Role of female sex hormones, estradiol and progesterone, in mast cell behavior
Open accessAbstract
Female sex hormones have long been suspected to have an effect on mast cell (MC) behavior. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different prevalence in females than in males. Further, serum IgE levels are much higher in allergic female mice compared to male mice. Ovariectomized rats developed less airway inflammation compared to sham controls. Following estrogen replacement ovariectomized rats re-established airway inflammation levels' found in intact females. In humans, a much higher asthma prevalence was found in women at reproductive age as compared to men. Serum levels of estradiol and progesterone have been directly correlated with the clinical and functional features of asthma. Around 30-40% of women who have asthma experienced worsening of their symptoms during the perimenstrual phase, the so-called perimenstrual asthma. Postmenopausal women receiving hormone replacement therapy have an increased risk of new onset of asthma. Beside, estrus cycle dependent changes on female sex hormones are related to changes on MC number in mouse uterine tissue and estradiol and progesterone were shown to induce uterine MC maturation and degranulation. We will discuss here the currently available information concerning the role of these female sex hormones on MC behavior.
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Sex hormones have crucial effects on mast cell behavior in physiological and several pathological situations.
“Strong data in the last years reinforced the idea that sex hormones have crucial effects on MCs behavior, not only in physiological conditions, but also in several pathological situations [15–18].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [18]
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Cites
Surveillance for asthma--United States, 1980-1999.
Mannino, D. M., Homa, D. M., Akinbami, L. J., Moorman, J. E., Gwynn, C., & Redd, S. C. (2002) · PubMed · Cited by 1,699 · see citing works
Estradiol activates mast cells via a non-genomic estrogen receptor-α and calcium influx
Zaitsu, M., Narita, S.-I., Lambert, K. C., Grady, J. J., Estes, D. M., Curran, E. M., Brooks, E. G., Watson, C. S., Goldblum, R. M., & Midoro-Horiuti, T. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.09.030 · Cited by 262 · cited 5× · see citing works
“Among others, female sex hormones, estradiol and progesterone, have been proposed to activate MC (Chancey et al., 2005; Vasiadi et al., 2006; Narita et al., 2007; Zaitsu et al., 2007; Jensen et al., 2010; Jing et al., 2011; Walter et al., 2011).”
BackgroundInfluentialSchatz, M. N., & Camargo, C. A. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61533-5 · Cited by 225 · see citing works
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies
Carey, M. A., Card, J. W., Voltz, J. W., Germolec, D. R., Korach, K. S., & Zeldin, D. C. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00174.2007 · Cited by 218 · see citing works
Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy
de Marco, R., Locatelli, F., Cerveri, I., Bugiani, M., Marinoni, A., & Giammanco, G. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.125600 · Cited by 205 · see citing works
Narita, S.-I., Goldblum, R. M., Watson, C. S., Brooks, E. G., Estes, D. M., Curran, E. M., & Midoro-Horiuti, T. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9378 · Cited by 186 · see citing works
Barr, R. G., Wentowski, C. C., Grodstein, F., Somers, S. C., Stampfer, M. J., Schwartz, J. D., Speizer, F. E., & Camargo, C. A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.4.379 · Cited by 168 · see citing works
Watsona, C. (1999) · Steroids · doi:10.1016/s0039-128x(98)00107-x · Cited by 165 · see citing works
Minireview: Extranuclear Steroid Receptors: Roles in Modulation of Cell Functions
Levin, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0284 · Cited by 153 · see citing works
The multiple roles of phosphoinositide 3-kinase in mast cell biology
Kim, M., Rådinger, M., & Gilfillan, A. M. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.004 · Cited by 148 · see citing works
Jensen, F., Woudwyk, M., Teles, A., Woidacki, K., Taran, F., Costa, S., Malfertheiner, S. F., & Zenclussen, A. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014409 · Cited by 145 · cited 6× · see citing works
“Among others, female sex hormones, estradiol and progesterone, have been proposed to activate MC (Chancey et al., 2005; Vasiadi et al., 2006; Narita et al., 2007; Zaitsu et al., 2007; Jensen et al., 2010; Jing et al., 2011; Walter et al., 2011).”
BackgroundMethodResultInfluentialSelf-citationPerimenstrual asthma: A syndrome without known cause or cure
Vrieze, A., Postma, D. S., & Kerstjens, H. A. M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1676 · Cited by 132 · see citing works
Peptidergic pathway in human skin and rat peritoneal mast cell activation
Mousli, M., Hugli, T. E., Landry, Y., & Bronner, C. (1994) · Immunopharmacology · doi:10.1016/0162-3109(94)90002-7 · Cited by 131 · see citing works
Asthma prevalence in 1973, 1988 and 2003
Burr, M. L. (2006) · Thorax · doi:10.1136/thx.2005.045682 · Cited by 124 · see citing works
Progesterone Inhibits Mast Cell Secretion
Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200601900408 · Cited by 107 · see citing works
Pang, X., Cotreau‐Bibbo, M. M., Sant, G. R., & Theoharides, T. C. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07303.x · Cited by 103 · see citing works
(1990) · PubMed · Cited by 85 · see citing works
Chen, W., Beck, I., Schober, W., Brockow, K., Effner, R., Buters, J. T. M., Behrendt, H., & Ring, J. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00969.x · Cited by 82 · see citing works
Regulation of Allergic Lung Inflammation in Rats: Interaction between Estradiol and Corticosterone
de Oliveira, A. P. L., Oliveira-Filho, R. M., da Silva, Z. L., Borelli, P., & de Lima, W. T. (2003) · NeuroImmunoModulation · doi:10.1159/000072965 · Cited by 80 · see citing works
Theoharides, T. C., Dimitriadou, V., Létourneau, R., Rózniecki, J., Vliagoftis, H., & Boucher, W. S. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90030-j · Cited by 72 · see citing works
Proteins of Multiple Classes May Participate in Nongenomic Steroid Actions
Watson, C. S., & Gametchu, B. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801106 · Cited by 71 · see citing works
Corteling, R. L., & Trifilieff, A. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-4 · Cited by 69 · see citing works
Mast cell-committed progenitors
Kitamura, Y., & Ito, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505073102 · Cited by 69 · see citing works
Adapters in the organization of mast cell signaling
Álvarez‐Errico, D., Lessmann, E., & Rivera, J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00834.x · Cited by 60 · see citing works
Gonadal Steroids Regulate the Number and Activational State of Mast Cells in the Medial Habenula1
Wilhelm, M., King, B. G., Silverman, A., & Silver, R. (2000) · Endocrinology · doi:10.1210/endo.141.3.7352 · Cited by 55 · see citing works
Aydin, Y., Tunçel, N., Gürer, F., Tunçel, M., Koşar, M., & Oflaz, G. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(98)00027-0 · Cited by 39 · see citing works
Mast cell distribution in the uterus of cycling and pregnant hamsters
Harvey, E. B. (1964) · The Anatomical Record · doi:10.1002/ar.1091480309 · Cited by 35 · see citing works
Effect of Oestradiol on Mast Cell Number and Histamine Level in the Mammary Glands of Rat
Jing, H., Wang, Z., & Chen, Y. (2011) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.2011.01120.x · Cited by 34 · see citing works
Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogen
Chancey, A. L., Gardner, J. D., Murray, D. B., Brower, G. L., & Janicki, J. S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00765.2004 · Cited by 34 · see citing works
Mast cells in the normal uterus and in dysfunctional uterine bleeding
Drudy, L., SHEPPARD, B. L., & Bonnar, J. (1991) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(91)90057-r · Cited by 33 · see citing works
Bradding, P. (2005) · KARGER eBooks · doi:10.1159/000087643 · Cited by 30 · see citing works
Is the menstrual cycle affecting the skin prick test reactivity?
Kırmaz, C., Yüksel, H., Mete, N., Değirmenci, P. B., & Baytur, Y. B. (2004) · PubMed · Cited by 24 · see citing works
Karaca, T., Arikan, S., Kalender, H., & Yörük, M. (2008) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2007.00934.x · Cited by 21 · see citing works
Jaiswal, K., & Krishna, A. (1996) · PubMed · Cited by 16 · see citing works
Walter, J., Klein, C., & Wehrend, A. (2011) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2011.01897.x · Cited by 14 · see citing works
Gonadal Steroids Regulate the Number and Activational State of Mast Cells in the Medial Habenula
Wilhelm, M. (2000) · Endocrinology · doi:10.1210/en.141.3.1178 · Cited by 14 · see citing works
Tamura, K., & Kogo, H. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00216-2 · Cited by 12 · see citing works
(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone
Flagged first, then by citations
2 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
New Look at BTEX: Are Ambient Levels a Problem?
Bolden, A. L., Kwiatkowski, C. F., & Colborn, T. (2015) · Environmental Science & Technology · doi:10.1021/es505316f · Cited by 458 · see citing works
Sex hormones in the modulation of irritable bowel syndrome
Mulak, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2433 · Cited by 277 · see citing works
Non‐IgE mediated mast cell activation
Redegeld, F. A., Yu, Y., Kumari, S., Charles, N., & Blank, U. (2018) · Immunological Reviews · doi:10.1111/imr.12629 · Cited by 212 · see citing works
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
Avona, A., Burgos-Vega, C., Burton, M. D., Akopian, A. N., Price, T. J., & Dussor, G. O. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-19.2019 · Cited by 199 · see citing works
Mast cells on the mind: new insights and opportunities
Silver, R., & Curley, J. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.001 · Cited by 178 · see citing works
Sexual dimorphism in bacterial infections
Vázquez-Martínez, E. R., García-Gómez, E., Camacho‐Arroyo, I., & González‐Pedrajo, B. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0187-5 · Cited by 172 · see citing works
An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens
Paredes, S., Cantillo, S., Candido, K. D., & Knežević, N. N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225729 · Cited by 164 · see citing works
Mendoza, M. S., & Morales‐Montor, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00348 · Cited by 133 · see citing works
Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study
Triebner, K., Johannessen, A., Puggini, L., Benediktsdóttir, B., Bertelsen, R. J., Bifulco, E., Dharmage, S. C., Dratva, J., Franklin, K. A., Gíslason, Þ., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.019 · Cited by 111 · see citing works
Sex Differences in Stress Response: Classical Mechanisms and Beyond
Hodes, G. E., Bangasser, D. A., Sotiropoulos, I., Kokras, N., & Dalla, C. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231005090134 · Cited by 95 · see citing works
Pigrau, M., Rodiño‐Janeiro, B. K., Casado‐Bedmar, M., Lobo, B., Vicario, M., Santos, J., & Alonso, C. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12717 · Cited by 79 · see citing works
Deciphering sex differences in the immune system and depression
Rainville, J. R., Tsyglakova, M., & Hodes, G. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.004 · Cited by 69 · see citing works
Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update
Koper, I., Hufnagl, K., & Ehmann, R. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0177-9 · Cited by 63 · see citing works
How hormones may modulate human skin pigmentation in melasma: An in vitro perspective
Cario, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13915 · Cited by 63 · see citing works
Abd‐Elhafeez, H. H., & Soliman, S. A. (2016) · Cells Tissues Organs · doi:10.1159/000452243 · Cited by 62 · see citing works
Wang, H., Jessup, J. A., Zhao, Z., da Silva, J. S., Lin, M., MacNamara, L. M., Ahmad, S., Chappell, M. C., Ferrario, C. M., & Groban, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076992 · Cited by 57 · see citing works
Park, S., Kim, J., Kim, H.-J., Seo, B., Kwon, O. Y., Chang, H. S., Kwon, H., Kim, T., Kim, H., Park, C., et al. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.4.387 · Cited by 56 · see citing works
Muñoz-Cruz, S., Mendoza-Rodríguez, Y., Nava-Castro, K. E., Yepez-Mulia, L., & Morales-Montor, J. (2015) · Journal of Immunology Research · doi:10.1155/2015/351829 · Cited by 54 · see citing works
Association between asthma and female sex hormones
Baldaçara, R. P. D. C., & Silva, I. (2017) · Sao Paulo Medical Journal · doi:10.1590/1516-3180.2016.011827016 · Cited by 54 · see citing works
Symptomatology of irritable bowel syndrome and inflammatory bowel disease during the menstrual cycle
Bharadwaj, S., Barber, M. D., Graff, L. A., & Shen, B. (2015) · Gastroenterology report · doi:10.1093/gastro/gov010 · Cited by 52 · see citing works
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Chiarella, S. E., Cardet, J. C., & Prakash, Y. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.007 · Cited by 40 · see citing works
Brock, I., Prendergast, W., & Maitland, A. L. (2021) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31940 · Cited by 39 · see citing works
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Lampiasi, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105414 · Cited by 39 · see citing works
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Afrin, L. B. (2016) · Translational Research · doi:10.1016/j.trsl.2016.01.003 · Cited by 39 · see citing works
Qin, B. Y., Dong, L., Guo, X., Jiang, J., He, Y.-X., Wang, X., Li, L., & Zhao, J. (2014) · PubMed Central · Cited by 38 · see citing works
Gender differences in anaphylaxis
Salvati, L., Vitiello, G., & Parronchi, P. (2019) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000568 · Cited by 38 · see citing works
Campanile, G., Baruselli, P. S., Limone, A., & D’Occhio, M. J. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.02.020 · Cited by 37 · see citing works
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Ismail, A., Kennedy, L. L., & Francis, H. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.010 · Cited by 36 · see citing works
Szukiewicz, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512195 · Cited by 36 · see citing works
Fan, Z., Che, H., Yang, S., & Chen, C. (2019) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2019.03.001 · Cited by 35 · see citing works
Yalçınkaya, A. S., Yalçınkaya, R., Sardh, F., & Landegren, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1501364 · Cited by 34 · see citing works
Falcone, D., Richters, R. J. H., Uzunbajakava, N. E., van Erp, P. E. J., & van de Kerkhof, P. C. M. (2017) · European Journal of Dermatology · doi:10.1684/ejd.2016.2913 · Cited by 31 · see citing works
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El-Fadaly, A. B., El-Shaarawy, E. A. A., Rizk, A. A. E.-E., Nasralla, M. M., & Shuaib, D. M. (2014) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2014.06.005 · Cited by 29 · see citing works
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Franconi, F., Rosano, G. M. C., Basili, S., Montella, A., & Campesi, I. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.118 · Cited by 28 · see citing works
The role of sex in particle‐induced inflammation and injury
Ray, J. L., Fletcher, P., Burmeister, R., & Holian, A. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1589 · Cited by 26 · see citing works
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Volle, G., Fraison, J. B., Gobert, D., Goulenok, T. M., Dhôte, R., Fain, O., Chiappe, S. G., Lhote, F., Papo, T., Thuillier, A., et al. (2016) · Arthritis Care & Research · doi:10.1002/acr.23155 · Cited by 26 · see citing works
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Lopes, D. M., Denk, F., Chisholm, K. I., Suddason, T., Durrieux, C., Thakur, M., Gentry, C., & McMahon, S. B. (2017) · Pain · doi:10.1097/j.pain.0000000000000917 · Cited by 24 · see citing works
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Casanova, E., Sharp, J., Edelson, S., Kelly, D., & Casanova, M. (2018) · Behavioral Sciences · doi:10.3390/bs8030035 · Cited by 18 · see citing works
Irritable Bowel Syndrome and the Menstrual Cycle
Pati, G. K., Kar, C., Narayan, J., Uthansingh, K., Behera, M. K., Sahu, M. K., Mishra, D., & Singh, A. (2021) · Cureus · doi:10.7759/cureus.12692 · Cited by 17 · see citing works
Mast cell, the peculiar member of the immune system: A homeostatic aspect
Csaba, G. (2015) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.62.2015.3.1 · Cited by 17 · see citing works
Mast cells—Good guys with a bad image?
Meyer, N., & Zenclussen, A. C. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13002 · Cited by 17 · see citing works
Self-citationPreis, S., Claussen, C., Ziehfreund, S., Biedermann, T., Horster, S., & Zink, A. (2024) · World Allergy Organization Journal · doi:10.1016/j.waojou.2024.100974 · Cited by 16 · see citing works
Anaphylaxis-induced hyperfibrinolysis in pregnancy
Truong, H. T., & Browning, R. M. (2015) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2014.12.009 · Cited by 16 · see citing works
Onset Mechanism and Pharmaceutical Management of Dry Skin
Ooi, K. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00150 · Cited by 15 · see citing works
Endometriosis through an immunological lens: a pathophysiology based in immune dysregulation
McCallion, A., Sisnett, D. J., Zutautas, K. B., Hayati, D., Spiess, K. G., Aleksieva, S., Lingegowda, H., Koti, M., & Tayade, C. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00062 · Cited by 16 · see citing works
Regular exercise modulates cardiac mast cell activation in ovariectomized rats
Phungphong, S., Kijtawornrat, A., Wattanapermpool, J., & Bupha‐Intr, T. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0409-0 · Cited by 15 · see citing works
Visnyaiová, K., Varga, I., Feitscherova, C., Pavlíková, L., Záhumenský, J., & Mikušová, R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1325565 · Cited by 13 · see citing works
Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain
Pergolizzi, J. V., LeQuang, J. A., Coluzzi, F., El-Tallawy, S. N., Magnusson, P., Ahmed, R. S., Varrassi, G., & Porpora, M. G. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2425727 · Cited by 14 · see citing works
Laha, A., Sarkar, T., Dey, D., Mondal, P., Srijit Bhattacharya, B., Moitra, S., Saha, G. K., & Podder, S. (2019) · Journal of Medical Entomology · doi:10.1093/jme/tjz088 · Cited by 13 · see citing works
Park, H., Lee, J. Y., Song, A., Jung, M., Kim, M., Sohn, I., Kim, M. J., Cho, J., Ahn, K., & Kim, J. (2018) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-151117-0197 · Cited by 13 · see citing works
On Connective Tissue Mast Cells as Protectors of Life, Reproduction, and Progeny
Norrby, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084499 · Cited by 11 · see citing works
Sanctis, J. B. D., Noria, G. B., & García, A. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020862 · Cited by 13 · see citing works
Antihistamine use and risk of ovarian cancer: A population-based case-control study
Verdoodt, F., Pottegård, A., Dehlendorff, C., Jäättelä, M., Hallas, J., Friis, S., & Kjær, S. K. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.11.014 · Cited by 12 · see citing works
Kaur, S., McDonald, H., Tongkhuya, S. A., Lopez, C. M. C., Ananth, S., Hickman, T. M., & Averitt, D. L. (2021) · Neurobiology of Pain · doi:10.1016/j.ynpai.2021.100073 · Cited by 12 · see citing works
Changes in the mast cell distribution in the canine ovary and uterus throughout the oestrous cycle
Hamouzová, P., Čížek, P., Bartoskova, A., Vitasek, R., & Tichý, F. (2020) · Reproduction in Domestic Animals · doi:10.1111/rda.13641 · Cited by 11 · see citing works
Semik-Orzech, A., Skoczyński, S., & Pierzchała, W. (2017) · European Annals of Allergy and Clinical Immunology · doi:10.23822/eurannaci.1764-1489.09 · Cited by 10 · see citing works
Do mast cells contribute to the continued survival of vertebrates?
Norrby, K. (2022) · Apmis · doi:10.1111/apm.13264 · Cited by 10 · see citing works
Vesselinova, L. (2015) · Electromagnetic Biology and Medicine · doi:10.3109/15368378.2015.1076449 · Cited by 9 · see citing works
Mast cell in infantile hemangioma
Xia, M., Liu, W., & Hou, F. Y. S. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1304478 · Cited by 8 · see citing works
Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome
Weinstock, L. B., Afrin, L. B., Reiersen, A. M., Brook, J. B., Blitshteyn, S., Ehrlich, G., Schofield, J. R., Kinsella, L. J., Kaufman, D. L., Dempsey, T. T., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101048 · Cited by 9 · see citing works
A focused report on progestogen hypersensitivity
Patel, D. H., Fine, L. M., & Bernstein, J. A. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2182292 · Cited by 8 · see citing works
Ganai, I., Saha, I., Banerjee, P., Laha, A., Sultana, S., Sultana, N., Biswas, H., Moitra, S., & Podder, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1089514 · Cited by 8 · see citing works
Effect of Gender and Special Considerations for Women in Mastocytosis and Anaphylaxis
Ellingwood, S., & Kovalszki, A. (2023) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2023.04.004 · Cited by 8 · see citing works
Churchill, M., Holdsworth‐Carson, S. J., Cowley, K. J., Luu, J., Simpson, K. J., Healey, M., Rogers, P. A. W., & Donoghue, J. F. (2023) · Biomolecules · doi:10.3390/biom13060965 · Cited by 7 · see citing works
Utami, A. M., Halfwerk, J. B. G., de Boer, O. J., Mackaaij, C., Pabittei, D. R., van der Horst, C. M. A. M., Meijer‐Jorna, L. B., & van der Wal, A. C. (2023) · European journal of medical research · doi:10.1186/s40001-023-01436-5 · Cited by 7 · see citing works
Urticaria and Angioedema in Pregnancy
Kadar, L., & Kivity, S. (2013) · Current Dermatology Reports · doi:10.1007/s13671-013-0061-y · Cited by 7 · see citing works
Mastocytosis and Skin Cancer: The Current State of Knowledge
Kaszuba, A., Sławińska, M., Żółkiewicz, J., Sobjanek, M., Nowicki, R. J., & Lange, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129840 · Cited by 7 · see citing works
Effect of Long-term Hyperimmunization on the Presence of Mast Cells in the Endometrium of the Mare
Witkowski, M., Katkiewicz, M., Zając, S., & Kochan, J. (2015) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2015.03.003 · Cited by 6 · see citing works
Hamouzová, P., Čížek, P., Jekl, V., Goździewska‐Harłajczuk, K., & Klećkowska‐Nawrot, J. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2021.04.003 · Cited by 6 · see citing works
Deciphering New Molecular Mechanisms of Mast Cell Activation
Blank, U., & Benhamou, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00100 · Cited by 5 · see citing works
Woo, Y. R., Jung, Y., Jeong, S. W., & Park, H. J. (2020) · Experimental Dermatology · doi:10.1111/exd.14233 · Cited by 5 · see citing works
Chen, T., Yip, H., Wang, J., Chang, C., Ci, H., Hsu, C. Y., & Chang, C. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.16109 · Cited by 5 · see citing works
Fuda, S., Angelini, D. F., Colopi, A., Guida, E., Onorato, A., Grimaldi, P., Travaglini, S., Jannini, E. A., & Dolci, S. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111820 · Cited by 5 · see citing works
Mahra, K., Singh, V., & Shin, J. (2025) · Genomics & Informatics · doi:10.1186/s44342-025-00051-6 · Cited by 4 · see citing works
Number and Distribution of Mast Cells in Reproductive Systems of Gravid and Non-Gravid Female Mice
Glavaški, M., Banović, P., & Lalošević, D. (2019) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2019-0047 · Cited by 4 · see citing works
Joshi, S. R., & Khan, D. A. (2018) · Springer eBooks · doi:10.1007/978-3-030-03395-8_8 · Cited by 4 · see citing works
KÜRÜM, A., Özen, A., Karahan, S., & Özcan, Z. (2014) · Kafkas Universitesi Veteriner Fakultesi Dergisi · Cited by 4 · see citing works
- Authors
- Zierau, O., Zenclussen, A. C., & Jensen, F.
- Affiliations
- Technische Universität Dresden (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Jensen, Federico
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 169-169
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC3377947
- OpenAlex
- W2104761060
- Cited by
- 148
- References
- 40
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 11 · 2023: 14 · 2022: 7 · 2021: 14 · 2020: 6 · 2019: 19 · 2018: 10 · 2017: 11 · 2016: 6 · 2015: 12 · 2014: 8 · 2013: 7
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Immunology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- mast cells, estradiol, progesterone, female sex hormones, hormone receptors, asthma, hormone replacement therapy, airway inflammation, ovariectomy, mast cell degranulation, estrous cycle, sex differences in allergy
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