality, comorbidities, bacterial co-infection, pneumonia, multiple organ failure, neuraminidase inhibitors, intensive care unit admission, Korea
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents, Bacterial Infections, Child, Child, Preschool, Female, Humans, Infant, Influenza, Human, Male, Middle Aged, Influenza A Virus, H1N1 Subtype, Oseltamivir, Republic of Korea, Pandemics
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