The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus
Open accessAbstract
Neutrophils are the most abundant leukocytes in human blood and the first line of defense after bacteria have breached the epithelial barriers. After migration to a site of infection, neutrophils engage and expose invading microorganisms to antimicrobial peptides and proteins, as well as reactive oxygen species, as part of their bactericidal arsenal. Ideally, neutrophils ingest bacteria to prevent damage to surrounding cells and tissues, kill invading microorganisms with antimicrobial mechanisms, undergo programmed cell death to minimize inflammation, and are cleared away by macrophages. Staphylococcus aureus (S. aureus) is a prevalent Gram-positive bacterium that is a common commensal and causes a wide range of diseases from skin infections to endocarditis. Since its discovery, S. aureus has been a formidable neutrophil foe that has challenged the efficacy of this professional assassin. Indeed, proper clearance of S. aureus by neutrophils is essential to positive infection outcome, and S. aureus has developed mechanisms to evade neutrophil killing. Herein, we will review mechanisms used by S. aureus to modulate and evade neutrophil bactericidal mechanisms including priming, activation, chemotaxis, production of reactive oxygen species, and resolution of infection. We will also highlight how S. aureus uses sensory/regulatory systems to tailor production of virulence factors specifically to the triggering signal, e.g., neutrophils and defensins. To conclude, we will provide an overview of therapeutic approaches that may potentially enhance neutrophil antimicrobial functions.
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Citations
Cites
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“It is also a leading cause of infections ranging from superficial skin abscesses to life-threatening diseases, including septicemia and necrotizing pneumonia (Klevens et al., 2007; Kobayashi et al., 2015).”
BackgroundNovel cell death program leads to neutrophil extracellular traps
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Cited by
Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms
Kwiecinski, J. M., & Horswill, A. R. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.02.005 · Cited by 373
The Role of Macrophages in Staphylococcus aureus Infection
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Ulfig, A., & Leichert, L. I. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03591-y · Cited by 239
Metadata
- Authors
- Guerra, F. E., Borgogna, T. R., Patel, D. M., Sward, E. W., & Voyich, J. M.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-06-30
- Volume
- 7
- Pages
- 286-286
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W2670533836
- Cited by
- 158
- References
- 19
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guerra, F. E., Borgogna, T. R., Patel, D. M., Sward, E. W., & Voyich, J. M. (2017). Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2017.00286
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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