RNA Methylation in ncRNA: Classes, Detection, and Molecular Associations
Open accessAbstract
Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification, as more than 150 distinct modification types have been reported. Since RNA modifications were first described over 50 years ago, our understanding of their functional relevance in cellular control mechanisms and phenotypes has truly progressed only in the last 15 years due to advancements in detection and experimental techniques. Specifically, the phenomenon of RNA methylation in the context of ncRNA has emerged as a novel process in the arena of epitranscriptomics. Methylated ncRNA molecules may indeed contribute to a potentially vast functional panorama, from regulation of post-transcriptional gene expression to adaptive cellular responses. Recent discoveries have uncovered novel dynamic mechanisms and new layers of complexity, paving the way to a greater understanding of the role of such phenomena within the broader molecular cellular context of human disease.
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ncRNAs, due to their conspicuous amount and proportion in the transcriptome, play a central role in epigenetics with an incidence in all functional levels.
“Overall, ncRNAs, due to their conspicuous amount and proportion in the transcriptome, play a central role in epigenetics with an incidence in all functional levels (Figure 2).”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [79]
The Abstract (page unavailable) describes methylated ncRNAs as potentially contributing to functions ranging from post-transcriptional gene regulation to adaptive cellular responses. The Introduction (page unavailable) says RNA modifications can affect many aspects of cellular physiology. Neither passage establishes that ncRNAs are conspicuously abundant in the transcriptome or that their abundance makes them central to epigenetics at all functional levels. (LLM, conf=0.82)
Experimental — accuracy not yet measuredncRNAs could interact with mRNA methylation through a different mechanism.
“Through a different mechanism, ncRNAs could interact with mRNA methylation [79].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [79]
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- Authors
- Romano, G., Veneziano, D., Nigita, G., & Nana-Sinkam, S. P.
- Affiliations
- Virginia Commonwealth University (US)
- The Ohio State University (US)
- Corresponding author
- Nana-Sinkam, Serge P.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2018-07-12
- Volume
- 9
- Pages
- 243-243
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC6052889
- OpenAlex
- W2808810957
- Cited by
- 49
- References
- 141
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 16 · 2020: 7 · 2019: 5 · 2018: 1
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- RNA methylation, non-coding RNA, epitranscriptomics, post-transcriptional modification, RNA modification detection, post-transcriptional regulation, cellular adaptation, human disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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