Comparison of the relative telomere length measured in leukocytes and eleven different human tissues
Open accessAbstract
The relative length of telomeres measured in peripheral blood leukocytes is a commonly used system marker for biological aging and can also be used as a biomarker of cardiovascular aging. However, to what extent the telomere length in peripheral leukocytes reflects telomere length in different organ tissues is still unclear. Therefore, we have measured relative telomere length (rTL) in twelve different human tissues (peripheral blood leukocytes, liver, kidney, heart, spleen, brain, skin, triceps, tongue mucosa, intercostal skeletal muscle, subcutaneous fat, and abdominal fat) from twelve cadavers (age range of 29 week of gestation to 88 years old). The highest rTL variability was observed in peripheral leukocytes, and the lowest variability was found in brain. We found a significant linear correlation between leukocyte rTL and both intercostal muscle (R=0.68, P<0.02) and liver rTL (R=0.60, P<0.05) only. High rTL variability was observed between different organs from one individual. Furthermore, we have shown that even slight DNA degradation (modeled by sonication of genomic DNA) leads to false rTL shortening. We conclude that the rTL in peripheral leukocytes is not strongly correlated with the rTL in different organs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The relationship of LTL to TL in other tissues has not been well established, and TL varies by tissue.
“(b) the relationship of LTL to TL in other tissues has not been well established, and TL varies by tissue (although TL is generally positively correlated across certain, but not all, tissues within individuals) (Daniali et al., 2013; Dlouha et al., 2014; Friedrich et al., 2000; Gadalla et al., 2010; Lukens et al., 2009; Mitchell et al., 2014; Nakamura et al., 2002; Takubo et al., 2002; Takubo et a”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Dlouha et al., 2014
Even slight DNA degradation can yield spurious TL measurements.
“(d) even slight DNA degradation can yield spurious TL measuements (Dlouha et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Dlouha et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
A telomerase component is defective in the human disease dyskeratosis congenita
Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709 · see citing works
García‐Cao, M., O’Sullivan, R. J., Peters, A. H. F. M., Jenuwein, T., & Blasco, M. A. (2003) · Nature Genetics · doi:10.1038/ng1278 · Cited by 557 · see citing works
Telomere length is paternally inherited and is associated with parental lifespan
Njajou, O. T., Cawthon, R. M., Damcott, C. M., Wu, S.-H., Ott, S., Garant, M. J., Blackburn, E. H., Mitchell, B. D., Shuldiner, A. R., & Hsueh, W.-C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702703104 · Cited by 387 · see citing works
Telomere length in different tissues of elderly patients
Friedrich, U., Griese, E.-U., Schwab, M., Fritz, P., Thon, K.-P., & Klotz, U. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00173-1 · Cited by 325 · see citing works
Telomere biology in healthy aging and disease
Oeseburg, H., de Boer, R. A., van Gilst, W. H., & van der Harst, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0728-1 · Cited by 273 · see citing works
Wilson, W. R. W., Herbert, K. E., Mistry, Y., Stevens, S. E., Patel, H. R., Hastings, R. A., Thompson, M. M., & Williams, B. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn386 · Cited by 185 · see citing works
Cell Senescence in the Aging Kidney
Yang, H., & Fogo, A. B. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010020205 · Cited by 158 · see citing works
Aging, telomeres, and atherosclerosis
EDO, M., & ANDRES, V (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.007 · Cited by 112 · see citing works
Strandberg, T. E., Strandberg, A. Y., Saijonmaa, O. J., Tilvis, R. S., Pitkälä, K. H., & Fyhrquist, F. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9728-0 · Cited by 95 · see citing works
Telomere Length Dynamics in Vascular Disease: A Review
Butt, H. Z., Atturu, G., London, N. J. M., Sayers, R. D., & Bown, M. J. (2010) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2010.04.012 · Cited by 95 · see citing works
Aging, telomeres and heart failure
Wong, L. S. M., van der Harst, P., de Boer, R. A., Huzen, J., van Gilst, W. H., & van Veldhuisen, D. J. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9173-7 · Cited by 74 · see citing works
Telomere length and cardiovascular disease
Saliques, S., Zeller, M., Lorin, J., Lorgis, L., Teyssier, J., Cottin, Y., Rochette, L., & Vergely, C. (2010) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2010.08.002 · Cited by 69 · see citing works
Telomere Biology and Telomere Diseases: Implications for Practice and Research
Young, N. S. (2010) · Hematology · doi:10.1182/asheducation-2010.1.30 · Cited by 64 · see citing works
Salpea, K. D., Nicaud, V., Tiret, L., Talmud, P. J., Humphries, S. E., & on behalf of the EARS II group (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0347-x · Cited by 57 · see citing works
Telomeres and Telomerase in Renal Health
Wills, L. P., & Schnellmann, R. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010060662 · Cited by 42 · see citing works
Dlouhá, D., Pitha, J. V., Lánská, V., & Hubacek, J. A. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.03.025 · Cited by 27 · see citing works
Telomere Shortening and Regenerative Capacity after Acute Kidney Injury
Wills, L. P., & Schnellmann, R. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121270 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Barthel, F. P., Wei, W., Tang, M., Martinez-Ledesma, E., Hu, X., Amin, S. B., Akdemir, K. C., Seth, S., Song, X., Wang, Q., et al. (2017) · Nature Genetics · doi:10.1038/ng.3781 · Cited by 614 · see citing works
Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454 · see citing works
Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis
Astuti, Y., Wardhana, A. P., Watkins, J. A., & Wulaningsih, W. (2017) · Environmental Research · doi:10.1016/j.envres.2017.06.038 · Cited by 329 · see citing works
Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Darrow, S. M., Verhoeven, J. E., Révész, D., Lindqvist, D., Penninx, B. W. J. H., Delucchi, K. L., Wolkowitz, O. M., & Mathews, C. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000356 · Cited by 229 · see citing works
Duckworth, A., Gibbons, M., Allen, R. J., Almond, H., Beaumont, R. N., Wood, A. R., Lunnon, K., Lindsay, M. A., Wain, L. V., Tyrrell, J., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30364-7 · Cited by 228 · see citing works
Telomere biology and age-related diseases
Herrmann, M., Pusceddu, I., März, W., & Herrmann, W. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0870 · Cited by 193 · see citing works
Kawecki, M., Łabuś, W., Klama‐Baryła, A., Kitala, D., Kraut, M., Glik, J., Misiuga, M., Nowak, M., Bielecki, T., & Kasperczyk, A. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33865 · Cited by 129 · see citing works
Genetic Susceptibility to Chronic Kidney Disease – Some More Pieces for the Heritability Puzzle
Cañadas‐Garre, M., Anderson, K., Cappa, R., Skelly, R., Smyth, L. J., McKnight, A. J., & Maxwell, A. P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00453 · Cited by 117 · see citing works
Granic, A., Suetterlin, K., Shavlakadze, T., Grounds, M. D., & Sayer, A. A. (2023) · Clinical Science · doi:10.1042/cs20230319 · Cited by 118 · see citing works
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects
Topiwala, A., Taschler, B., Ebmeier, K. P., Smith, S. M., Zhou, H., Levey, D. F., Codd, V., Samani, N. J., Gelernter, J. E., Nichols, T. E., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01690-9 · Cited by 98 · see citing works
Telomeres and Age-Related Diseases
Gruber, H., Semeraro, M. D., Renner, W., & Herrmann, M. (2021) · Biomedicines · doi:10.3390/biomedicines9101335 · Cited by 96 · see citing works
Telomere length: how the length makes a difference
Lulkiewicz, M., Bajsert, J., Kopczynski, P., Barczak, W., & Rubiś, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05551-y · Cited by 89 · see citing works
Lindrose, A. R., McLester‐Davis, L. W. Y., Tristano, R. I., Kataria, L., Gadalla, S. M., Eisenberg, D. T. A., Verhulst, S., & Drury, S. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245582 · Cited by 89 · see citing works
Telomere length and bipolar disorder
Powell, T. R., Dima, D., Frangou, S., & Breen, G. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.125 · Cited by 78 · see citing works
Huang, Y., Wang, L., Tseng, P., Hung, C., & Lin, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.035 · Cited by 73 · see citing works
Telomere length is associated with childhood trauma in patients with severe mental disorders
Aas, M., Elvsåshagen, T., Westlye, L. T., Kaufmann, T., Athanasiu, L., Djurovic, S., Melle, I. S., van der Meer, D., Martin-Ruiz, C. M., Steen, N. E., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0432-7 · Cited by 65 · see citing works
Telomeres and Longevity: A Cause or an Effect?
Shekhidem, H. A., Sharvit, L. E., Leman, E., Manov, I., Roichman, A., Holtze, S., Huffman, D. M., Cohen, H. Y., Hildebrandt, T. B., Shams, I., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133233 · Cited by 65 · see citing works
Meyer, A., Salewsky, B., Spira, D., Steinhagen‐Thiessen, E., Norman, K., & Demuth, I. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116806 · Cited by 61 · see citing works
Vrablı́k, M., Dlouhá, D., Todorovová, V., Stefler, D., & Hubacek, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084182 · Cited by 62 · see citing works
Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review
Schellnegger, M., Lin, A. C., Hammer, N., & Kamolz, L. (2022) · Sports Medicine - Open · doi:10.1186/s40798-022-00503-1 · Cited by 60 · see citing works
Increasing the accuracy and precision of relative telomere length estimates by RT qPCR
Eastwood, J. R., Mulder, G., Verhulst, S., & Peters, A. (2017) · Molecular Ecology Resources · doi:10.1111/1755-0998.12711 · Cited by 57 · see citing works
The peculiar aging of human liver: A geroscience perspective within transplant context
Morsiani, C., Bacalini, M. G., Santoro, A., Garagnani, P., Collura, S., D’Errico, A., de Eguileor, M., Grazi, G. L., Cescon, M., Franceschi, C., et al. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.02.002 · Cited by 54 · see citing works
Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder
Henje Blom, E., Han, L. K. M., Connolly, C. G., Ho, T. C., Lin, J., LeWinn, K. Z., Simmons, A. N., Sacchet, M. D., Mobayed, N., Luna, M. E., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.172 · Cited by 51 · see citing works
A review of telomere length in sarcopenia and frailty
Lorenzi, M., Bonassi, S., Lorenzi, T., Giovannini, S., Bernabei, R., & Onder, G. (2018) · Biogerontology · doi:10.1007/s10522-018-9749-5 · Cited by 52 · see citing works
Short-term dietary restriction in old zebrafish changes cell senescence mechanisms
Arslan-Ergül, A., Erbaba, B., Karoglu-Eravsar, E. T., Halim, D. O., & Adams, M. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.033 · Cited by 50 · see citing works
Physical activity, a modulator of aging through effects on telomere biology
Semeraro, M. D., Smith, C., Kaiser, M., Levinger, I., Duque, G., Gruber, H. J., & Herrmann, M. (2020) · Aging · doi:10.18632/aging.103504 · Cited by 49 · see citing works
The Importance of Telomere Shortening for Atherosclerosis and Mortality
Herrmann, W., & Herrmann, M. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7030029 · Cited by 46 · see citing works
n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease
Barden, A. E., O’Callaghan, N. J., Burke, V., Mas, E., Beilin, L. J., Fenech, M. F., Irish, A. B., Watts, G. F., Puddey, I. B., Huang, R., et al. (2016) · Nutrients · doi:10.3390/nu8030175 · Cited by 45 · see citing works
Machiela, M. J., Hofmann, J. N., Carreras‐Torres, R., Brown, K. M., Johansson, M., Wang, Z., Foll, M., Li, P., Rothman, N., Savage, S. A., et al. (2017) · European Urology · doi:10.1016/j.eururo.2017.07.015 · Cited by 45 · see citing works
Telomeres, Aging and Exercise: Guilty by Association?
Chilton, W. L., O’Brien, B. J., & Charchar, F. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122573 · Cited by 43 · see citing works
Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target
Sagris, Μ., Theofilis, P., Antonopoulos, A. S., Tsioufis, K. P., & Tousoulis, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416010 · Cited by 43 · see citing works
Courtwright, A., Fried, S., Villalba, J. A., Moniodis, A., Guleria, I., Wood, I. G., Milford, E. L., Mallidi, H. R., Hunninghake, G. M., Raby, B. A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162409 · Cited by 42 · see citing works
Zadeh, F. A., Bokov, D. O., Yasin, G., Vahdat, S., & Farhangi, M. A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1971155 · Cited by 41 · see citing works
Kim, D., Li, A. A., & Ahmed, A. (2018) · Liver International · doi:10.1111/liv.13886 · Cited by 41 · see citing works
Telomeres and Telomerase During Human Papillomavirus-Induced Carcinogenesis
Pańczyszyn, A., Boniewska‐Bernacka, E., & Głąb, G. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0336-x · Cited by 38 · see citing works
Sex‐ And tissue‐specific differences in telomere length in a reptile
Rollings, N., Friesen, C. R., Whittington, C. M., Johansson, R., Shine, R., & Olsson, M. M. (2019) · Ecology and Evolution · doi:10.1002/ece3.5164 · Cited by 37 · see citing works
Standard guidelines for the publication of telomere qPCR results in evolutionary ecology
Morinha, F., Magalhães, P. M. R., & Blanco, G. (2020) · Molecular Ecology Resources · doi:10.1111/1755-0998.13152 · Cited by 38 · see citing works
Cardiac telomere length in heart development, function, and disease
Booth, S. A., & Charchar, F. J. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2017 · Cited by 32 · see citing works
van Batenburg, A. A., Kazemier, K. M., van Oosterhout, M. F. M., van der Vis, J. J., van Es, H. W., Grutters, J. C., Goldschmeding, R., & van Moorsel, C. H. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226785 · Cited by 32 · see citing works
Telomeres and telomerase in risk assessment of cardiovascular diseases
Boniewska-Bernacka, E., Pańczyszyn, A., & Klinger, M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112361 · Cited by 31 · see citing works
Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
Muneer, A., & Minhas, F. A. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.3.343 · Cited by 31 · see citing works
Physiological mechanisms of adaptive developmental plasticity in Rana temporaria island populations
Burraco, P., Valdés, A. E., Johansson, F., & Gómez-Mestre, I. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-1004-1 · Cited by 31 · see citing works
de Rooij, S. R., van Pelt, A. M. M., Ozanne, S. E., Korver, C. M., van Daalen, S. K. M., Painter, R. C., Schwab, M. G., Viegas, M. H., & Roseboom, T. J. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112326 · Cited by 30 · see citing works
Novel contribution to clubfoot pathogenesis: The possible role of extracellular matrix proteins
Eckhardt, A., Novotný, T., Doubková, M., Hronkova, L., Vajner, L., Pataridis, S., Hadraba, D., Kulhavá, L., Plencner, M., Knitlová, J., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24211 · Cited by 29 · see citing works
In vivo biomarkers of structural and functional brain development and aging in humans
Franke, K., Bublak, P., Hoyer, D., Billiet, T., Christian Gaser, B., Witte, O. W., & Schwab, M. G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.002 · Cited by 28 · see citing works
Reliable Hallmarks and Biomarkers of Senescent Lymphocytes
Сергеевна, М. Ю., Tereshchenko, V., Bogdanova, D. A., & Александрович, Р. С. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115653 · Cited by 28 · see citing works
Molecular aspects of renal senescence
Schmitt, R., Susnik, N., & Melk, A. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000214 · Cited by 27 · see citing works
Telomere length and mortality in lean MAFLD: the other face of metabolic adaptation
Alarabi, M., Pan, Z., Romero‐Gómez, M., George, J., & Eslam, M. (2024) · Hepatology International · doi:10.1007/s12072-024-10701-6 · Cited by 26 · see citing works
Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia
Udomsinprasert, W., Poovorawan, Y., Chongsrisawat, V., Vejchapipat, P., Zhan, D., & Honsawek, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134689 · Cited by 25 · see citing works
Age relationships with telomere length, body weight and body length in wild dugong (Dugong dugon)
Cherdsukjai, P., Buddhachat, K., Brown, J. L., Kaewkool, M., Poommouang, A., Kaewmong, P., Kittiwattanawong, K., & Nganvongpanit, K. (2020) · PeerJ · doi:10.7717/peerj.10319 · Cited by 24 · see citing works
Kant, S., Tran, K.-V., Kvandová, M., Caliz, A. D., Yoo, H.-J., Learnard, H., Dolan, A. C., Craige, S. M., Hall, J. D., Jiménez, J. M., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317066 · Cited by 24 · see citing works
Hu, J., Lu, J., Lu, Q., Weng, W., Guan, Z., & Wang, Z. (2023) · Communications Biology · doi:10.1038/s42003-023-05397-7 · Cited by 24 · see citing works
Telomere length comparison between oral cells and blood cells among neonates
Bhattacharya, M., Bhaumik, P., & Kumar-Dey, S. (2019) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2019.04.008 · Cited by 23 · see citing works
Taking flight: An ecological, evolutionary and genomic perspective on bat telomeres
Power, M. L., Foley, N. M., Jones, G., & Teeling, E. C. (2021) · Molecular Ecology · doi:10.1111/mec.16117 · Cited by 23 · see citing works
Manoliu, A., Bosch, O. G., Brakowski, J., Brühl, A. B., & Seifritz, E. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.022 · Cited by 25 · see citing works
Telomeres are shorter and associated with number of suicide attempts in affective disorders
Birkenæs, V., Elvsåshagen, T., Westlye, L. T., Høegh, M. C., Haram, M., Werner, M. C. F., Quintana, D. S., Lunding, S. H., Martin-Ruiz, C. M., Agartz, I., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.135 · Cited by 24 · see citing works
Tick-Tock Chimes the Kidney Clock – from Biology of Renal Ageing to Clinical Applications
Rowland, J., Akbarov, A., Maan, A., Eales, J., Dormer, J., & Tomaszewski, M. (2018) · Kidney & Blood Pressure Research · doi:10.1159/000486907 · Cited by 22 · see citing works
Gu, Y., Yu, C., Miao, L., Wang, L., Xu, C., Xue, W., Du, J., Yuan, H., Dai, J., Jin, G., et al. (2016) · Scientific Reports · doi:10.1038/srep20675 · Cited by 21 · see citing works
Transcriptional profiling reveals protective mechanisms in brains of long-lived mice
Frahm, C., Srivastava, A., Schmidt, S., Mueller, J., Groth, M., Guenther, M., Ji, Y., Priebe, S., Platzer, M., & Witte, O. W. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.016 · Cited by 19 · see citing works
Towards a biological geriatric assessment
Tuttle, C. S. L., & Maier, A. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.09.017 · Cited by 18 · see citing works
Telomere length as a predictor of emotional processing in the brain
Powell, T. R., de Jong, S., Breen, G. D., Lewis, C. M., & Dima, D. (2018) · Human Brain Mapping · doi:10.1002/hbm.24487 · Cited by 17 · see citing works
Cheng, Y., Yu, C., Huang, M., Du, F., Song, C., Ma, Z., Zhai, X., Yang, Y., Liu, J., Bei, J., et al. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2017.07.011 · Cited by 16 · see citing works
Pavanello, S., Campisi, M., Rigotti, P., Bello, M. D., Nuzzolese, E., Neri, F., & Furian, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.832411 · Cited by 15 · see citing works
Resistance training enhances insulin suppression of endogenous glucose production in elderly women
Honka, M., Bucci, M., Andersson, J., Huovinen, V., Guzzardi, M. A., Sandboge, S., Savisto, N., Salonen, M. K., Badeau, R. M., Parkkola, R. K., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00950.2015 · Cited by 15 · see citing works
Telomere correlations during early life in a long-lived seabird
Schmidt, J. E., Sirman, A. E., Kittilson, J. D., Clark, M. E., Reed, W. L., & Heidinger, B. J. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.09.011 · Cited by 14 · see citing works
Ambiguities in using telomere length for age determination in two North American bat species
Ineson, K. M., O’Shea, T. J., Kilpatrick, C. W., Parise, K. L., & Foster, J. T. (2020) · Journal of Mammalogy · doi:10.1093/jmammal/gyaa064 · Cited by 14 · see citing works
Ma, Q., Cai, J., Cai, Y., Xu, Y., Chang, F., Xu, L., Zhang, G., & Guo, X. (2016) · Medicine · doi:10.1097/md.0000000000004970 · Cited by 14 · see citing works
Pańczyszyn, A., Boniewska‐Bernacka, E., & Głąb, G. (2020) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2019.11.007 · Cited by 14 · see citing works
Gellert‐Kristensen, H., Bojesen, S. E., Hansen, A. T., & Stender, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000608 · Cited by 13 · see citing works
Slykerman, R. F., Joglekar, M. V., Hardikar, A. A., Satoor, S. N., Thompson, J., Jenkins, A. J., Mitchell, E. A., & Murphy, R. (2019) · Gene · doi:10.1016/j.gene.2019.01.017 · Cited by 13 · see citing works
Telomere length in leucocytes and solid tissues of young and aged rats
Semeraro, M. D., Almer, G., Renner, W., Gruber, H., & Herrmann, M. (2022) · Aging · doi:10.18632/aging.203922 · Cited by 13 · see citing works
Wing: A suitable nonlethal tissue type for repeatable and rapid telomere length estimates in bats
Power, M. L., Power, S., Bertelsen, M. F., Jones, G., & Teeling, E. C. (2020) · Molecular Ecology Resources · doi:10.1111/1755-0998.13276 · Cited by 13 · see citing works
Validating the use of oral swabs for telomere length assessment in dogs
Dutra, L. M. L., de Souza, F. S., Friberg, I. M., Araújo, M., Vasconcellos, A. D. S., & Young, R. J. (2020) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2020.07.011 · Cited by 12 · see citing works
Minimum Reporting Recommendations for PCR-based Telomere Length MeasurementPreprint
Lindrose, A. R., & Drury, S. S. (2020) · doi:10.31219/osf.io/9pzst · Cited by 12 · see citing works
Dlouhá, D., Pitha, J. V., Mesanyova, J., Mrázková, J., Fellnerová, A., Staněk, V., Lánská, V., & Hubacek, J. A. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.12.041 · Cited by 11 · see citing works
Jasmine, F., Shinkle, J., Sabarinathan, M., Ahsan, H., Pierce, B. L., & Kibriya, M. G. (2018) · American Journal of Human Biology · doi:10.1002/ajhb.23118 · Cited by 11 · see citing works
Telomere Length in Metaphase Chromosomes of Human Triploid Zygotes
Pendina, A. A., Krapivin, M. I., Efimova, O. A., Tikhonov, A. V., Дмитриевна, М. И., Komarova, E. M., Koltsova, A. S., Gzgzyan, A. M., Kogan, I. Y., Chiryaeva, O. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115579 · Cited by 11 · see citing works
Leukocyte Telomere Length and Pancreatic Cancer Risk
Antwi, S. O., & Petersen, G. M. (2018) · Pancreas · doi:10.1097/mpa.0000000000000995 · Cited by 10 · see citing works
Mehrez, F., Bougatef, K., Monache, E. D., Arisi, I., Proietti‐De‐Santis, L., Prantera, G., Zouiten, L., Caputo, M., Elgaaïed, A. B. A., & Bongiorni, S. (2019) · Cancer Genetics · doi:10.1016/j.cancergen.2019.07.007 · Cited by 9 · see citing works
Lin, A., Arnold, B. F., Mertens, A., Lin, J., Benjamin‐Chung, J., Ali, S., Hubbard, A., Stewart, C. P., Shoab, A. K., Rahman, M. Z., et al. (2017) · eLife · doi:10.7554/elife.29365 · Cited by 9 · see citing works
Telomere Length and Risk of Incident Fracture and Arthroplasty: Findings From UK Biobank
Curtis, E. M., Codd, V., Nelson, C. P., D’Angelo, S., Wang, Q., Allara, E., Kaptoge, S. K., Matthews, P. M., Tobias, J. H., Danesh, J., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4664 · Cited by 8 · see citing works
Tarik, M., Ramakrishnan, L., Sinha, S., Sachdev, H. S., Tandon, N., Roy, A., & Bhargava, S. K. (2019) · Maternal and Child Nutrition · doi:10.1111/mcn.12857 · Cited by 7 · see citing works
Telomere length: is the future in our “ends”?
Danese, E., & Lippi, G. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.06.24 · Cited by 8 · see citing works
Age‐related telomere attrition in the human putamen
Schreglmann, S. R., Goncalves, T., Grant‐Peters, M., Kia, D. A., Soreq, L., Ryten, M., Wood, N. W., Bhatia, K. P., & Tomita, K. (2023) · Aging Cell · doi:10.1111/acel.13861 · Cited by 6 · see citing works
Is childhood stress associated with shorter telomeres?
Næss, A. B., & Kirkengen, A. L. (2015) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.14.1194 · Cited by 7 · see citing works
Airway Telomere Length in Lung Transplant Recipients
Mackintosh, J. A., Yerkovich, S. T., Tan, M. E., Samson, L. D., Hopkins, P. M.-A., & Chambers, D. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658062 · Cited by 6 · see citing works
Booth, S. A., Wadley, G. D., Marques, F. Z., Wlodek, M. E., & Charchar, F. J. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00042.2018 · Cited by 6 · see citing works
Study of Cellular Aging in a Cohort of Patients with Heart Failure
Bularca, E. A., Izarbe, M.-C. M., Olivera, S., Menao, S., Luis, S.-M. J., María, D.-M. J., & Torralba-Cabeza, M. Á. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00421-x · Cited by 6 · see citing works
Aiello, A., Accardi, G., Alì, S., Caruso, C., Chen, M., Vivo, I. D., Ligotti, M. E., Scapagnini, G., Davinelli, S., & Candore, G. (2022) · Translational Medicine UniSa · doi:10.37825/2239-9747.1026 · Cited by 5 · see citing works
Telomere dynamics in maturing frogs vary among organs
Burraco, P., Metcalfe, N. B., & Monaghan, P. (2025) · Biology Letters · doi:10.1098/rsbl.2024.0626 · Cited by 4 · see citing works
Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides
Hubacek, J. A., Pelclová, D., Dlouhá, D., Mikuška, P., DVORACKOVA, S., Vlčková, Š., Fenclová, Z., Ondráček, J., Koštejn, M., Schwarz, J., et al. (2019) · Industrial Health · doi:10.2486/indhealth.2018-0146 · Cited by 4 · see citing works
Ormerod, M. B. E. G., Ueland, T., Aas, M., Hjell, G., Rødevand, L. N., Sæther, L. S., Lunding, S. H., Johansen, I. T., Mlakar, V., Andreou, D., et al. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.62 · Cited by 5 · see citing works
Interventions Addressing the Telomere-Telomerase System
Muneer, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_26 · Cited by 3 · see citing works
Telomeres as dynamic structures of human genome: the effect of endogenous and exogenous factors
Krapivin, M. I., Sagurova, Y. M., Efimova, O. A., Tikhonov, A. V., & Pendina, A. A. (2022) · Ecological genetics · doi:10.17816/ecogen106539 · Cited by 3 · see citing works
Telomeres and Early Life Stress
Ridout, K. K., Ridout, S. J., Goonan, K., Tyrka, A. R., & Price, L. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00018-8 · Cited by 3 · see citing works
Schade, M., Sanabria, J. A., Modarresi, M., Gillon, B., Hunter, Z., Fannin, J. C., Mallick, A., Brunengraber, H., & Sanabria, J. R. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.71659 · Cited by 3 · see citing works
Dilesh, N. R., Khatri, D., Shrivastava, R., & Kushwaha, S. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70194 · Cited by 2 · see citing works
The Length of Leukocyte and Femoral Artery Telomeres in Patients with Peripheral Atherosclerosis
Boniewska‐Bernacka, E., Pańczyszyn, A., Hobot, J., Donizy, P., Ziembik, Z., Goc, A., & Klinger, M. (2022) · Genes · doi:10.3390/genes13040704 · Cited by 2 · see citing works
Casual effects of telomere length on sarcoidosis: a bidirectional Mendelian randomization analysis
Zhu, S., Hao, Z., Chen, Q., Liu, X., Wu, W., Luo, Y., & Zhang, F. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1408980 · Cited by 3 · see citing works
- Authors
- DLOUHA, D., MALUSKOVA, J., KRALOVA LESNA, I., LANSKA, V., & HUBACEK, J. A.
- Affiliations
- Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- Institute of Clinical and Experimental Medicine (CZ)
- ORCID
- HUBACEK, J. A.
- Venue
- Physiological Research
- Published
- 2014-11-15
- Volume
- 63
- Issue
- Suppl 3
- Pages
- S343-S350
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2341817121
- Cited by
- 126
- References
- 21
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 11 · 2020: 21 · 2019: 17 · 2018: 13 · 2017: 16 · 2016: 14 · 2015: 7
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- relative telomere length, telomere length, peripheral blood leukocytes, biological aging, cardiovascular aging, DNA degradation, liver, cadaveric tissue, biomarkers
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Child, Child, Preschool, DNA Damage, Female, Fetus, Humans, Infant, Infant, Newborn, Leukocytes, Mononuclear, Male, Middle Aged, Telomere, Young Adult, Telomere Shortening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
