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Cited by 466

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Calprotectin – a pleiotropic molecule in acute and chronic inflammation.

Open access
Stříž, I, Trebichavský, I·2004·Physiological Research
DOI 10.33549/physiolres.930448
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Abstract

Calprotectin (MRP8/14, S100A8/S100A9, 27E10 antigen) is a heterodimer of two calcium-binding proteins present in the cytoplasm of neutrophils and expressed on the membrane of monocytes. Upon neutrophil activation or endothelial adhesion of monocytes, calprotectin is released and may be detected in serum or body fluids as potentially useful clinical inflammatory marker. The soluble form of calprotectin provides both bacteriostatic and cytokine-like effects in the local environment. When calprotectin metabolism is affected on a systemic level, the zinc-binding properties of protein may induce severe dysregulation of zinc homeostasis with severe clinical symptoms. The distribution of membrane form of calprotectin is restricted to monocytes and immature macrophages and the presence of calprotectin-positive infiltrating cells reflects the influx of mononuclear phagocytes to the site of inflammation. Calprotectin expression and release seems to be of particular importance in immune and immunopathological reactions.

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Metadata

Authors
Stříž, I., & Trebichavský, I.
Venue
Physiological Research
Publisher
Institute of Physiology of the Czech Academy of Sciences
Published
2004
Volume
53
Issue
3
Pages
245-253
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
DOI
10.33549/physiolres.930448
OpenAlex
W2182047966
Cited by
466
References
42
FWCI
3.39
Type
journal article
Language
en
Open access
gold

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