Metabolic regulation by biomaterials in osteoblast
Open accessAbstract
The repair of bone defects resulting from high-energy trauma, infection, or pathological fracture remains a challenge in the field of medicine. The development of biomaterials involved in the metabolic regulation provides a promising solution to this problem and has emerged as a prominent research area in regenerative engineering. While recent research on cell metabolism has advanced our knowledge of metabolic regulation in bone regeneration, the extent to which materials affect intracellular metabolic remains unclear. This review provides a detailed discussion of the mechanisms of bone regeneration, an overview of metabolic regulation in bone regeneration in osteoblasts and biomaterials involved in the metabolic regulation for bone regeneration. Furthermore, it introduces how materials, such as promoting favorable physicochemical characteristics (e.g., bioactivity, appropriate porosity, and superior mechanical properties), incorporating external stimuli (e.g., photothermal, electrical, and magnetic stimulation), and delivering metabolic regulators (e.g., metal ions, bioactive molecules like drugs and peptides, and regulatory metabolites such as alpha ketoglutarate), can affect cell metabolism and lead to changes of cell state. Considering the growing interests in cell metabolic regulation, advanced materials have the potential to help a larger population in overcoming bone defects.
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- Authors
- Kang, Z., Wu, B., Zhang, L., Liang, X., Guo, D., Yuan, S., & Xie, D.
- Affiliations
- Third Affiliated Hospital of Southern Medical University (CN)
- Corresponding author
- Xie, Denghui
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2023-05-30
- Volume
- 11
- Pages
- 1184463-1184463
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC10265685
- OpenAlex
- W4378901184
- Cited by
- 15
- References
- 141
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81772315, 81974328)
- Natural Science Foundation of Guangdong Province
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2022B1515020044)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- bone regeneration, osteoblasts, cellular metabolism, biomaterials, bone defects, metabolic regulation, external stimuli, photothermal stimulation, electrical stimulation, magnetic stimulation, metal ions, alpha-ketoglutarate, bioactive peptides, drug delivery, porosity, bioactivity (biomaterials), mechanical properties
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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