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Angiopoietin-Like Proteins: A Comprehensive Look
Open accessAbstract
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.
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“which codes for a glycoprotein with roles in angiogenesis, tissue remodeling, inflammation, and inhibition of lipoprotein lipase (LPL) catalytic activity [93–95]”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [94]
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“Like angiopoietin proteins, ANGPTL proteins, with the exception of ANGPTL8, contain a coiled-coil domain and a large globular C-terminal fibrinogen-like domain (12, 13).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
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“The family currently has eight known members, ANGPTL1-8, with pleiotropic functions (13).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
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“Each of the ANGPTL proteins contain a signal peptide and can be secreted from cells.”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [13]
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Metadata
- Authors
- Santulli, G.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Santulli, Gaetano
- ORCID
- Santulli, Gaetano
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 4-4
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC3899539
- OpenAlex
- W2133904925
- Cited by
- 320
- References
- 92
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 40 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 37 · 2016: 21 · 2015: 15 · 2014: 7
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- angiopoietin-like proteins, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, ANGPTL7, ANGPTL8, angiopoietins, lipid metabolism, glucose metabolism, inflammation, hematopoiesis, cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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