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Cited by 47Antimicrobial Peptides and ActivitiesBone Tissue Engineering MaterialsAntimicrobial agents and applications

Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications

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Hao, Zhuowen, Chen, Renxin, Chai, Chen, Wang, Yi, Chen, Tianhong, Li, Hanke, Hu, Yingkun, Feng, Qinyu +1 more·2022·Frontiers in Bioengineering and Biotechnology
DOI 10.3389/fbioe.2022.1030162PMC PMC9582762
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Abstract

Bone tissue engineering has been becoming a promising strategy for surgical bone repair, but the risk of infection during trauma repair remains a problematic health concern worldwide, especially for fracture and infection-caused bone defects. Conventional antibiotics fail to effectively prevent or treat bone infections during bone defect repair because of drug-resistance and recurrence, so novel antibacterial agents with limited resistance are highly needed for bone tissue engineering. Antimicrobial peptides (AMPs) characterized by cationic, hydrophobic and amphipathic properties show great promise to be used as next-generation antibiotics which rarely induce resistance and show potent antibacterial efficacy. In this review, four common structures of AMPs (helix-based, sheet-based, coil-based and composite) and related modifications are presented to identify AMPs and design novel analogs. Then, potential effects of AMPs for bone infection during bone repair are explored, including bactericidal activity, anti-biofilm, immunomodulation and regenerative properties. Moreover, we present distinctive applications of AMPs for topical bone repair, which can be either used by delivery system (surface immobilization, nanoparticles and hydrogels) or used in gene therapy. Finally, future prospects and ongoing challenges are discussed.

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  • Growth factor-derived peptides as adjunct therapies to PRP enhance wound healing and tendon regeneration.

    “Additionally, growth factor-derived peptides have been explored as adjunct therapies to PRP, demonstrating enhanced wound healing and tendon regeneration [101,102].”

    From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [102]

    The Introduction discusses antimicrobial peptides in wound repair, and §3.4 discusses their regenerative effects in bone tissue engineering. Neither passage addresses growth factor-derived peptides used alongside PRP or an effect on tendon regeneration. Searches for PRP, tendon, and growth factor-derived peptides found no passage establishing the attributed claim. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Hao, Z., Chen, R., Chai, C., Wang, Y., Chen, T., Li, H., Hu, Y., Feng, Q., & Li, J.
Affiliations
Zhongnan Hospital of Wuhan University (CN)
Corresponding author
Li, Jingfeng
ORCID
Venue
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Published
2022-10-06
Volume
10
Pages
1030162-1030162
ISSN
2296-4185 (ISSN-L)
DOI
10.3389/fbioe.2022.1030162
PMC
PMC9582762
OpenAlex
W4302286604
Cited by
47
References
3
Citations by year
2026: 12 · 2025: 12 · 2024: 18 · 2023: 3 · 2022: 2
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (No: 81871752)
  • Science and Technology Program of Hubei Province (No: 2022BCA052)
  • Natural Science Foundation of Hubei Province (No: 2020CFB551)
  • Zhongnan Hospital of Wuhan University (No: cxpy2019074 No. ZNJC202014)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Keywords
antimicrobial peptides, bone tissue engineering, bone infection, antibiotic resistance, bone defects, fracture healing, antibacterial peptides, peptide structure, antibiofilm activity, immunomodulation, topical drug delivery, surface immobilization, nanoparticles, hydrogels, gene therapy

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