The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Angiopoietin-Like Proteins: A Comprehensive Look
Open accessAbstract
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“which codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity [93–95]”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [94]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Like angiopoietin proteins, ANGPTL proteins, with the exception of ANGPTL8, contain a coiled-coil domain and a large globular C-terminal fibrinogen-like domain (12, 13).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The family currently has eight known members, ANGPTL1-8, with pleiotropic functions (13).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
In the citing paper
“Each of the ANGPTL proteins contain a signal peptide and can be secreted from cells.”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation
Yi, P., Park, J.-S., & Melton, D. A. (2013) · Cell · doi:10.1016/j.cell.2013.04.008 · Cited by 449
Retracted(1996) · Institutional Research Information System University of Turin (University of Turin) · doi:10.1111/j · Cited by 5,486
Colman (2022) · doi:10.1073/pnas · Cited by 4,370
Drug delivery with carbon nanotubes for in vivo cancer treatment
Liu, Z., Chen, K., Davis, C. R., Sherlock, S. P., Cao, Q., Chen, X. S., & Dai, H. (2008) · PubMed · doi:10.48550/arxiv.0808.2070 · Cited by 2,287
Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia
Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002926 · Cited by 754
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433
Atypical angiopoietin-like protein that regulates ANGPTL3
Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C., & Hobbs, H. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217552109 · Cited by 409
Angptl3 regulates lipid metabolism in mice
Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., & Furukawa, H. (2002) · Nature Genetics · doi:10.1038/ng814 · Cited by 379
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
Zhang, C. C., Kaba, M., Ge, G., Xie, K. T., Tong, W., Hug, C., & Lodish, H. F. (2006) · Nature Medicine · doi:10.1038/nm1342 · Cited by 372
Tabata, M., Kadomatsu, T., Fukuhara, S., Miyata, K., Ito, Y., Endo, M., Urano, T., Zhu, H. J., Tsukano, H., Tazume, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.003 · Cited by 367
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–320 of 320
Ke, J., He, Z., Duan, Y., Zhu, Y., Xu, Y., Zhou, H., Lei, J., Wang, H., Shan, Z., Zhang, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4552153/v1
Fox Pathway’inin Kanser Üzerine Etkisi
Kosova, F., & Umur, N. (2024) · Bingöl Üniversitesi Sağlık Dergisi · doi:10.58605/bingolsaglik.1491979 · Cited by 1
Shannon, M. J., & Beristain, A. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.16.628789
Cheng, C., Wang, C., Zhu, W., Su, C., Dong, Y., Teng, J., Fu, K., Zhai, C., Qiao, L., & Chen, W. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1559267 · Cited by 1
Cao, Y., Xu, Y., Chen, C., Xie, H., Lu, H., & Hu, J. (2021) · Figshare · doi:10.6084/m9.figshare.13544243
Sun, T., Zhan, W., Wei, L., Xu, Z., Fan, L., Zhuo, Y., Wang, C., & Zhang, J. (2021) · Figshare · doi:10.6084/m9.figshare.16944500
Saccone, M. A. (2019) · theses.fr (ABES) · doi:10.70675/d8995276z6866z4372zbbc2z271914e8a438
Santulli, G., Pande, S., & Varzideh, F. (2026) · Journal of Molecular Medicine · doi:10.1007/s00109-026-02682-w
Self-citationMajchrowicz, G., Jońca, M., Kurys, N., Piekarska, W., & Litke, S. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5095
Griffin, K. V., Hocevar, S. E., Schwartz, S. R., Smiley, B. M., Ross, B. C., Athukorala, K. S., Saunders, M. N., Anderson, A. J., Cummings, B. J., & Shea, L. D. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2177-25.2026
Bai, J., Gao, Q., Liu, Y., Gao, M., & Zhou, Y. (2026) · The FASEB Journal · doi:10.1096/fj.202504150rr
(192647), J. P., Junjiang, J., Junnan, Z., Zhou, S., Tingyan, H., Xuyu, C., Qinghua, P., & Yasha, Z. (2026) · Digital Chinese Medicine · doi:10.1016/j.dcmed.2026.05.011
Urinary ANGPTL3: a novel noninvasive biomarker for podocyte injury in pediatric glomerular diseases
Wang, H., Liu, J.-L., Dai, R., Wang, C., Chen, X., Wang, X., Jialu, L., Tang, X. S., Han, X. L., Zhai, Y., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08512-4
Bararu‐Bojan, I., Vladeanu, M. C., Iliescu-Halițchi, D., Pleșoianu, C. E., Bojan, A., Frăsinariu, O. E., Tudor, R. C., Ciocoiu, M., Tudor, C., Haliţchi, C. I., et al. (2026) · Diagnostics · doi:10.3390/diagnostics16152313
Reduced Circulating Angiopoietin‐Like Protein Levels in Crimean‐Congo Hemorrhagic Fever
Yeşildağ, S. K., Büyüktuna, S. A., Öksüz, C., & Doğan, H. O. (2026) · Apmis · doi:10.1111/apm.70246
Zhang, W., Dai, S., Fan, H., Nian, Y., Xu, L., Liu, Z., Min, Y., Jiang, Z., Zhou, L., Yang, H., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108392
Foia, L. G., Goriuc, A., Luchian, I. A., Budală, D. G., Toma, V., Bogdán, M., Minea, B., & Ghemiș, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177917
Jahromi, M., Gheith, O. A. A., Othman, N. F., Jahrami, K., & Tuomilehto, J. O. (2026) · Research Square · doi:10.21203/rs.3.rs-11258285/v1
Vámos, S., Beine, K., Vozza, I., Gillmor, R., Feugere, L., Li, J., & Valero, K. C. W. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7666090
Metadata
- Authors
- Santulli, G.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Santulli, Gaetano
- ORCID
- Santulli, Gaetano
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 4-4
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC3899539
- OpenAlex
- W2133904925
- Cited by
- 320
- References
- 92
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 40 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 37 · 2016: 21 · 2015: 15 · 2014: 7
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- angiopoietin-like proteins, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, ANGPTL7, ANGPTL8, angiopoietins, lipid metabolism, glucose metabolism, inflammation, hematopoiesis, cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
