Cited by 320Lipid metabolism and disordersAngiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

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Angiopoietin-Like Proteins: A Comprehensive Look

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Santulli, Gaetano·2014·Frontiers in Endocrinology

DOI 10.3389/fendo.2014.00004PMC PMC3899539

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Abstract

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.

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Authors: Santulli, G.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Santulli, Gaetano
ORCID: Santulli, Gaetano
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2014
Volume: 5
Pages: 4-4
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2014.00004
PMC: PMC3899539
OpenAlex: W2133904925
Cited by: 320
References: 92
Citations by year: 2026: 15 · 2025: 25 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 40 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 37 · 2016: 21 · 2015: 15 · 2014: 7
FWCI: 4.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: angiopoietin-like proteins, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, ANGPTL7, ANGPTL8, angiopoietins, lipid metabolism, glucose metabolism, inflammation, hematopoiesis, cancer

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Angiopoietin-Like Proteins: A Comprehensive Look

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