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Cited by 57Hydrogels: synthesis, properties, applicationsElectrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applications

Natural polymer-based scaffolds for soft tissue repair

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Chen, Meiwen, Jiang, Rui, Deng, Niping, Zhao, Xiumin, Li, Xiangjuan, Guo, Chengchen·2022·Frontiers in Bioengineering and Biotechnology
DOI 10.3389/fbioe.2022.954699PMC PMC9343850
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Abstract

Soft tissues such as skin, muscle, and tendon are easily damaged due to injury from physical activity and pathological lesions. For soft tissue repair and regeneration, biomaterials are often used to build scaffolds with appropriate structures and tailored functionalities that can support cell growth and new tissue formation. Among all types of scaffolds, natural polymer-based scaffolds attract much attention due to their excellent biocompatibility and tunable mechanical properties. In this comprehensive mini-review, we summarize recent progress on natural polymer-based scaffolds for soft tissue repair, focusing on clinical translations and materials design. Furthermore, the limitations and challenges, such as unsatisfied mechanical properties and unfavorable biological responses, are discussed to advance the development of novel scaffolds for soft tissue repair and regeneration toward clinical translation.

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  • In the context of fibrotic capsule formation, scaffolds based on natural polymers seem to have better interaction with the host immune system when compared to fossil-based scaffolds.

    “In the context of fibrotic capsule formation, scaffolds based on natural polymers seem to have better interaction with the host immune system when compared to fossil-based scaffolds [218].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [218]

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Cited by

Sorted by citations

Authors
Chen, M., Jiang, R., Deng, N., Zhao, X., Li, X., & Guo, C.
Affiliations
  • Hangzhou Women’s Hospital (CN)
  • Westlake University (CN)
Corresponding author
  • Li, Xiangjuan
  • Guo, Chengchen
ORCID
Venue
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Published
2022-07-19
Volume
10
Pages
954699-954699
ISSN
2296-4185 (ISSN-L)
DOI
10.3389/fbioe.2022.954699
PMC
PMC9343850
OpenAlex
W4285798612
Cited by
57
References
0
Citations by year
2026: 15 · 2025: 16 · 2024: 17 · 2023: 9
FWCI
0.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (No. 52103129, 52103129)
  • National Health Commission of the People's Republic of China (WKJ-ZJ-2215)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
soft tissue repair, tissue regeneration, biomaterials, biocompatibility, mechanical properties, clinical translation, materials design, skin regeneration, tendon regeneration, muscle regeneration

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