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Cited by 24Mesenchymal stem cell researchBone Tissue Engineering MaterialsMedicinal Plant Pharmacodynamics Research

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Epigenetic control of mesenchymal stem cells orchestrates bone regeneration

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Wang, Xiaofeng, Yu, Fanyuan, Ye, Ling·2023·Frontiers in Endocrinology
DOI 10.3389/fendo.2023.1126787PMC PMC10025550
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Abstract

Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-healing bone regeneration processes and biomaterial-induced healing of bone defects beyond the critical size, MSCs show several functions, including osteogenic differentiation and thus providing seed cells. However, adverse factors such as drug intake and body senescence can significantly affect the functions of MSCs in bone regeneration. Currently, several modalities have been developed to regulate MSCs’ phenotype and promote the bone regeneration process. Epigenetic regulation has received much attention because of its heritable nature. Indeed, epigenetic regulation of MSCs is involved in the pathogenesis of a variety of disorders of bone metabolism. Moreover, studies using epigenetic regulation to treat diseases are also being reported. At the same time, the effects of epigenetic regulation on MSCs are yet to be fully understood. This review focuses on recent advances in the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs. We intend to illustrate how epigenetic regulation of MSCs orchestrates the process of bone regeneration.

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Figure 1 Disease with bone dyshomeostasis associated with epigenetic alterations. Multiple diseases, drugs, or body senescence will lead the skeletal system to bone dyshomeostasis. Among these situations, changes in epigenetic regulation affect the osteogenic differentiation of MSCs and mediate the loss of bone homeostasis and impairment of bone regeneration.
Figure 1 Disease with bone dyshomeostasis associated with epigenetic alterations. Multiple diseases, drugs, or body senescence will lead the skeletal system to bone dyshomeostasis. Among these situations, changes in epigenetic regulation affect the osteogenic differentiation of MSCs and mediate the loss of bone homeostasis and impairment of bone regeneration.CC BY · PubMed Central
Figure 2 Epigenetic control of MSCs osteogenic differentiation in bone regeneration. Epigenetic regulation, represented by histone modification and DNA methylation, has an impact on MSCs osteogenic differentiation. Epigenetic regulation affects bone regeneration by influencing the lineage commitment of MSCs. The green font represents promoters of osteogenic differentiation and the red font represents inhibitors of osteogenic differentiation.
Figure 2 Epigenetic control of MSCs osteogenic differentiation in bone regeneration. Epigenetic regulation, represented by histone modification and DNA methylation, has an impact on MSCs osteogenic differentiation. Epigenetic regulation affects bone regeneration by influencing the lineage commitment of MSCs. The green font represents promoters of osteogenic differentiation and the red font represents inhibitors of osteogenic differentiation.CC BY · PubMed Central

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Metadata

Authors
Wang, X., Yu, F., & Ye, L.
Affiliations
Sichuan University (CN)
Corresponding author
  • Yu, Fanyuan
  • Ye, Ling
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2023-03-06
Volume
14
Pages
1126787-1126787
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2023.1126787
PMC
PMC10025550
OpenAlex
W4323315627
Cited by
24
References
1
Citations by year
2026: 3 · 2025: 7 · 2024: 10 · 2023: 4
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (2022QNRC001, U21A20368, 82201045)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
Keywords
mesenchymal stem cells, epigenetic regulation, bone regeneration, osteogenic differentiation, cellular senescence, stem cell proliferation, bone defects, critical-size bone defect, metabolic bone disease, epigenetic therapy
MeSH terms
Bone Regeneration, Cell Differentiation, Osteogenesis, Epigenesis, Genetic, Mesenchymal Stem Cells

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