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Cited by 24Peripheral Nerve DisordersNeuroscience and Neural EngineeringPeripheral Neuropathies and Disorders

In vivo measurement of conduction velocities in afferent and efferent nerve fibre groups in mice

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STEFFENS, H., DIBAJ, P., SCHOMBURG, E. D.·2012·Physiological Research
DOI 10.33549/physiolres.932248
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Abstract

Electrophysiological investigations in mice, particularly with altered myelination, require reference data of the nerve conduction velocity (CV). CVs of different fibre groups were determined in the hindlimb of anaesthetized adult mice. Differentiation between afferent and efferent fibres was performed by recording at dorsal roots and stimulating at ventral roots, respectively. Correspondingly, recording or stimulation was performed at peripheral hindlimb nerves. Stimulation was performed with graded strength to differentiate between fibre groups. CVs of the same fibre groups were different in different nerves of the hindlimb. CVs for motor fibres were for the tibial nerve (Tib) 38.5±4.0 m/s (Agamma: 16.7±3.0 m/s), the sural nerve (Sur) 39.3±3.1 m/s (12.0±0.8 m/s) and the common peroneal nerve (Per) 46.7±4.7 m/s (22.2±4.4 m/s). CVs for group I afferents were 47.4±3.1 m/s (Tib), 43.8±3.8 m/s (Sur), 55.2±6.1 m/s (Per) and 42.9±4.3 m/s for the posterior biceps (PB). CVs of higher threshold afferents, presumably muscle and cutaneous, cover a broad range and do not really exhibit nerve specific differences. Ranges are for group II 22-38 m/s, for group III 9-19 m/s, and for group IV 0.8-0.9 m/s. Incontrovertible evidence was found for the presence of motor fibres in the sural nerve. The results are useful as references for further electrophysiological investigations particularly in genetically modified mice with myelination changes.

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Authors
STEFFENS, H., DIBAJ, P., & SCHOMBURG, E. D.
Affiliations
  • University of Göttingen (DE)
  • Max Planck Institute of Experimental Medicine (DE)
ORCID
Venue
Physiological Research
Publisher
Institute of Physiology of the Czech Academy of Sciences
Published
2012-04-16
Volume
61
Issue
2
Pages
203-214
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
DOI
10.33549/physiolres.932248
OpenAlex
W2184136334
Cited by
24
References
41
Citations by year
2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2013: 2
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Physiological Research (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • GRO (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
Deutsche Forschungsgemeinschaft (SCHO 37/16)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
nerve conduction velocity, afferent nerve fibers, tibial nerve, sural nerve, peroneal nerve, ventral root stimulation, myelination, genetically modified mice, mice
MeSH terms
Action Potentials, Animals, Hindlimb, Mice, Inbred C57BL, Nerve Fibers, Neural Conduction, Synaptic Transmission, Neurons, Afferent, Neurons, Efferent, Mice

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