Cited by 311Alzheimer's disease research and treatmentsGenetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

The DOI matches its Crossref record; 320 of the 322 references it cites were found in a registry or an index, and 1 are not checked yet.

Use of Caenorhabditis elegans as a model to study Alzheimerâ€™s disease and other neurodegenerative diseases

Open access

Alexander, Adanna G., Marfil, Vanessa, Li, Chris·2014·Frontiers in Genetics

DOI 10.3389/fgene.2014.00279PMC PMC4155875

Open this paper in CoChat — free account Open PDF

Abstract

Advances in research and technology has increased our quality of life, allowed us to combat diseases, and achieve increased longevity. Unfortunately, increased longevity is accompanied by a rise in the incidences of age-related diseases such as Alzheimer's disease (AD). AD is the sixth leading cause of death, and one of the leading causes of dementia amongst the aged population in the USA. It is a progressive neurodegenerative disorder, characterized by the prevalence of extracellular Aβ plaques and intracellular neurofibrillary tangles, derived from the proteolysis of the amyloid precursor protein (APP) and the hyperphosphorylation of microtubule-associated protein tau, respectively. Despite years of extensive research, the molecular mechanisms that underlie the pathology of AD remain unclear. Model organisms, such as the nematode, Caenorhabditis elegans, present a complementary approach to addressing these questions. C. elegans has many advantages as a model system to study AD and other neurodegenerative diseases. Like their mammalian counterparts, they have complex biochemical pathways, most of which are conserved. Genes in which mutations are correlated with AD have counterparts in C. elegans, including an APP-related gene, apl-1, a tau homolog, ptl-1, and presenilin homologs, such as sel-12 and hop-1. Since the neuronal connectivity in C. elegans has already been established, C. elegans is also advantageous in modeling learning and memory impairments seen during AD. This article addresses the insights C. elegans provide in studying AD and other neurodegenerative diseases. Additionally, we explore the advantages and drawbacks associated with using this model.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fgene.2014.00279

Cites

320 of 321 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–321 of 321

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
Li, X., & Greenwald, I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12204 · Cited by 165
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Guénette, S. Y., Chen, J., Jondro, P. D., & Tanzi, R. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10832 · Cited by 158
ALSOD: The Amyotrophic Lateral Sclerosis Online Database
Wroe, R., Butler, A. W., Andersen, P. M., Powell, J. F., & Al‐Chalabi, A. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960802146106 · Cited by 158
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans
Kuwahara, T., Koyama, A., Koyama, S., Yoshina, S., Ren, C.-H., Kato, T., Mitani, S., & Iwatsubo, T. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn198 · Cited by 158
Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein
Fonte, V. G., Kipp, D. R., Yerg, J., Merin, D. A., Forrestal, M., Wagner, E., Roberts, C. M., & Link, C. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703339200 · Cited by 157
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
Link, C. D., Johnson, C. J., Fonte, V. G., Paupard, M., Hall, D. H., Styren, S. D., Mathis, C. A., & Klunk, W. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00237-2 · Cited by 157
Expression of αB-crystallin in Alzheimer's disease
Renkawek, K., Voorter, C., Bosman, G. C. G. M., van Workum, F. V., & de Jong, W. D. (1994) · Acta Neuropathologica · doi:10.1007/bf00296185 · Cited by 157
Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.
L’Hernault, S. W., & Arduengo, P. M. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.1.55 · Cited by 155
A gp330/megalin-related protein is required in the major epidermis ofCaenorhabditis elegansfor completion of molting
Yochem, J., Tuck, S., Greenwald, I., & Han, M. (1999) · Development · doi:10.1242/dev.126.3.597 · Cited by 155
Differential Contributions ofCaenorhabditis elegansHistone Deacetylases to Huntingtin Polyglutamine Toxicity
Bates, E. A., Victor, M., Jones, A. K., Shi, Y., & Hart, A. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3344-05.2006 · Cited by 149
APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability
Hornsten, A., Lieberthal, J. G., Fadia, S., Malins, R., Ha, L., Xu, X., Daigle, I., Markowitz, M. K., O'Connor, G., Plasterk, R. H. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603997104 · Cited by 146
Self-citation
A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
Brandt, R., Gergou, A., Wacker, I. U., Fath, T., & Hutter, H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.011 · Cited by 146
Autophagy Genes Protect Against Disease Caused by Polyglutamine Expansion Proteins inCaenorhabditis elegans
Jia, K., Hart, A. C., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.3528 · Cited by 145
Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins
Zambrano, N., Buxbaum, J. D., Minopoli, G., Fiore, F., de Candia, P., Renzis, S. D., Faraonio, R., Sabo, S. L., Cheetham, J., Sudol, M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6399 · Cited by 143
nhr-25, the Caenorhabditis elegans Ortholog of ftz-f1, Is Required for Epidermal and Somatic Gonad Development
Gissendanner, C. R., & Sluder, A. E. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9679 · Cited by 140
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
Liu, Z., Hamamichi, S., Lee, B. D., Yang, D., Ray, A., Caldwell, G. A., Caldwell, K. A., Dawson, T. M., Smith, W. W., & Dawson, V. L. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr312 · Cited by 139
Non-neuronal 210×103Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau
Chapin, S. J., & Bulinski, J. C. (1991) · Journal of Cell Science · doi:10.1242/jcs.98.1.27 · Cited by 138
Deranged Expression of Molecular Chaperones in Brains of Patients with Alzheimer's Disease
Yoo, B. C., Kim, S. H., Cairns, N. J., Fountoulakis, M., & Lübec, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4109 · Cited by 137
Croup: Pathogenesis and management
Goldhagen, J. L. (1983) · Journal of Emergency Medicine · doi:10.1016/0736-4679(83)90003-3 · Cited by 134
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38δ at Thr50 promotes microtubule assembly
Feijoo, C., Campbell, D. G., Jakes, R., Goedert, M., & Cuenda, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.01655 · Cited by 133
Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease
Perez, N., Sugar, J., Charya, S., Johnson, G. S., Merril, C. R., Bierer, L. M., Perl, D. P., Haroutunian, V. H., & Wallace, W. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90033-t · Cited by 132
The Caenorhabditis elegans Aβ1–42 Model of Alzheimer Disease Predominantly Expresses Aβ3–42
McColl, G., Roberts, B. R., Gunn, A. P., Perez, K. A., Tew, D. J., Masters, C. L., Barnham, K. J., Cherny, R. A., & Bush, A. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.028514 · Cited by 131
ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism
Murakami, T., Yang, S., Xie, L., Kawano, T., Fu, D., Mukai, A., Böhm, C., Chen, F., Robertson, J., Suzuki, H., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr417 · Cited by 131
Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components
Zhang, Y., Luo, W.-J., Wang, H., Lin, P. P., Vetrivel, K. S., Liao, F., Li, F., Wong, P. C., Farquhar, M. G., Thinakaran, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409467200 · Cited by 128
Isolation and Partial Characterization of Neurofibrillary Tangles and Amyloid Plaque Core in Alzheimerʼs Disease
Gorevic, P. D., Goñi, F., Pons‐Estel, B. A., Álvarez, F., Peress, N. S., & Frangione, B. (1986) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198611000-00004 · Cited by 124
PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans
Goedert, M., Baur, C.-P., Ahringer, J., Jakes, R., Hasegawa, M., Spillantini, M. G., Smith, M. J., & Hill, F. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.11.2661 · Cited by 123
Molecular cloning of a ubiquitously distributed microtubule-associated protein with Mr 190,000.
Aizawa, H., Emori, Y., Murofushi, H., Kawasaki, H., Sakai, H., & Suzuki, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77426-7 · Cited by 122
Frontotemporal Lobar Degeneration
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-44781-2.50191-1 · Cited by 120
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
Goutte, C., Hepler, W., Mickey, K. M., & Priess, J. R. (2000) · Development · doi:10.1242/dev.127.11.2481 · Cited by 119
Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity
Faber, P. W., Voisine, C., King, D. C., Bates, E. A., & Hart, A. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262544899 · Cited by 116
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
Guthrie, C. R., Schellenberg, G. D., & Kraemer, B. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp099 · Cited by 116
Progressive neurodegeneration in C. elegans model of tauopathy
Miyasaka, T., Ding, Z., Gengyo-Ando, K., Oue, M., Yamaguchi, H., Mitani, S., & Ihara, Y. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.017 · Cited by 115 · cited 2×
“Several transgenic lines expressing human tau harboring FTD17 mutations (htau-FTD-17) have been generated in C. elegans (Figure 4B) (see also Section “PTL-1 as a Tau Model”; Kraemer et al., 2003; Miyasaka et al., 2005; Brandt et al., 2009; Fatouros et al., 2012).”
Background
First Symptoms – Frontotemporal Dementia versus Alzheimer’s Disease
Lindau, M., Almkvist, O., Kushi, J., Boone, K., Johansson, S. H., Wahlund, L., Cummings, J. L., & Miller, B. L. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017251 · Cited by 115
Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)
Knauer, M. F., Orlando, R. A., & Glabe, C. G. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00711-1 · Cited by 115
A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.
Yochem, J., & Greenwald, I. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4572 · Cited by 113
Juvenile Huntington disease
van Dijk, J. G., van der Velde, E. A., Roos, R. A. C., & Bruyn, G. W. (1986) · Human Genetics · doi:10.1007/bf00401235 · Cited by 113
A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress
Springer, W., Hoppe, T., Schmidt, E., & Baumeister, R. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi371 · Cited by 113
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels
Simón, A., Schiapparelli, L., Colocho, P. E. S., Cuadrado‐Tejedor, M., Escribano, L., de Maturana, R. L., Río, J. D., Pérez‐Mediavilla, A., & Frechilla, D. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.005 · Cited by 112
Absence of Disease Phenotype and Intergenerational Stability of the Cag Repeat in Transgenic Mice Expressing the Human Huntington Disease Transcript
Goldberg, Y. P., Kalchman, M. A., Metzler, M., Nasir, J., Zeisler, J., Graham, R. K., Koide, H., OʼKusky, J. R., Sharp, A. H., Ross, C. A., et al. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.2.177 · Cited by 112
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor protein
Russo, T., Faraonio, R., Minopoli, G., de Candia, P., Renzis, S. D., & Zambrano, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00941-7 · Cited by 111
Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies
Malek, A. M., Barchowsky, A., Bowser, R. P., Youk, A. O., & Talbott, E. O. (2012) · Environmental Research · doi:10.1016/j.envres.2012.06.007 · Cited by 110
Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
Vaccaro, A., Patten, S. A., Ciura, S., Maios, C., Therrien, M., Drapeau, P., Kabashi, E., & Parker, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042117 · Cited by 107
The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans
Asahina, M., Ishihara, T., Jindra, M., Kohara, Y., Katsura, I., & Hirose, S. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00361.x · Cited by 107
The Oogenic Germline Starvation Response in C. elegans
Seidel, H. S., & Kimble, J. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028074 · Cited by 106
Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
Cam (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-8 · Cited by 106
Mutations that prevent associative learning in C. elegans.
Wen, J. Y. M., Kumar, N., Morrison, G. E., Rambaldini, G., Runciman, S., Rousseau, J., & van der Kooy, D. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.2.354 · Cited by 103
Biogenesis of secretory granules
Borgonovo, B., Ouwendijk, J., & Solimena, M. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.06.010 · Cited by 100
Risk of Chronic Low-Dose Selenium Overexposure in Humans: Insights From Epidemiology and Biochemistry
Vinceti, M., Maraldi, T., Bergomi, M., & Malagoli, C. (2009) · Reviews on Environmental Health · doi:10.1515/reveh.2009.24.3.231 · Cited by 99
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25
Hayes, G. D., Frand, A. R., & Ruvkun, G. (2006) · Development · doi:10.1242/dev.02655 · Cited by 99
HANDBUCH DER NEUROLOGIE
Bumk, E., & Foerste, R. (1939) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193908000-00006 · Cited by 99
The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis
Arduengo, P. M., Appleberry, O. K., Chuang, P., & L’Hernault, S. W. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.24.3645 · Cited by 97
UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
Sumakovic, M., Hegermann, J., Luo, L., Husson, S. J., Schwarze, K., Olendrowitz, C., Schoofs, L., Richmond, J., & Eimer, S. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902096 · Cited by 97
TheCaenorhabditis elegansJIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein
Arimoto, M., Koushika, S. P., Choudhary, B. C., Li, C., Matsumoto, K., & Hisamoto, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2653-10.2011 · Cited by 95
Self-citation
The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell
Newman, A. P., White, J. G., & Sternberg, P. W. (1995) · Development · doi:10.1242/dev.121.2.263 · Cited by 94
A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan
Lee, B. H., & Ashrafi, K. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000213 · Cited by 94
Polarized secretion of beta-amyloid precursor proteinand amyloid beta-peptide in MDCK cells.
Haass, C., Koo, E. H., Teplow, D. B., & Selkoe, D. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1564 · Cited by 94
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans
Niwa, R., Zhou, F. L., Li, C., & Slack, F. J. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.044 · Cited by 94
Self-citation
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's β-amyloid precursor protein
Duilio, A., Faraonio, R., Minopoli, G., Zambrano, N., & Russo, T. (1998) · Biochemical Journal · doi:10.1042/bj3300513 · Cited by 93
A genetic model for age at onset in Huntington disease.
Farrer, L. A., & Conneally, P. M. (1985) · PubMed · Cited by 91
Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis
Thinakaran, G., Kitt, C., Roskams, A. J., Slunt, H., Masliah, E., von Koch, C., Ginsberg, S. D., Ronnett, G. V., Reed, R. R., & Price, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06314.1995 · Cited by 90
Insulin Signaling Plays a Dual Role in Caenorhabditis elegans Memory Acquisition and Memory Retrieval
Lin, C. H. A., Tomioka, M., Pereira, S., Sellings, L. H. L., Iino, Y., & van der Kooy, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4636-09.2010 · Cited by 90
Microtubule-associated proteins from cultured HeLa cells. Analysis of molecular properties and effects on microtubule polymerization.
Bulinski, J. C., & Borisy, G. G. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70328-7 · Cited by 89
Endonuclease G mediates α‐synuclein cytotoxicity during Parkinson's disease
Büttner, S., Habernig, L., Broeskamp, F., Ruli, D., Vögtle, F. N., Vlachos, M., Macchi, F., Küttner, V., Carmona‐Gutierrez, D., Eisenberg, T., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.228 · Cited by 87
A genetic screen inCaenorhabditis elegansfor dopamine neuron insensitivity to 6‐hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking
Nass, R., Hahn, M. K., Jessen, T. N., McDonald, P. W., Carvelli, L., & Blakely, R. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03205.x · Cited by 83
Genetic testing of children at risk for Huntington's disease
NANCE, M. A., & US Huntington Disease Genetic Testing Group (1997) · Neurology · doi:10.1212/wnl.49.4.1048 · Cited by 83
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
Edwards, S. L., Charlie, N. K., Richmond, J. E., Hegermann, J., Eimer, S., & Miller, K. G. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902095 · Cited by 83
Mutations that prevent associative learning in C. elegans.
Wen, J. Y. M., Kumar, N., Morrison, G. E., et al. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.2.354 · Cited by 83
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel- 12 and hop- 1 in Notch-pathway signaling
Westlund, B., Parry, D., Clover, R., Basson, M., & Johnson, C. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2497 · Cited by 82
Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin.
Nielsen, R., Birn, H., Moestrup, S. K., Nielsen, M. S., Verroust, P. J., & Christensen, E. I. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v9101767 · Cited by 81
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.
Sandbrink, R., Masters, C. L., & Beyreuther, K. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36778-9 · Cited by 79
TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
Vaccaro, A., Tauffenberger, A., Ash, P. E. A., Carlomagno, Y., Petrucelli, L., & Parker, J. A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002806 · Cited by 79
Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)
Zheng, G., Marinò, M., Zhao, J., & McCluskey, R. T. (1998) · Endocrinology · doi:10.1210/endo.139.3.5978 · Cited by 79
Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans
Estevez, A. O., Mueller, C. L., Morgan, K. L., Szewczyk, N. J., Teece, L., Miranda‐Vizuete, A., & Estevez, M. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.04.019 · Cited by 78
ptl-1, aCaenorhabditis elegansGene Whose Products Are Homologous to the τ Microtubule-Associated Proteins,
McDermott, J. B., Aamodt, S., & Aamodt, E. J. (1996) · Biochemistry · doi:10.1021/bi952646n · Cited by 78
Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation
Witan, H., Kern, A., Koziollek‐Drechsler, I., Wade, R. C., Behl, C., & Clement, A. M. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn025 · Cited by 78
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deák, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Röder, H., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds431 · Cited by 78
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease
Ruan, Q., Harrington, A. J., Caldwell, K. A., Caldwell, G. A., & Standaert, D. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.011 · Cited by 77
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease
Locke, C. J., Fox, S. A., Caldwell, G. A., & Caldwell, K. A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.003 · Cited by 77
Identification of gene expression changes in transgenic C. elegans overexpressing human α-synuclein
Vartiainen, S., Pehkonen, P., Lakso, M., Nass, R., & Wong, G. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.021 · Cited by 76
SUT-1 enables tau-induced neurotoxicity in C . elegans
Kraemer, B. C., & Schellenberg, G. D. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm143 · Cited by 76
The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
Caylor, R. C., Jin, Y., & Ackley, B. D. (2013) · Neural Development · doi:10.1186/1749-8104-8-10 · Cited by 74
Control of body size in C. elegans dependent on food and insulin/IGF-1 signal
So, S., Miyahara, K., & Ohshima, Y. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01514.x · Cited by 73
ALZHEIMER'S PRESENILE DEMENTIA. A HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY.
Mr, K., Rg, F., & Bensch, K. G. (1965) · PubMed · Cited by 73
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans
Mangahas, P. M., Yu, X., Miller, K. G., & Zhou, Z. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708130 · Cited by 72
The ultrastructure of senile plaques.
Luse, S. A., & Smith, K. R. (1964) · PubMed Central · Cited by 66
MSUT2 is a determinant of susceptibility to tau neurotoxicity
Guthrie, C. R., Greenup, L., Leverenz, J. B., & Kraemer, B. C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr079 · Cited by 64
Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons
Lejeune, F., Mesrob, L., Parmentier, F., Bicep, C., Vázquez‐Manrique, R. P., Parker, J. A., Vert, J., Tourette, C., & Néri, C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-91 · Cited by 64
Huntington's disease: CAG genetics expands neurobiology
Gusella, J. F., & MacDonald, M. E. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80072-7 · Cited by 63
Low Density Lipoprotein Receptor-Related Protein-2 Expression in Efferent Duct and Epididymal Epithelia: Evidence in Rats for its in Vivo Role in Endocytosis of Apolipoprotein J/Clusterin1
Morales, C. R., Igdoura, S. A., Wosu, U., Boman, J. M., & Argraves, W. S. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.3.676 · Cited by 61
Juvenile Huntington disease in the Netherlands
Siesling, S., der Vlis, M. V.-V., & Roos, R. A. C. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(97)00069-6 · Cited by 59
Protein with tau-like repeats regulates neuronal integrity and lifespan inC. elegans
Chew, Y. L., Fan, X., Götz, J., & Nicholas, H. (2013) · Journal of Cell Science · doi:10.1242/jcs.jcs124404 · Cited by 59
Genetic screen for small body size mutants in C. elegans reveals many TGFβ pathway components
Savage‐Dunn, C., Maduzia, L. L., Zimmerman, C. M., Roberts, A. F., Cohen, S., Tokarz, R., & Padgett, R. W. (2003) · genesis · doi:10.1002/gene.10184 · Cited by 59
Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases
Muñoz-Lobato, F., Rodríguez‐Palero, M. J., Naranjo-Galindo, F. J., Shephard, F., Gaffney, C. J., Szewczyk, N. J., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., Link, C. D., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5051 · Cited by 57
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE
Jarriault, S., & Greenwald, I. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.014 · Cited by 57
Interaction between β‐amyloid and lens αB‐crystallin
Liang, J. J. ‐. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02136-0 · Cited by 55
Intracellular Trafficking and Synaptic Function of APL-1 in Caenorhabditis elegans
Wiese, M., Antebi, A., & Zheng, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012790 · Cited by 55
parkin mutation analysis in clinic patients with early‐onset Parkinson's disease
Poorkaj, P., Nutt, J. G., James, D., Gancher, S., Bird, T. D., Steinbart, E. J., Schellenberg, G. D., & Payami, H. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30157 · Cited by 55
Identification of neuroprotective compounds of Caenorhabditis elegans dopaminergic neurons against 6-OHDA
Marvanová, M., & Nichols, C. D. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn/31:02:127 · Cited by 51
VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans
Han, S. M., Oussini, H. E., Scekic‐Zahirovic, J., Vibbert, J., Cottee, P. A., PRASAIN, J. K., Bellen, H. J., Dupuis, L., & Miller, M. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003738 · Cited by 51
Ultrastructural localization of megalin in the rat cochlear duct
Mizuta, K., Saito, A., Watanabe, T., Nagura, M., Arakawa, M., Shimizu, F., & Hoshino, T. (1999) · Hearing Research · doi:10.1016/s0378-5955(98)00221-4 · Cited by 51
feh-1 and apl-1, the Caenorhabditis elegansorthologues of mammalian Fe65 and β-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping
Zambrano, N., Bimonte, M., Arbucci, S., Gianni, D., Russo, T., & Bazzicalupo, P. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1411 · Cited by 47
The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans
Estevez, A. O., Morgan, K. L., Szewczyk, N. J., Gems, D., & Estevez, M. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2013.12.012 · Cited by 47
Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans
Boccitto, M., Lamitina, T., & Kalb, R. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033494 · Cited by 46
Large C9orf72 repeat expansions are not a common cause of Parkinson's disease
Majounie, E., Abramzon, Y. A., Renton, A. E., Keller, M. F., Traynor, B. J., & Singleton, A. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.007 · Cited by 45
The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans
Gordon, P., Hingula, L. P., Krasny, M. L., Swienckowski, J. L., Pokrywka, N. J., & Raley‐Susman, K. M. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0250-z · Cited by 43
Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
Cao, P., Yuan, Y., Pehek, E. A., Moise, A. R., Huang, Y., Palczewski, K., & Feng, Z. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009312 · Cited by 40
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan
Dumas, K. J., Guo, C., Wang, X., Burkhart, K. B., Adams, E. J., Alam, H., & Hu, P. J. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.02.022 · Cited by 38
A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
Bieschke, J., Cohen, E., Murray, A. N., Dillin, A. G., & Kelly, J. W. (2009) · Protein Science · doi:10.1002/pro.234 · Cited by 34
Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid β Protein Production via the β-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling
Yoon, I., Pietrzik, C. U., Kang, D. E., & Koo, E. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413729200 · Cited by 33
APL-1, the Alzheimer’s Amyloid Precursor Protein inCaenorhabditis elegans, Modulates Multiple Metabolic Pathways Throughout Development
Ewald, C. Y., Raps, D. A., & Li, C. (2012) · Genetics · doi:10.1534/genetics.112.138768 · Cited by 33
Self-citation
Two suppressors ofsel-12encode C2H2zinc-finger proteins that regulate presenilin transcription inCaenorhabditis elegans
Lakowski, B., Eimer, S., Göbel, C., Böttcher, A., Wagler, B., & Baumeister, R. (2003) · Development · doi:10.1242/dev.00429 · Cited by 32
Expression and regulation of LRP-2/megalin in epithelial cells lining the efferent ducts and epididymis during postnatal development
Hermo, L., Lustig, M., Lefrançois, S., Argraves, W. S., & Morales, C. R. (1999) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199907)53:3 · Cited by 32
Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model
Shi, Z., Lu, Z., Zhao, Y., Wang, Y., Zhao-Wilson, X., Guan, P., Duan, X., Chang, Y., & Zhao, B. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.03.001 · Cited by 30
Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration
Li, J., Li, T., Zhang, X., Tang, Y., Yang, J., & Le, W. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.003 · Cited by 29
Pan-Neuronal Expression of APL-1, an APP-Related Protein, Disrupts Olfactory, Gustatory, and Touch Plasticity in Caenorhabditis elegans
Ewald, C. Y., Cheng, R., Tolen, L., Shah, V., Gillani, A., Nasrin, A., & Li, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0495-12.2012 · Cited by 28
Self-citation
Neurodegeneration und Neuroprotektion
Schmidt, K. –. (2004) · Der Ophthalmologe · doi:10.1007/s00347-004-1104-3 · Cited by 24
Telling the difference between frontotemporal dementia and Alzheimer's disease
Pasquier, F. (2005) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000185988.05741.2a · Cited by 21
The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?
Wheeler, J. M., Guthrie, C. R., & Kraemer, B. C. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380973 · Cited by 14
Regulation of Neuronal APL-1 Expression by Cholesterol Starvation
Wiese, M., Antebi, A., & Zheng, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032038 · Cited by 8
Huntington's Disease Pathogenesis
Spada, A. R. L., Weydt, P., & Pineda, V. V. (2010) · Frontiers in neuroscience · doi:10.1201/ebk0849390005-c2 · Cited by 6
Identification of a Spatio-Temporal Enhancer Element for the Alzheimer’sAmyloid Precursor Protein-Like-1Gene in the NematodeCaenorhabditis elegans
Niwa, R., & Hada, K. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100450 · Cited by 5

Flagged first, then by citations

1 of the 322 references couldn’t be matched to a known paper.

Sorted by citations

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870
Alzheimer's disease: experimental models and reality
Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810
The C. elegans model in toxicity testing
Hunt, P. R. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3357 · Cited by 613
Phase separation and neurodegenerative diseases: a disturbance in the force
Zbinden, A., Pérez-Berlanga, M., De Rossi, P., & Polymenidou, M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.014 · Cited by 500
The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials
Pohl, F., & Lin, P. K. T. (2018) · Molecules · doi:10.3390/molecules23123283 · Cited by 284

See all 311

Authors: Alexander, A. G., Marfil, V., & Li, C.
Affiliations: The Graduate Center, CUNY (US)
City College of New York (US)
Corresponding author: Li, Chris
ORCID: Marfil, Vanessa
Li, Chris
Venue: Frontiers in Genetics
Publisher: Frontiers Media SA
Published: 2014-09-05
Volume: 5
Pages: 279-279
ISSN: 1664-8021 (ISSN-L)
DOI: 10.3389/fgene.2014.00279
PMC: PMC4155875
OpenAlex: W1983814182
Cited by: 310
References: 322
Citations by year: 2026: 13 · 2025: 19 · 2024: 38 · 2023: 42 · 2022: 40 · 2021: 35 · 2020: 39 · 2019: 19 · 2018: 23 · 2017: 14 · 2016: 20 · 2015: 6 · 2014: 1
FWCI: 9.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Genetics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
CUNY Academic Works (City University of New York) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Science Foundation
National Institutes of Health
National Institute on Aging (R01AG032042)
National Institute of General Medical Sciences (R25GM056833)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: Alzheimer's disease, Caenorhabditis elegans, neurodegenerative diseases, amyloid plaques, neurofibrillary tangles, amyloid precursor protein, tau hyperphosphorylation, presenilin, learning and memory impairment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Use of Caenorhabditis elegans as a model to study Alzheimerâ€™s disease and other neurodegenerative diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks