Spatial and functional selectivity of peripheral nerve signal recording with the transversal intrafascicular multichannel electrode (TIME)
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The selection of suitable peripheral nerve electrodes for biomedical applications implies a trade-off between invasiveness and selectivity. The optimal design should provide the highest selectivity for targeting a large number of nerve fascicles with the least invasiveness and potential damage to the nerve. The transverse intrafascicular multichannel electrode (TIME), transversally inserted in the peripheral nerve, has been shown to be useful for the selective activation of subsets of axons, both at inter- and intra-fascicular levels, in the small sciatic nerve of the rat. In this study we assessed the capabilities of TIME for the selective recording of neural activity, considering the topographical selectivity and the distinction of neural signals corresponding to different sensory types. Topographical recording selectivity was proved by the differential recording of CNAPs from different subsets of nerve fibers, such as those innervating toes 2 and 4 of the hindpaw of the rat. Neural signals elicited by sensory stimuli applied to the rat paw were successfully recorded. Signal processing allowed distinguishing three different types of sensory stimuli such as tactile, proprioceptive and nociceptive ones with high performance. These findings further support the suitability of TIMEs for neuroprosthetic applications, by exploiting the transversal topographical structure of the peripheral nerves.
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TIMEs are able to both stimulate and record from separate nerve fascicles within nerves independently.
“TIMEs are able to both stimulate (Badia et al., 2011b) and record from Badia et al. (2016) separate nerve fascicles within nerves independently, and coupled with artificial hand prostheses have been used to restore sensory perception in human hand amputee patients (Raspopovic et al., 2014; D'Anna et al., 2019).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Badia et al., 2016
Previous studies of peripheral implants used for rodents have reported peak-to-peak signal amplitudes ranging from 100-900 μV in response to electrical stimuli.
“Previous studies of peripheral implants used for rodents have reported peak-to-peak signal amplitudes ranging from 100–900 μV in response to electrical stimuli [22–27].”
From A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve (2017) · cites this paper as [26]
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- Authors
- Badia, J., Raspopovic, S., Carpaneto, J., Micera, S., & Navarro, X.
- Affiliations
- Scuola Superiore Sant'Anna (IT)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2016-01
- Volume
- 24
- Issue
- 1
- Pages
- 20-27
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W2248997372
- Semantic Scholar
- 2695bd91a0f9e88dc4fd21c78d133d02cfbecee1
- Cited by
- 65
- References
- 27
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 10 · 2017: 12 · 2016: 1 · 2015: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- European Commission
- Italian Ministry of Health (NEMESIS)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peripheral nerve recording, nerve fascicles, compound nerve action potential, sciatic nerve, neuroprosthetics
- MeSH terms
- Action Potentials, Animals, Diagnostic Techniques, Neurological, Electrodes, Equipment Design, Evoked Potentials, Somatosensory, Sciatic Nerve, Sensitivity and Specificity, Reproducibility of Results, Rats, Sprague-Dawley, Equipment Failure Analysis, Microarray Analysis, Rats, Spatio-Temporal Analysis
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