Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · cited 2×

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

Berg, J. (1998) · Science · doi:10.1126/science.282.5396.2012 · Cited by 4,458

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

Sulston, J. E., & Horvitz, H. R. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90158-0 · Cited by 3,479

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737

Huntington's disease

Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,691

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., et al. (2008) · Science · doi:10.1126/science.1154584 · Cited by 2,630

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

Neuropathological Classification of Huntingtonʼs Disease

VONSATTEL, J.-P., MYERS, R. H., STEVENS, T. J., FERRANTE, R. J., BIRD, E. D., & RICHARDSON, E. P. (1985) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-198511000-00003 · Cited by 2,227

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics · doi:10.1038/77060 · Cited by 2,024 · cited 1×

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935

Endonuclease G is an apoptotic DNase when released from mitochondria

Li, L. Y., Luo, X., & Wang, X. (2001) · Nature · doi:10.1038/35083620 · Cited by 1,787

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603

The distribution of tau in the mammalian central nervous system.

Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Conway, K. A., Lee, S., Rochet, J., Ding, T. T., Williamson, R. E., & Lansbury, P. T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.571 · Cited by 1,559

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

Kabashi, E., Valdmanis, P. N., Dion, P., Spiegelman, D., McConkey, B. J., Velde, C. V., Bouchard, J.-P., Lacomblez, L., Pochigaeva, K., Salachas, F., et al. (2008) · Nature Genetics · doi:10.1038/ng.132 · Cited by 1,544

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501

Trinucleotide Repeat Disorders

Orr, H. T., & Zoghbi, H. Y. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113042 · Cited by 1,394

Tau is a candidate gene for chromosome 17 frontotemporal dementia

Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374

What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study

Hughes, A. J., Ben-Shlomo, Y., Daniel, S. E., & Lees, A. J. (1992) · Neurology · doi:10.1212/wnl.42.6.1142 · Cited by 1,313

Odorant-selective genes and neurons mediate olfaction in C. elegans

Bargmann, C. I., Hartwieg, E. A., & Horvitz, H. R. (1993) · Cell · doi:10.1016/0092-8674(93)80053-h · Cited by 1,234

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., et al. (1991) · Nature · doi:10.1038/353844a0 · Cited by 1,214

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Murrell, J. R., Farlow, M. R., Ghetti, B. F., & Benson, M. D. (1991) · Science · doi:10.1126/science.1925564 · Cited by 1,142

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

Goedert, M., Wischik, C. M., Crowther, R. A., Walker, J. E., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4051 · Cited by 1,134

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,122

Single-copy insertion of transgenes in Caenorhabditis elegans

Frøkjær‐Jensen, C., Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, S., Grunnet, M., & Jørgensen, E. M. (2008) · Nature Genetics · doi:10.1038/ng.248 · Cited by 1,120

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107

The neural circuit for touch sensitivity in Caenorhabditis elegans

Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093

Notch signaling is essential for vascular morphogenesis in micePreprint

Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,065

Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Lin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Thinakaran, G., Borchelt, D., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G. J., Ratovitski, T., Davenport, F., Nordstedt, C., Seeger, M., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80291-3 · Cited by 1,025

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80244-5 · Cited by 959

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

Henderson, S. T., & Johnson, T. E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00594-2 · Cited by 949

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Yu, G., Nishimura, M., Arawaka, S., Levitan, D. J., Zhang, L., Tandon, A., Song, Y., Rogaeva, E. A., Chen, F., Kawarai, T., et al. (2000) · Nature · doi:10.1038/35024009 · Cited by 929

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., & Selkoe, D. J. (1992) · Nature · doi:10.1038/357500a0 · Cited by 919

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

Lindwall, G., & Cole, R. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42989-9 · Cited by 901

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891

Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

Alonso, A. D. C., Grundke-Iqbal, I., & Iqbal, K. (1996) · Nature Medicine · doi:10.1038/nm0796-783 · Cited by 859

Opposing activities protect against age-onset proteotoxicity

Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., & Dillin, A. (2006) · Science · doi:10.1126/science.1124646 · Cited by 843

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

Alonso, A. D. C., Zaidi, T., Novak, M., Grundke-Iqbal, I., & Iqbal, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121119298 · Cited by 827

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00189-2 · Cited by 805

Altered microtubule organization in small-calibre axons of mice lacking tau protein

Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T., & Hirokawa, N. (1994) · Nature · doi:10.1038/369488a0 · Cited by 802

Heterochronic Mutants of the Nematode Caenorhabditis elegans

Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

Biernat, J., Gustke, N., Drewes, G., Mandelkow, E., & Mandelkow, E. (1993) · Neuron · doi:10.1016/0896-6273(93)90279-z · Cited by 796

COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS

Valentine, J. S., Doucette, P. A., & Potter, S. Z. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161647 · Cited by 790

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

Conway, K. A., Harper, J. D., & Lansbury, P. T. (2000) · Biochemistry · doi:10.1021/bi991447r · Cited by 786

REST and stress resistance in ageing and Alzheimer’s disease

Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T.-H., Kim, H., Drake, D., Liu, X., et al. (2014) · Nature · doi:10.1038/nature13163 · Cited by 784

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., & Selkoe, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1037392100 · Cited by 763

Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones

Morley, J. F., & Morimoto, R. I. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0532 · Cited by 741

Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans

Bargmann, C. I., & Horvitz, H. R. (1991) · Neuron · doi:10.1016/0896-6273(91)90276-6 · Cited by 740

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

Van Deerlin, V. M., Leverenz, J. B., Bekris, L. M., Bird, T. D., Yuan, W., Elman, L. B., Clay, D., Wood, E. M., Chen-Plotkin, A. S., Martinez-Lage, M., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70071-1 · Cited by 723

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

Gems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., Larsen, P. L., & Riddle, D. L. (1998) · Genetics · doi:10.1093/genetics/150.1.129 · Cited by 718

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factorPreprint

Paradis, S., & Ruvkun, G. (1998) · Genes & Development · doi:10.1101/gad.12.16.2488 · Cited by 710

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

Levitan, D. J., & Greenwald, I. (1995) · Nature · doi:10.1038/377351a0 · Cited by 702

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

Link, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9368 · Cited by 701

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.018 · Cited by 672

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

Terry, R. D., Gonatas, N. K., & WEISS, M. (1964) · PubMed Central · Cited by 644

TDP‐43 A315T mutation in familial motor neuron disease

Gitcho, M. A., Baloh, R. H., Chakraverty, S., Mayo, K., Norton, J. B., Levitch, D., Hatanpaa, K. J., White, C. L., Bigio, E. H., Caselli, R. J., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21344 · Cited by 633

Clinical diagnosis and management of amyotrophic lateral sclerosis

Hardiman, O. M., van den Berg, L. H., & Kiernan, M. C. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.153 · Cited by 618

The lin-12 locus specifies cell fates in caenorhabditis elegans

Greenwald, I., Sternberg, P. W., & Horvitz, H. R. (1983) · Cell · doi:10.1016/0092-8674(83)90377-x · Cited by 610

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

Chen, J., Kanai, Y., Cowan, N. J., & Hirokawa, N. (1992) · Nature · doi:10.1038/360674a0 · Cited by 601

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600

Interplay of LRRK2 with chaperone-mediated autophagy

Orenstein, S. J., Kuo, S.-H., Tasset, I., Arias, E., Koga, H., Fernandez-Carasa, I., Cortes, E., Honig, L. S., Dauer, W., Consiglio, A., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3350 · Cited by 588

Genes that regulate both development and longevity in Caenorhabditis elegans.

Larsen, P. L., Albert, P. S., & Riddle, D. L. (1995) · Genetics · doi:10.1093/genetics/139.4.1567 · Cited by 584

Microtubule-Associated Proteins

Olmsted, J. B. (1986) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.02.110186.002225 · Cited by 563

Dosage‐sensitive requirement for mouse Dll4 in artery development

Duarte, A., Hirashima, M., Benedito, R., Trindade, A., Diniz, P., Bekman, E., Costa, L., Henrique, D., & Rossant, J. (2004) · Genes & Development · doi:10.1101/gad.1239004 · Cited by 563

Huntingtons Disease

Flier, J. S., Underhill, L. H., Martin, J. B., & Gusella, J. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152006 · Cited by 549

Mutations that lead to reiterations in the cell lineages of C. elegans.

Chalfie, M., Horvitz, H., & Sulston, J. (1981) · Cell · doi:10.1016/0092-8674(81)90501-8 · Cited by 541

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsPreprint

Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 540

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Hsiao, K., Borchelt, D., Olson, K., Johannsdottir, R., Kitt, C. A., Yunis, W. S., Xu, S., Eckman, C., Younkin, S. G., Price, D., et al. (1995) · Neuron · doi:10.1016/0896-6273(95)90107-8 · Cited by 527

Frontotemporal Lobar Degeneration

Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 518

Interacting genes in nematode dauer larva formation

Riddle, D. L., Swanson, M. M., & Albert, P. S. (1981) · Nature · doi:10.1038/290668a0 · Cited by 518

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Parker, J. A., Arango-Lievano, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., & Néri, C. (2005) · Nature Genetics · doi:10.1038/ng1534 · Cited by 518

OrthoList: A Compendium of C. elegans Genes with Human Orthologs

Shaye, D. D., & Greenwald, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020085 · Cited by 507

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

Lee, R., Hench, J., & Ruvkun, G. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00595-4 · Cited by 499

LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

Herz, J., Clouthier, D. E., & Hammer, R. E. (1992) · Cell · doi:10.1016/0092-8674(92)90511-a · Cited by 497

Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

Heber, S., Herms, J. W., Gajic, V., Hainfellner, J. A., Aguzzi, A., Rülicke, T., Kretzschmar, H. A., von Koch, C., Sisodia, S. S., Tremml, P., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07951.2000 · Cited by 495

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

Gasparini, L., Gouras, G. K., Wang, R., Gross, R. S., Beal, M. F., Greengard, P., & Xu, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02561.2001 · Cited by 492

Locus‐specific mutation databases for neurodegenerative brain diseases

Cruts, M., Theuns, J., & Broeckhoven, C. V. (2012) · Human Mutation · doi:10.1002/humu.22117 · Cited by 490

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

Martindale, D., Hackam, A. S., Wieczorek, A. S., Ellerby, L., Wellington, C. L., McCutcheon, K. M., Singaraja, R. R., Kazemi‐Esfarjani, P., Devon, R. M., Kim, S. U., et al. (1998) · Nature Genetics · doi:10.1038/ng0298-150 · Cited by 486

Defective forebrain development in mice lacking gp330/megalin.

Willnow, T. E., Hilpert, J., Armstrong, S. A., Rohlmann, A., Hammer, R. E., Burns, D. K., & Herz, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8460 · Cited by 484

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

Lewis, S. A., Wang, D. H., & Cowan, N. J. (1988) · Science · doi:10.1126/science.3142041 · Cited by 483

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Farg, M. A., Sundaramoorthy, V., Sultana, J. M., Yang, S., Atkinson, R. A. K., Levina, V., Halloran, M. A., Gleeson, P. A., Blair, I. P., Soo, K. Y., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu068 · Cited by 478

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

Sastre, M., Steiner, H., Fuchs, K. P., Capell, A., Multhaup, G., Condron, M. M., Teplow, D. B., & Haass, C. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve180 · Cited by 472

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

Billingsley, M. L., & Kincaid, R. L. (1997) · Biochemical Journal · doi:10.1042/bj3230577 · Cited by 466

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

KIDD, M. (1964) · Brain · doi:10.1093/brain/87.2.307 · Cited by 462

Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease

Selkoe, D. J., Abraham, C. R., Podlisny, M. B., & Duffy, L. K. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb08501.x · Cited by 452

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

Alonso, A. D. C., Grundke-Iqbal, I., Barra, H. S., & Iqbal, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.298 · Cited by 437

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000027 · Cited by 437

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansPreprint

Paradis, S., Ailion, M., Toker, A., Thomas, J. H., & Ruvkun, G. (1999) · Genes & Development · doi:10.1101/gad.13.11.1438 · Cited by 431

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4229 · Cited by 430

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

Nass, R., Hall, D. H., Miller, D. M., & Blakely, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042497999 · Cited by 423

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Strong, T. V., Tagle, D. A., Valdes, J. M., Elmer, L. W., Boehm, K., Swaroop, M., Kaatz, K. W., Collins, F. S., & Albin, R. L. (1993) · Nature Genetics · doi:10.1038/ng1193-259 · Cited by 417

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16

McElwee, J., Bubb, K., & Thomas, J. H. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00043.x · Cited by 416

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

Goutte, C., Tsunozaki, M., Hale, V. A., & Priess, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022523499 · Cited by 413

Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance

McElwee, J. J., Schuster, E. F., Blanc, E., Thomas, J. H., & Gems, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406207200 · Cited by 411

Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans.

Chalfie, M., & Sulston, J. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90459-0 · Cited by 411

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Wasco, W., Gurubhagavatula, S., Paradis, M. D., Romano, D., Sisodia, S. S., Hyman, B. T., Neve, R. L., & Tanzi, R. E. (1993) · Nature Genetics · doi:10.1038/ng0993-95 · Cited by 404

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α‐synuclein

Lakso, M., Vartiainen, S., Moilanen, A., Sirviö, J., Thomas, J. H., Nass, R., Blakely, R., & Wong, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01809.x · Cited by 403

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., & Strickland, D. K. (1995) · Cell · doi:10.1016/0092-8674(95)90320-8 · Cited by 401

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

Wasco, W., Bupp, K., Magendantz, M., Gusella, J. F., Tanzi, R. E., & Solomon, F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10758 · Cited by 399

A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span

Gerisch, B., Weitzel, C., Kober-Eisermann, C., Rottiers, V., & Antebi, A. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00085-5 · Cited by 397

Identification of the major multiphosphorylation site in mammalian neurofilaments.

Lee, V. M., Otvos, L., Carden, M. J., Hollósi, M., Dietzschold, B., & Lazzarini, R. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.6.1998 · Cited by 395

The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

Ring, S., Weyer, S. W., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M. A., Herms, J., Buchholz, C., Eckman, C. B., Korte, M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1026-07.2007 · Cited by 390

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., et al. (2011) · Science · doi:10.1126/science.1213210 · Cited by 379

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

Kraemer, B. C., Zhang, B., Leverenz, J. B., Thomas, J. H., Trojanowski, J. Q., & Schellenberg, G. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533448100 · Cited by 379

Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans

Colbert, H. A., & Bargmann, C. I. (1995) · Neuron · doi:10.1016/0896-6273(95)90224-4 · Cited by 377

TDP ‐ 43 mutation in familial amyotrophic lateral sclerosis

Yokoseki, A., Shiga, A., Tan, C., Tagawa, A., Kaneko, H., Koyama, A., Eguchi, H., Tsujino, A., Ikeuchi, T., Kakita, A., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21392 · Cited by 373

A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing

Weidemann, A., Eggert, S., Reinhard, F. B. M., Vogel, M., Paliga, K., Baier, G., Masters, C. L., Beyreuther, K. T., & Evin, G. M. (2002) · Biochemistry · doi:10.1021/bi015794o · Cited by 362

High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.

Matus, A. I., Bernhardt, R. R., & Hugh-Jones, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3010 · Cited by 358

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

Levitan, D. J., Doyle, T. G., Brousseau, D., Lee, M. K., Thinakaran, G., Slunt, H. H., Sisodia, S. S., & Greenwald, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14940 · Cited by 357

Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.

Vowels, J. J., & Thomas, J. H. (1992) · Genetics · doi:10.1093/genetics/130.1.105 · Cited by 354

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits

Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., & Morgan, D. (1999) · Behavior Genetics · doi:10.1023/a:1021691918517 · Cited by 353

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

Slunt, H. H., Thinakaran, G., von Koch, C., Lo, A., Tanzi, R. E., & Sisodia, S. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41992-2 · Cited by 346

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

Herms, J. W., Anliker, B., Heber, S., Ring, S., Fuhrmann, M., Kretzschmar, H. A., Sisodia, S. S., & Müller, U. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600390 · Cited by 343

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

Dragunow, M., Faull, R. L. M., Lawlor, P. A., Beilharz, E. J., Singleton, K., Walker, E. B., & Mee, E. T. (1995) · Neuroreport · doi:10.1097/00001756-199505090-00026 · Cited by 342

Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

von Koch, C. S., Zheng, H., Chen, H., Trumbauer, M. E., Thinakaran, G., der Ploeg, L. H. T. V., Price, D. L., & Sisodia, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00151-6 · Cited by 336

Understanding the molecular causes of Parkinson's disease

Wood‐Kaczmar, A., Gandhi, S., & Wood, N. W. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.09.007 · Cited by 334

α‐Synuclein and Parkinson's disease

Recchia, A., Debetto, P., Negro, A., Guidolin, D., Skaper, S. D., & Giusti, P. (2004) · The FASEB Journal · doi:10.1096/fj.03-0338rev · Cited by 331

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

Haass, C., Hung, A. Y., Selkoe, D. J., & Teplow, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32503-6 · Cited by 319

The Insulin/PI 3-Kinase Pathway Regulates Salt Chemotaxis Learning in Caenorhabditis elegans

Tomioka, M., Adachi, T., Suzuki, H., Kunitomo, H., Schafer, W. R., & Iino, Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.024 · Cited by 309

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

Faber, P. W., Alter, J. R., MacDonald, M. E., & Hart, A. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.179 · Cited by 306

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

Willnow, T. E., Sheng, Z., Ishibashi, S., & Herz, J. (1994) · Science · doi:10.1126/science.7515194 · Cited by 301

Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

Spillantini, M. G., Crowther, R. A., Kamphorst, W., Heutink, P., & Swieten, J. C. V. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65721-5 · Cited by 293

Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch

Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K., & Ihara, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100357200 · Cited by 292

Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2

Wang, P., Yang, G., Mosier, D. R., Chang, P., Zaidi, T., Gong, Y.-D., Zhao, N.-M., Dominguez, B., Lee, K.-F., Gan, W.-B., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4660-04.2005 · Cited by 290

Overexpression of tau in a nonneuronal cell induces long cellular processes.

Knops, J., Kosik, K. S., Lee, G., Pardee, J. D., Cohen-Gould, L., & McConlogue, L. (1991) · The Journal of cell biology · doi:10.1083/jcb.114.4.725 · Cited by 286

Genetic Analysis of Pathways to Parkinson Disease

Hardy, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.014 · Cited by 276

Neurodegeneration and neuroprotection in Parkinson disease

Fahn, S., & Sulzer, D. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.1.139 · Cited by 275

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease

Goedert, M., Cohen, E. S., Jakes, R., & Cohen, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81418-l · Cited by 272

Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP)

Ulery, P. G., Beers, J., Mikhailenko, I., Tanzi, R. E., Rebeck, G. W., Hyman, B. T., & Strickland, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7410 · Cited by 271

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

Hamamichi, S., Rivas, R. N., Knight, A. L., Cao, S., Caldwell, K. A., & Caldwell, G. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711018105 · Cited by 268

Atypical aging in down syndrome

Zigman, W. B. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1128 · Cited by 262

Megalin/gp330 mediates uptake of albumin in renal proximal tubule

Cui, S., Verroust, P. J., Moestrup, S. K., & Christensen, E. I. (1996) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1996.271.4.f900 · Cited by 260

Neurotoxic effects of TDP-43 overexpression in C. elegans

Ash, P. E. A., Zhang, Y., Roberts, C. M., Saldi, T. K., Hutter, H., Buratti, E., Petrucelli, L., & Link, C. D. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq230 · Cited by 258

Characterization of Notch3‐deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutation

Krebs, L. T., Xue, Y., Norton, C. R., Sundberg, J. P., Beatus, P., Lendahl, U., Joutel, A., & Gridley, T. (2003) · genesis · doi:10.1002/gene.10241 · Cited by 257

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

McColl, G., Roberts, B. R., Pukala, T. L., Kenche, V. B., Roberts, C. M., Link, C. D., Ryan, T. M., Masters, C. L., Barnham, K. J., Bush, A. I., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-57 · Cited by 257

Mutation within TARDBP leads to Frontotemporal Dementia without motor neuron disease

Borroni, B., Bonvicini, C., Alberici, A., Buratti, E., Agosti, C., Archetti, S., Papetti, A., Stuani, C., Luca, M. D., Gennarelli, M., et al. (2009) · Human Mutation · doi:10.1002/humu.21100 · Cited by 254

Two homologous regulatory genes, lin-12 and glp-1 , have overlapping functions

Lambie, E. J., & Kimble, J. E. (1991) · Development · doi:10.1242/dev.112.1.231 · Cited by 254

Expression of heat shock proteins in Alzheimer's disease

Hamos, J. E., Oblas, B., Pulaski-Salo, D., Wj, W., Bole, D. G., & Drachman, D. A. (1991) · Neurology · doi:10.1212/wnl.41.3.345 · Cited by 250

Alzheimer's disease and Down's syndrome

Mann, D. M. A. (1988) · Histopathology · doi:10.1111/j.1365-2559.1988.tb02018.x · Cited by 246

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

Tsuda, H., Han, S. M., Yang, Y., Tong, C., Qi, L. Y., Mohan, K., Haueter, C. M., Zoghbi, A. W., Harati, Y., Kwan, J. Y., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.039 · Cited by 243

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

Parker, J. A., Connolly, J. B., Wellington, C. L., Hayden, M., Dausset, J., & Néri, C. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231476398 · Cited by 242

PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1

Luo, W.-J., Wang, H., Li, H., Kim, B. S., Shah, S., Lee, H.-J., Thinakaran, G., Kim, T.-W., Yu, G., & Xu, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200648200 · Cited by 229

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

Daigle, I., & Li, C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.12045 · Cited by 228

Accelerated Oligomerization by Parkinson's Disease Linked α‐Synuclein Mutants

Conway, K. A., LEE, S. ‐., Rochet, J., Ding, T. T., Harper, J. D., Williamson, R. E., & Lansbury, P. T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06903.x · Cited by 224

Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-NeuronalCaenorhabditis elegansModel

Brignull, H. R., Moore, F. E., Tang, S. J., & Morimoto, R. I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0990-06.2006 · Cited by 220

C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer’s disease

Link, C. D. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.059 · Cited by 214

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Fonte, V. G., Kapulkin, W. J., Taft, A. S., Fluet, A., Friedman, D., & Link, C. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152313999 · Cited by 211

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Amos, L., & Schlieper, D. (2005) · Advances in protein chemistry · doi:10.1016/s0065-3233(04)71007-4 · Cited by 195

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Sprecher, C. A., Grant, F. J., Grimm, G., O’Hara, P. J., Norris, F., Norris, K. E., & Foster, D. C. (1993) · Biochemistry · doi:10.1021/bi00068a002 · Cited by 191

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Weyer, S. W., Klevanski, M., Delekate, A., Võikar, V., Aydin, D., Hick, M., Filippov, M. A., Drost, N., Schaller, K., Saar, M., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.119 · Cited by 187

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Lorent, K., Overbergh, L., Moechars, D., Strooper, B. D., LEUVEN, F. V., & BERGHE, H. V. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00555-j · Cited by 170

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