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Cited by 16Bone Tissue Engineering MaterialsDental Implant Techniques and OutcomesSurface Treatment and Coatings

Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo

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Wang, Hui, Yuan, Changyong, Lin, Kaili, Zhu, Rui, Zhang, Shilei·2021·Frontiers in Bioengineering and Biotechnology
DOI 10.3389/fbioe.2021.761911PMC PMC8678591
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Abstract

Nowadays, 3D printing technology has been applied in dentistry to fabricate customized implants. However, the biological performance is unsatisfactory. Polydopamine (PDA) has been used to immobilize bioactive agents on implant surfaces to endow them with multiple properties, such as anti-infection and pro-osteogenesis, benefiting rapid osseointegration. Herein, we fabricated a PDA coating on a 3D-printed implant surface (3D-PDA) via the in situ polymerization method. Then the 3D-PDA implants’ pro-osteogenesis capacity and the osseointegration performance were evaluated in comparison with the 3D group. The in vitro results revealed that the PDA coating modification increased the hydrophilicity of the implants, promoting the improvement of the adhesion, propagation, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. Additionally, the 3D-PDA implant improved osteointegration performance in vivo. The present study suggested that PDA coating might be a feasible strategy to optimize 3D-printed implant surfaces, making a preliminary research basis for the subsequent work to immobilize bioactive factors on the 3D-printed implant surface.

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  • In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.

    “In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [32]

    The Conclusion and Results §§3.2–3.4 report improved BMSC adhesion and osteogenic differentiation on PDA-coated Ti6Al4V implants, plus greater osseointegration after four weeks in rats. The Introduction describes PDA as a way to functionalize material surfaces. Our copy does not report bonding tests or dentin sealing, and its discussion of hydroxyapatite deposition does not establish that PDA promotes hydroxyapatite nucleation. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Wang, H., Yuan, C., Lin, K., Zhu, R., & Zhang, S.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Xuzhou Medical College (CN)
  • Tongji University (CN)
Corresponding author
  • Lin, Kaili
  • Zhu, Rui
  • Zhang, Shilei
ORCID
Venue
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Published
2021-11-30
Volume
9
Pages
761911-761911
ISSN
2296-4185 (ISSN-L)
DOI
10.3389/fbioe.2021.761911
PMC
PMC8678591
OpenAlex
W3217302099
Cited by
16
References
4
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2
FWCI
0.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (YG2021ZD12, SKLOD2021OF01, 82072396, 81871490, 19XD1434500, 21490711700, 20191819)
  • Science and Technology Commission of Shanghai Municipality (19XD1434500, 21490711700, 20191819)
  • Shanghai Jiao Tong University (YG2021ZD12, 20191819)
  • State Key Laboratory of Oral Disease (81871490, 82072396, 20191819, SKLOD2021OF01, 19XD1434500)
  • Program of Shanghai Academic Research Leader (SKLOD2021OF01, 20191819, 81871490, 19XD1434500, 82072396)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
Keywords
polydopamine coating, 3D-printed implants, Ti-6Al-4V, osseointegration, bone marrow-derived mesenchymal stem cells, osteogenic differentiation, in situ polymerization, implant surface modification, hydrophilicity, bioactive surface modification, dental implants

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