Cited by 49RNA modifications and cancerRNA regulation and diseaseEpigenetics and DNA Methylation

RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations

Open access
Romano, Giulia, Veneziano, Dario, Nigita, Giovanni, Nana-Sinkam, Serge P.·2018·Frontiers in Genetics

Abstract

Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification, as more than 150 distinct modification types have been reported. Since RNA modifications were first described over 50 years ago, our understanding of their functional relevance in cellular control mechanisms and phenotypes has truly progressed only in the last 15 years due to advancements in detection and experimental techniques. Specifically, the phenomenon of RNA methylation in the context of ncRNA has emerged as a novel process in the arena of epitranscriptomics. Methylated ncRNA molecules may indeed contribute to a potentially vast functional panorama, from regulation of post-transcriptional gene expression to adaptive cellular responses. Recent discoveries have uncovered novel dynamic mechanisms and new layers of complexity, paving the way to a greater understanding of the role of such phenomena within the broader molecular cellular context of human disease.

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Crossref · 10.3389/fgene.2018.00243

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  • ncRNAs, due to their conspicuous amount and proportion in the transcriptome, play a central role in epigenetics with an incidence in all functional levels.

    “Overall, ncRNAs, due to their conspicuous amount and proportion in the transcriptome, play a central role in epigenetics with an incidence in all functional levels (Figure 2).”

    From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [79]

    The Abstract (page unavailable) describes methylated ncRNAs as potentially contributing to functions ranging from post-transcriptional gene regulation to adaptive cellular responses. The Introduction (page unavailable) says RNA modifications can affect many aspects of cellular physiology. Neither passage establishes that ncRNAs are conspicuously abundant in the transcriptome or that their abundance makes them central to epigenetics at all functional levels. (LLM, conf=0.82)

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  • ncRNAs could interact with mRNA methylation through a different mechanism.

    “Through a different mechanism, ncRNAs could interact with mRNA methylation [79].”

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Authors
Romano, G., Veneziano, D., Nigita, G., & Nana-Sinkam, S. P.
Affiliations
  • Virginia Commonwealth University (US)
  • The Ohio State University (US)
Corresponding author
Nana-Sinkam, Serge P.
Venue
Frontiers in Genetics
Published
2018-07-12
Volume
9
Pages
243-243
ISSN
1664-8021 (ISSN-L)
OpenAlex
W2808810957
Cited by
49
References
141
Citations by year
2025: 1 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 16 · 2020: 7 · 2019: 5 · 2018: 1
FWCI
2.58
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
RNA methylation, non-coding RNA, epitranscriptomics, post-transcriptional modification, RNA modification detection, post-transcriptional regulation, cellular adaptation, human disease

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