The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility
Open accessAbstract
Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO 10993-4 are required prior to clinical applications. In this review, we summarize essential aspects regarding the evaluation of the hemocompatibility of biomaterials and the required in vitro analyses for determining the blood compatibility. Static, agitated, or shear flow models are used to perform hemocompatibility studies. Before and after the incubation of the test material with fresh human blood, hemolysis, cell counts, and the activation of platelets, leukocytes, coagulation and complement system are analyzed. Furthermore, the surface of biomaterials are evaluated concerning attachment of blood cells, adsorption of proteins, and generation of thrombus and fibrin networks.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Signaling in innate immunity and inflammation
Newton, K., & Dixit, V. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006049 · Cited by 1,513 · cited 2×
“Thereby, the following conformational changes on the bloodcontacting surface are considered as initial trigger for the complement activation via the alternative or classical pathway (Gorbet and Sefton, 2004; Andersson et al., 2005; Nilsson et al., 2007).”
BackgroundThe role of complement in biomaterial-induced inflammation
Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.020 · Cited by 431
Monitoring in vitro thrombus formation with novel microfluidic devices
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Hernandez, J. L., & Woodrow, K. A. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102087 · Cited by 259
Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)
Huzum, B., Puha, B., Necoara, R., Gheorghevici, S., Puha, G., Filip, A., Sirbu, P., & Alexa, O. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10750 · Cited by 253
Nájera-Maldonado, L., Parra-González, M., Peralta-Cuevas, E., Gutierrez-Onofre, A. J., Garcia-Atutxa, I., & Villanueva-Flores, F. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17091169 · Cited by 40
Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
Santonocito, D., Vivero-Lopez, M., Lauro, M. R., Torrisi, C., Castelli, F., Sarpietro, M. G., & Puglia, C. (2022) · Molecules · doi:10.3390/molecules27041328 · Cited by 32
Metadata
- Authors
- Weber, M., Steinle, H., Golombek, S., Hann, L., Schlensak, C., Wendel, H. P., & Avci-Adali, M.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2018-07-16
- Volume
- 6
- Pages
- 99-99
- ISSN
- 2296-4185 (ISSN-L)
- OpenAlex
- W2884780408
- Cited by
- 728
- References
- 5
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- Weber, M., Steinle, H., Golombek, S., Hann, L., Schlensak, C., Wendel, H. P., & Avci-Adali, M. (2018). Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2018.00099
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
