The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response
Open accessAbstract
The complicated interactions between Leishmania and the host antigen-presenting cells (APCs) have fundamental effects on the final outcome of the disease. Two major APCs, macrophages and dendritic cells (DCs), play critical roles in mediating resistance and susceptibility during Leishmania infection. Macrophages are the primary resident cell for Leishmania: they phagocytose and permit parasite proliferation. However, these cells are also the major effector cells to eliminate infection. The effective clearance of parasites by macrophages depends on activation of appropriate immune response, which is usually initiated by DCs. Here, we review the early interaction of APCs with Leishmania parasites and how these interactions profoundly impact on the ensuing adaptive immune response. We also discuss how the current knowledge will allow further refinement of our understanding of the interplay between Leishmania and its hosts that leads to resistance or susceptibility.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,336
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Seger, R., & Krebs, E. G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.9.7601337 · Cited by 3,602
Mechanisms of phagocytosis in macrophages
Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854
Takeda, K., & Akira, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.003 · Cited by 2,461
Regulation of immune responses by L-arginine metabolism
Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775
A mechanism for the initiation of allergen-induced T helper type 2 responses
Sokol, C. L., Barton, G. M., Farr, A. G., & Medzhitov, R. (2008) · Nature Immunology · doi:10.1038/ni1558 · Cited by 961
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Peters, N. C., Egen, J. G., Secundino, N., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P., Fay, M. P., Germain, R. N., & Sacks, D. (2008) · Science · doi:10.1126/science.1159194 · Cited by 834
Cited by
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
Matzaraki, V., Kumar, V., Wijmenga, C., & Zhernakova, A. (2017) · Genome biology · doi:10.1186/s13059-017-1207-1 · Cited by 566
Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania
Lima-Junior, D. S., Costa, D. L., Carregaro, V., Cunha, L. D., Silva, A. L. N., Mineo, T. W. P., Gutierrez, F. R. S., Bellio, M., Bortoluci, K. R., Flavell, R. A., et al. (2013) · Nature Medicine · doi:10.1038/nm.3221 · Cited by 360
Possibilities and challenges for developing a successful vaccine for leishmaniasis
Srivastava, S., Shankar, P., Mishra, J., & Singh, S. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1553-y · Cited by 201
Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis
Ghosh, S., Jiang, N., Farr, L., Ngobeni, R., & Moonah, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01995 · Cited by 62
Venugopal, G., Bird, J. T., Washam, C. L., Roys, H., Bowlin, A., Byrum, S. D., & Weinkopff, T. (2022) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0010518 · Cited by 26
Metadata
- Authors
- Liu, D., & Uzonna, J. E.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 2
- Pages
- 83-83
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W2043819612
- Cited by
- 364
- References
- 83
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response. https://app.cochat.ai/papers/10.3389/fcimb.2012.00083
- The paper
- Liu, D., & Uzonna, J. E. (2012). The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2012.00083
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
