Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise
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OCN directly promotes glucose and FFA uptake by SkM and establishes a positive feedback loop with IL-6, which results in increased glucose and FFA utilization by SkM and the release of bioactive OCN by bone.
“It directly promotes glucose and FFA uptake by SkM and establishes a positive feedback loop with IL-6, which also results in increased glucose and FFA utilization by SkM and the release of bioactive OCN by bone [71].”
IL-6 upregulates the secretion of OCN by bone, which reduces the expression of TNF-α and increases that of IL-10 and adiponectin in adipocytes.
“Additionally, it has been found to upregulate the secretion of OCN by bone [71] (2b), which reduces the expression of TNF-α and increases that of IL-10 (3a) and adiponectin in adipocytes [211] (3b).”
IL-6 increases production of OCN by osteoblasts, which itself stimulates transient pancreatic secretion of the anorexic hormone insulin and triggers a positive feed-forward mechanism that results in increased OCN and thus more insulin.
“Moreover, IL-6 increases production of OCN by osteoblasts [71] (2c), which itself stimulates transient pancreatic secretion of the anorexic hormone insulin and triggers a positive feed-forward mechanism that results in increased OCN and thus more insulin [28,209,210] (2d).”
IL-6 promotes the release of OCN.
“and to promote the release of OCN [71] (3c)”
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- Authors
- Mera, P., Laue, K., Ferron, M., Confavreux, C., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., Bacchetta, J., Szulc, P., Kitsis, R. N., de Cabo, R., Friedman, R. A., Torsitano, C., McGraw, T. E., Puchowicz, M., Kurland, I., & Karsenty, G.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 25
- Issue
- 1
- Pages
- 218
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2608325042
- Cited by
- 63
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 4 · 2013: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- osteocalcin, exercise capacity, skeletal muscle, muscle fibers, aging, glucose uptake, lipid metabolism, endurance exercise
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