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Roles of PLODs in Collagen Synthesis and Cancer Progression
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genes. Expression of PLODs is regulated by multiple cytokines, transcription factors and microRNAs. Dysregulation of PLODs promotes cancer progression and metastasis, suggesting that targeting PLODs is potential strategy for cancer treatment. Here, we summarize the recent progress in the investigation of function and regulation of PLODs in normal tissue development and disease progression, especially in cancer.
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Metadata
- Authors
- Qi, Y., & Xu, R.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Xu, Ren
- ORCID
- Xu, Ren
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-28
- Volume
- 6
- Pages
- 66-66
- ISSN
- 2296-634X (ISSN-L)
- PMC
- PMC6031748
- OpenAlex
- W2808438085
- Cited by
- 248
- References
- 87
- Citations by year
- 2026: 20 · 2025: 31 · 2024: 28 · 2023: 26 · 2022: 42 · 2021: 38 · 2020: 48 · 2019: 13 · 2018: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (1R01CA207772, 1R01CA215095, 1R21CA209045)
- U.S. Department of Defense (W81XWH-15-1-0052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- collagen synthesis, tumor progression, metastasis, gene expression regulation, cytokines, transcription factors, microRNA, histogenesis, cancer therapy targets
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