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Thermodynamic Control of Small RNA-Mediated Gene Silencing

Ui-Tei, Kumiko, Nishi, Kenji, Takahashi, Tomoko, Nagasawa, Tatsuya·2012·Frontiers in Genetics
DOI 10.3389/fgene.2012.00101PMC PMC3366367
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  • Modifications that modify the ribose sugar group or substitution modifications to the 2' hydroxyl group of the ribose can affect TS of the siRNA duplex and influence strand selection.

    “Additional modifications that modify the ribose sugar group or substitution modifications to the 2′ hydroxyl group of the ribose can also affect TS of the siRNA duplex and influence strand selection.”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Ui-Tei et al., 2012

  • Chemical modifications that affect the 5' end stability of the siRNA duplex can affect the relative TS of each end and lead to a reversal in siRNA strand selection.

    “In particular, chemical modifications that affect the 5′ end stability of the siRNA duplex can affect the relative TS of each end and lead to a reversal in siRNA strand selection (Bramsen et al., 2009; Bramsen & Kjems, 2013; Ui‐Tei, Nishi, Takahashi, & Nagasawa, 2012).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Ui-Tei, Nishi, Takahashi, & Nagasawa, 2012

  • Modifications to the 3' overhangs can directly affect TS and can influence strand selection.

    “Further, modifications to the 3′ overhangs can also directly affect TS and can influence strand selection (Bramsen et al., 2009; Bramsen & Kjems, 2013; Ui‐Tei et al., 2012).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Ui-Tei et al., 2012

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Research works printed but not linked: 40

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Authors
Ui-Tei, K., Nishi, K., Takahashi, T., & Nagasawa, T.
Venue
Frontiers in Genetics
Publisher
Frontiers Media SA
Published
2012
Volume
3
ISSN
1664-8021
DOI
10.3389/fgene.2012.00101
PMC
PMC3366367
Cited by
29
References
0

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