The DOI matches its Crossref record; 198 of the 199 references it cites were found in a registry or an index.
Epigenetic Programming and Fetal Metabolic Programming
Open accessAbstract
Fetal metabolic programming caused by the adverse intrauterine environment can induce metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal long-term relatively irreversible changes in organs and metabolism, and thus causes fetal metabolic programming leading metabolic syndrome in adult offspring. Fetal metabolic programming of obesity and insulin resistance plays a key role in this process. The mechanism of fetal metabolic programming is still not very clear. It is suggested that epigenetic programming, also induced by the adverse intrauterine environment, is a critical underlying mechanism of fetal metabolic programming. Fetal epigenetic programming affects gene expression changes and cellular function through epigenetic modifications without DNA nucleotide sequence changes. Epigenetic modifications can be relatively stably retained and transmitted through mitosis and generations, and thereby induce the development of metabolic syndrome in adult offspring. This manuscript provides an overview of the critical role of epigenetic programming in fetal metabolic programming.
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“Such changes may also modify placental nutrient transport, promote compensatory nutrient delivery and predispose offspring to metabolic disorders later in life [18,173,174].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [18]
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2 retracted
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RetractedWarne, J. P., Alemi, F., Reed, A. S., Varonin, J. M., Chan, H., Piper, M. L., Mullin, M. E., Myers, M. G., Corvera, C. U., & Xu, A. W. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.008 · Cited by 3
RetractedEffect of In Utero and Early-Life Conditions on Adult Health and Disease
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Persistent epigenetic differences associated with prenatal exposure to famine in humans
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Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,463
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765
Obesity in Young Men after Famine Exposure in Utero and Early Infancy
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Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508347112 · Cited by 751
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655
DNA methylation signatures link prenatal famine exposure to growth and metabolism
Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms6592 · Cited by 630
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Metadata
- Authors
- Zhu, Z., Cao, F., & Li, X.
- Affiliations
- Soochow University (CN)
- Nanjing Medical University (CN)
- Corresponding author
- Li, Xiaozhong
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-12-03
- Volume
- 10
- Pages
- 764-764
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6901800
- OpenAlex
- W2981958174
- Cited by
- 158
- References
- 199
- Citations by year
- 2026: 27 · 2025: 24 · 2024: 24 · 2023: 23 · 2022: 21 · 2021: 22 · 2020: 17
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Jiangsu Commission of Health
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetic programming, metabolic syndrome, adult offspring, obesity, insulin resistance, epigenetic modifications, transgenerational epigenetic inheritance, fetal development
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