The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation
Open accessAbstract
The discovery of microRNAs (miRNAs) has led to a paradigm shift in our basic understanding of gene regulation. Competing endogenous RNAs (ceRNAs) are the recent entrants adding to the complexities of miRNA mediated gene regulation. ceRNAs are RNAs that share miRNA recognition elements (MREs) thereby regulating each other. It is apparent that miRNAs act as rheostats that fine-tune gene expression and maintain the functional balance of various gene networks. Thus MREs in coding and non-coding transcripts have evolved to become the crosstalk hubs of gene interactions, affecting the expression levels and activities of different ceRNAs. Decoding the crosstalk between MREs mediated by ceRNAs is critical to delineate the intricacies in gene regulation, and we have just begun to unravel this complexity.
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Cited by
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
Endogenous microRNA sponges: evidence and controversy
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microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease
Thomas, K. T., Gross, C., & Bassell, G. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00455 · Cited by 64
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Zhang, X., Wen, L., Chen, S., Zhang, J., Ma, Y., Hu, J., Yue, T., Wang, J., Zhu, J., Bu, D., et al. (2020) · Cancer Cell International · doi:10.1186/s12935-020-1155-9 · Cited by 35
Metadata
- Authors
- Kartha, R. V., & Subramanian, S.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 8-8
- ISSN
- 1664-8021 (ISSN-L)
- OpenAlex
- W1965347187
- Cited by
- 402
- References
- 15
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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