Cited by 107Mast cells and histamineAsthma and respiratory diseasesEstrogen and related hormone effects

Progesterone Inhibits Mast Cell Secretion

Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., Theoharides, T.C.·2006·International Journal of Immunopathology and Pharmacology

Abstract

Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.

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Crossref · 10.1177/039463200601900408

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C.
Affiliations
  • Tufts Medical Center (US)
  • National and Kapodistrian University of Athens (GR)
  • Tufts University (US)
Corresponding author
Theoharides, T.C.
Venue
International Journal of Immunopathology and Pharmacology
Published
2006-10
Volume
19
Issue
4
Pages
787-794
ISSN
  • 0394-6320 (ISSN-L)
  • 2058-7384
OpenAlex
W2142403829
Cited by
107
References
42
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Immunopathology and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk042409-03)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK42409)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
progesterone, mast cells, histamine release, substance P, estrogen receptor, estradiol, tamoxifen, peritoneal mast cells, pregnancy, inflammatory diseases, irritable bowel syndrome, interstitial cystitis, migraine, allergic reactions
MeSH terms
Animals, Male, Mast Cells, Progesterone, Rats, Sprague-Dawley, Rats

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