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PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection

Utari, Putri D., Setroikromo, Rita, Melgert, Barbro N., Quax, Wim J.·2018·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2018.00119
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Research works printed but not linked: 59

  1. Allen, 2005, Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo, J. Immunol., 174, 3643, 10.4049/jimmunol.174.6.3643 · DOI · Paper page
  2. Bayes, 2016, A murine model of early Pseudomonas aeruginosa lung disease with transition to chronic infection, Sci. Rep., 6, 35838, 10.1038/srep35838 · DOI
  3. Bivas-Benita, 2005, Non-invasive pulmonary aerosol delivery in mice by the endotracheal route, Eur. J. Pharm. Biopharm., 61, 214, 10.1016/j.ejpb.2005.04.009 · DOI · Paper page
  4. Bjarnsholt, 2005, Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections, Microbiology, 151, 3873, 10.1099/mic.0.27955-0 · DOI · Paper page
  5. Bokhove, 2010, The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket, Proc. Natl. Acad. Sci. U.S.A., 107, 686, 10.1073/pnas.0911839107 · DOI · Paper page
  6. Breidenstein, 2011, Pseudomonas aeruginosa: all roads lead to resistance, Trends Microbiol., 19, 419, 10.1016/j.tim.2011.04.005 · DOI · Paper page
  7. Cámara, 2002, Controlling infection by tuning in and turning down the volume of bacterial small-talk, Lancet Infect. Dis., 2, 667, 10.1016/S1473-3099(02)00447-4 · DOI · Paper page
  8. Colombo, 2005, Cytokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy, Pediatr. Pulmonol., 40, 15, 10.1002/ppul.20237 · DOI
  9. Dong, 2000, AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora, Proc. Natl. Acad. Sci. U.S.A., 97, 3526, 10.1073/pnas.97.7.3526 · DOI
  10. Drake, 2011, Structural characterization and high-throughput screening of inhibitors of PvdQ, an Ntn hydrolase involved in pyoverdine synthesis, ACS Chem. Biol., 6, 1277, 10.1021/cb2002973 · DOI
  11. Driscoll, 2007, The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections, Drugs, 67, 351, 10.2165/00003495-200767030-00003 · DOI · Paper page
  12. Dubin, 2007, IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice, Am. J. Physiol. Lung Cell. Mol. Physiol., 292, L519, 10.1152/ajplung.00312.2006 · DOI · Paper page
  13. Eyles, 1999, Immunological responses to nasal delivery of free and encapsulated tetanus toxoid: studies on the effect of vehicle volume, Int. J. Pharm., 189, 75, 10.1016/S0378-5173(99)00239-2 · doi:10.1016/s0378-5173(99)00239-2
  14. Fernandes, 2009, Preclinical models for pulmonary drug delivery, Expert Opin. Drug Deliv., 6, 1231, 10.1517/17425240903241788 · DOI
  15. Fetzner, 2014, Quorum quenching enzymes, J. Biotechnol., 201, 2, 10.1016/j.jbiotec.2014.09.001 · DOI · Paper page
  16. Fuqua, 2002, Listening in on bacteria: acyl-homoserine lactone signalling, Nat. Rev. Mol. Cell Biol., 3, 685, 10.1038/nrm907 · DOI · Paper page
  17. García-Contreras, 2013, Resistance to quorum-quenching compounds, Appl. Environ. Microbiol., 79, 6840, 10.1128/AEM.02378-13 · DOI
  18. Hentzer, 2003, Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J. Clin. Invest., 112, 1300, 10.1172/JCI20074 · doi:10.1172/jci20074 · Paper page
  19. Hentzer, 2002, Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound, Microbiology, 148, 87, 10.1099/00221287-148-1-87 · DOI · Paper page
  20. Hraiech, 2014, Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia, PLoS ONE, 9, e107125, 10.1371/journal.pone.0107125 · DOI
  21. Imamura, 2005, Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection, J. Med. Microbiol., 54, 515, 10.1099/jmm.0.46004-0 · doi:10.1099/jmm.0.46004-0
  22. Jakobsen, Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa, Appl. Environ. Microbiol., 78, 2410, 10.1128/AEM.05992-11 · DOI · Paper page
  23. Jakobsen, Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing, Antimicrob. Agents Chemother., 56, 2314, 10.1128/AAC.05919-11 · DOI · Paper page
  24. Jensen, 2007, Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa, Microbiology, 153, 1329, 10.1099/mic.0.2006/003863-0 · DOI · Paper page
  25. Jimenez, 2012, The multiple signaling systems regulating virulence in Pseudomonas aeruginosa, Microbiol. Mol. Biol. Rev., 76, 46, 10.1128/MMBR.05007-11 · DOI · Paper page
  26. Kalia, 2013, Quorum sensing inhibitors: an overview, Biotechnol. Adv., 31, 224, 10.1016/j.biotechadv.2012.10.004 · DOI · Paper page
  27. Karlsson, 2012, N-Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling, J. Leukoc. Biol., 91, 15, 10.1189/jlb.0111034 · DOI
  28. Karpati, 2000, TNF-α and IL-8 in consecutive sputum samples from cystic fibrosis patients during antibiotic treatment, Scand. J. Infect. Dis., 32, 75, 10.1080/00365540050164263 · doi:10.1080/00365540050164263
  29. Koch, 2014, Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase, FEMS Microbiol. Lett., 356, 62, 10.1111/1574-6968.12479 · doi:10.1111/1574-6968.12479
  30. Kukavica-Ibrulj, 2014, Assessing Pseudomonas aeruginosa virulence and the host response using murine models of acute and chronic lung infection, Methods Mol. Biol., 1149, 757, 10.1007/978-1-4939-0473-0_58 · DOI
  31. LaSarre, 2013, Exploiting quorum sensing to confuse bacterial pathogens, Microbiol. Mol. Biol. Rev., 77, 73, 10.1128/MMBR.00046-12 · DOI · Paper page
  32. Maylyala, 2008, Endotoxin limits in formulations for preclinical research, J. Pharm. Sci., 97, 2041, 10.1002/jps.21152 · DOI · Paper page
  33. Migiyama, 2013, Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia, Antimicrob. Agents Chemother., 57, 3653, 10.1128/AAC.00456-13 · DOI
  34. Munder, 2014, Assessing Pseudomonas virulence using mammalian models: acute infection model, Methods Mol. Biol., 1149, 773, 10.1007/978-1-4939-0473-0_59 · DOI
  35. Papaioannou, 2009, Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model, Antimicrob. Agents Chemother., 53, 4891, 10.1128/AAC.00380-09 · DOI
  36. Papenfort, 2016, Quorum sensing signal-response systems in Gram-negative bacteria, Nat. Rev. Microbiol., 14, 576, 10.1038/nrmicro.2016.89 · DOI · Paper page
  37. Passador, 1993, Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication, Science, 260, 1127, 10.1126/science.8493556 · DOI · Paper page
  38. Puel, 2010, Biosynthesis and toxicological effects of patulin, Toxins, 2, 613, 10.3390/toxins2040613 · DOI · Paper page
  39. Rasmussen, 2005, Identity and effects of quorum-sensing inhibitors produced by Penicillium species, Microbiology, 151, 1325, 10.1099/mic.0.27715-0 · DOI · Paper page
  40. Richman-Eisenstat, 1996, Cytokine soup: making sense of inflammation in cystic fibrosis, Pediatr. Pulmonol., 21, 3, 10.1002/1099-0496(199601)21:1<3::AID-PPUL1950210103>3.0.CO;2-B · doi:10.1002/1099-0496(199601)21:1<3::aid-ppul1950210103>3.0.co;2-b
  41. Ruehl-Fehlert, 2004, Revised guides for organ sampling and trimming in rats and mice–Part 2. A joint publication of the RITA* and NACAD** groups, Exp. Toxic Pathol., 55, 91, 10.1078/0940-2993-00311 · DOI · Paper page
  42. Sio, 2006, Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1, Infect. Immun., 74, 1673, 10.1128/IAI.74.3.1673-1682.2006 · DOI · Paper page
  43. Southam, 2002, Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia, Am. J. Physiol. Lung Cell. Mol. Physiol., 282, L833, 10.1152/ajplung.00173.2001 · DOI · Paper page
  44. Tateda, 2003, The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils, Infect. Immun., 71, 5785, 10.1128/IAI.71.10.5785-5793.2003 · DOI · Paper page
  45. Telford, 1998, The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunodulatory activity, Inf. Immun., 66, 36, 10.1128/IAI.66.1.36-42.1998 · DOI · Paper page
  46. Thomas, 2006, Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages, Mol. Biosyst., 2, 132, 10.1039/B517248A · DOI
  47. Tonnis, 2014, A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals, Eur. J. Pharm. Biopharm., 88, 1056, 10.1016/j.ejpb.2014.10.011 · doi:10.1016/j.ejpb.2014.10.011
  48. Uroz, 2005, N-acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities, Microbiology, 151, 3313, 10.1099/mic.0.27961-0 · DOI
  49. Van Delden, 1998, Cell-to-cell signaling and Pseudomonas aeruginosa infections, Emerging Infect. Dis., 4, 551, 10.3201/eid0404.980405 · DOI · Paper page
  50. van Heeckeren, 2002, Murine models of chronic Pseudomonas aeruginosa lung infection, Lab. Anim., 36, 291, 10.1258/002367702320162405 · doi:10.1258/002367702320162405
  51. Wahjudi, 2012, Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections, Eur. J. Pharm. Sci., 48, 637, 10.1016/j.ejps.2012.12.015 · doi:10.1016/j.ejps.2012.12.015
  52. Wahjudi, 2011, PA0305 of Pseudomonas aeruginosa is a quorum quenching acylhomoserine lactone acylase belonging to the Ntn hydrolase superfamily, Microbiology, 157, 2042, 10.1099/mic.0.043935-0 · doi:10.1099/mic.0.043935-0
  53. Wang, 2010, AiiM, a novel class ot N-acylhomosenne lactonase from the leaf-associated bacterium Microbacterium testaceum, Appl. Environ. Microbiol., 76, 2524, 10.1128/AEM.02738-09 · DOI
  54. Whiteley, 1999, Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. U.S.A., 96, 13904, 10.1073/pnas.96.24.13904 · DOI · Paper page
  55. Winson, 1998, Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing, FEMS Microbiol. Lett., 163, 185, 10.1111/j.1574-6968.1998.tb13044.x · doi:10.1111/j.1574-6968.1998.tb13044.x
  56. Wölbeling, 2011, Lung function and inflammation during murine Pseudomonas aeruginosa airway infection, Immunobiology, 216, 901, 10.1016/j.imbio.2011.02.003 · DOI
  57. Wölbeling, 2010, Head-out spirometry accurately monitors the course of Pseudomonas aeruginosa lung infection in mice, Respiration, 80, 340, 10.1159/000319442 · DOI
  58. Wu, 2001, Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection, Microbiology, 147, 1105, 10.1099/00221287-147-5-1105 · DOI · Paper page
  59. Wu, 2004, Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, J. Antimicrob. Chemother., 53, 1054, 10.1093/jac/dkh223 · DOI · Paper page

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Metadata

Authors
Utari, P. D., Setroikromo, R., Melgert, B. N., & Quax, W. J.
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2018-04-26
Volume
8
ISSN
2235-2988
DOI
10.3389/fcimb.2018.00119
Cited by
79
References
0
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection. https://app.cochat.ai/papers/10.3389/fcimb.2018.00119
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Utari, P. D., Setroikromo, R., Melgert, B. N., & Quax, W. J. (2018). PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2018.00119

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