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Cited by 293

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Acute Lung Injury – From Pathophysiology to Treatment

Open access
Mokra, D·2021·Physiological Research
DOI 10.33549/physiolres.934602
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Abstract

Acute lung injury is characterized by acute respiratory insufficiency with tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates on chest X-ray. The 1994 American-European Consensus Conference defined “acute respiratory distress syndrome, ARDS” by acute onset after a known trigger, severe hypoxemia defined by PaO2/FiO2≤200 mm Hg, bilateral infiltrates on chest X-ray, and absence of cardiogenic edema. Milder form of the syndrome with PaO2/FiO2 between 200-300 mm Hg was named „acute lung injury, ALI“. Berlin Classification in 2012 defined three categories of ARDS according to hypoxemia (mild, moderate, and severe), and the term “acute lung injury” was assigned for general description or for animal models. ALI/ARDS can originate from direct lung triggers such as pneumonia or aspiration, or from extrapulmonary reasons such as sepsis or trauma. Despite growing understanding the ARDS pathophysiology, efficacy of standard treatments, such as lung protective ventilation, prone positioning, and neuromuscular blockers, is often limited. However, there is an increasing evidence that direct and indirect forms of ARDS may differ not only in the manifestations of alterations, but also in the response to treatment. Thus, individualized treatment according to ARDS subtypes may enhance the efficacy of given treatment and improve the survival of patients.

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Metadata

Authors
Mokra, D.
Venue
Physiological Research
Publisher
Institute of Physiology of the Czech Academy of Sciences
Published
2021-01-22
Volume
69
Issue
Suppl 3
Pages
S353-S366
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
DOI
10.33549/physiolres.934602
OpenAlex
W3125587469
Cited by
293
References
91
FWCI
24.96
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Acute Lung Injury – From Pathophysiology to Treatment. https://app.cochat.ai/papers/10.33549/physiolres.934602
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Mokra, D. (2021). Acute Lung Injury – From Pathophysiology to Treatment. Physiological Research. https://doi.org/10.33549/physiolres.934602

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