Progesterone Inhibits Mast Cell Secretion
Abstract
Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.
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Sexual hormones regulate mast cell functionality and distribution in several tissues.
“A number of in vivo and in vitro studies suggest that sexual hormones regulate MCs functionality and distribution in several tissues [10–14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
Progesterone (100 nM) inhibits histamine secretion from peritoneal mast cells purified from male rats stimulated immunologically.
“This is consistent with previous studies reporting that progesterone (100 nM) inhibits histamine secretion from PMCs purified from male rats stimulated immunologically [14].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [14]
Cites
Mast cells in the development of adaptive immune responses
Galli, S. J., Nakae, S., & Tsai, M. M. (2005) · Nature Immunology · doi:10.1038/ni1158 · Cited by 1,280 · see citing works
Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.
Ahmed, S. A., Penhale, W. J., & Talal, N. (1985) · PubMed · Cited by 815 · see citing works
Regulation of the Immune System by Sex Steroids*
Grossman, C. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-3-435 · Cited by 671 · see citing works
Effects of gender and sex steroids on the immune response
Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587 · see citing works
Mast cells are closely apposed to nerves in the human gastrointestinal mucosa
Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445 · see citing works
Critical role of mast cells in inflammatory diseases and the effect of acute stress
Theoharides, T. C., & Cochrane, D. E. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.041 · Cited by 437 · see citing works
Self-citationThe Natural History of Interstitial Cystitis: A Survey of 374 Patients
Koziol, J. A., Clark, D. C., Gittes, R. F., & Tan, E. M. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)36120-7 · Cited by 351 · see citing works
Identification of mast cell progenitors in adult mice
Chen, C., Grimbaldeston, M. A., Tsai, M. M., Weissman, I. L., & Galli, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504197102 · Cited by 312 · see citing works
Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome
Accarino, A. M., Azpiroz, F., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90434-4 · Cited by 282 · see citing works
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence
Theoharides, T. C., Kempuraj, D., & Sant, G. R. (2001) · Urology · doi:10.1016/s0090-4295(01)01129-3 · Cited by 277 · see citing works
Self-citationDimtriadou, V., Buzzi, M. G., Moskowitz, M. A., & Theoharides, T. C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90253-k · Cited by 275 · see citing works
Self-citationIncreased number of substance P positive nerve fibres in interstitial cystitis
Pang, X., Marchand, J. E., Sant, G. R., Kream, R. M., Theoharides, T. C., & J. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07384.x · Cited by 248 · see citing works
Self-citationDifferential release of serotonin and histamine from mast cells
Theoharides, T. C., Bondy, P. K., Tsakalos, N. D., & Askenase, P. W. (1982) · Nature · doi:10.1038/297229a0 · Cited by 244 · see citing works
Self-citationSuggestive evidence for a direct innervation of mucosal mast cells
Newson, B., Dahlström, A. B., Enerbäck, L., & Ahlman, H. K. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90153-7 · Cited by 235 · see citing works
Homology of the rat basophilic leukemia cell and the rat mucosal mast cell.
Seldin, D. C., Adelman, S., Austen, K. F., Stevens, R. L., Hein, A., CAULFIELD, J. P., & Woodbury, R. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3871 · Cited by 230 · see citing works
Premenstrual exacerbation of asthma.
Gibbs, C. J., Coutts, I. I., Lock, R. B., Finnegan, O. C., & White, R. J. (1984) · Thorax · doi:10.1136/thx.39.11.833 · Cited by 218 · see citing works
Sex steroid regulation of autoimmunity
Grossman, C. J., Roselle, G. A., & Mendenhall, C. L. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90287-f · Cited by 203 · see citing works
Activation of Bladder Mast Cells in Interstitial Cystitis: A Light and Electron Microscopic Study
Theoharides, T. C., Sant, G. R., El-Mansoury, M., Létourneau, R., Ucci, A. A., & Meares, E. M. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67669-9 · Cited by 183 · see citing works
Self-citationLétourneau, R., Pang, X., Sant, G. R., & Theoharides, T. C. (1996) · British Journal of Urology · doi:10.1046/j.1464-410x.1996.08178.x · Cited by 160 · see citing works
Self-citationEstradiol Augments while Tamoxifen Inhibits Rat Mast Cell Secretion
Vliagoftis, H., Dimitriadou, V., Boucher, W., Rozniecki, J. J., Correia, I., Raam, S., & Theoharides, T. C. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236217 · Cited by 158 · see citing works
Self-citationPLASMA LEVELS OF PROGESTERONE IN PREGNANCY MEASURED BY A RAPID COMPETITIVE PROTEIN BINDING TECHNIQUE
Johansson, E. D. B. (1969) · European Journal of Endocrinology · doi:10.1530/acta.0.0610607 · Cited by 155 · see citing works
Interstitial Cystitis: A Neuroimmunoendocrine Disorder <sup>a</sup>
THEOHARIDES, T. C., PANG, X., LETOURNEAU, R., & SANT, G. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09601.x · Cited by 139 · see citing works
Self-citationDaëron, M., Sterk, A. R., Hirata, F., & Ishizaka, T. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.3.1212 · Cited by 104 · see citing works
Pang, X., Cotreau‐Bibbo, M. M., Sant, G. R., & Theoharides, T. C. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07303.x · Cited by 103 · see citing works
Self-citationInterstitial Cystitis: Correlation with Nerve Fibres, Mast Cells and Histamine
Lundeberg, T., Liedberg, H., Nordling, L., Theodorsson, E., OWZARSKI, A., & Ekman, P. (1993) · British Journal of Urology · doi:10.1111/j.1464-410x.1993.tb15986.x · Cited by 94 · see citing works
(1990) · PubMed · Cited by 85 · see citing works
MENSTRUAL CYCLE AFFECTS BLADDER PAIN SENSATION IN SUBJECTS WITH INTERSTITIAL CYSTITIS
Powell, T., Ness, T. J., Cannon, R., Lloyd, L. K., Weigent, D. A., & Fillingim, R. B. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176747.40242.3d · Cited by 77 · see citing works
Spanos, C. P., El-Mansoury, M., Létourneau, R., Minogiannis, P., Greenwood, J., Siri, P., Sant, G. R., & Theoharides, T. C. (1996) · Urology · doi:10.1016/s0090-4295(96)00239-7 · Cited by 53 · see citing works
Self-citationTakei, M., Burgoyne, D. L., & Andersen, R. J. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830909 · Cited by 50 · see citing works
Daily plasma progesterone levels during the menstrual cycle
Woolever, C. A. (1963) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)35633-2 · Cited by 37 · see citing works
Immunomodulators for treatment of interstitial cystitis
Theoharides, T. C., & Sant, G. R. (2005) · Urology · doi:10.1016/j.urology.2004.08.052 · Cited by 33 · see citing works
Self-citationHormonal pattern in women affected by rheumatoid arthritis
Valentino, R., Savastano, S., Tommaselli, A. P., Riccio, A., Mariniello, P., Pronesti, G., Divitiis, P. M. D., & Lombardi, G. (1993) · Journal of Endocrinological Investigation · doi:10.1007/bf03347683 · Cited by 29 · see citing works
Histamine Releasing Activity of Natural Estrogens.
Shelesnyak, M. C. (1959) · Experimental Biology and Medicine · doi:10.3181/00379727-100-24762 · Cited by 28 · see citing works
Histamine Metabolism During the Menstrual Cycle
Jonassen, F., Granérus, G., & Wetterqvist, H. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609158501 · Cited by 27 · see citing works
Inhibition of murine cytotoxic T cell responses by progesterone
Männel, D. N., Falk, W., & Yron, I. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90181-o · Cited by 27 · see citing works
Age–sex incidence in symptomatic allergies: an excess of females in the child-bearing years
Wormald, P. J. (1977) · Journal of Hygiene · doi:10.1017/s0022172400052827 · Cited by 26 · see citing works
Settipane, R. A., & Simon, R. A. (1989) · PubMed · Cited by 24 · see citing works
Effect of Pregnancy on Airway Responsiveness and Asthma Severity: Relationship to Serum Progesterone
Juniper, E. F., Daniel, E. E., Roberts, R. S., Kline, P. A., HARGREAVE, F. E., & Newhouse, M. T. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.3_pt_2.s78 · Cited by 19 · see citing works
Uchida, H., Mizuno, K., Yoshida, A., & Ueda, H. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00135-3 · Cited by 17 · see citing works
Neuroimmune Connections and Regulation of Function in the Urinary Bladder
Theoharides, T. C., & Sant, G. R. (2003) · CRC Press eBooks · doi:10.3109/9780203008966-20 · Cited by 14 · see citing works
Self-citationNeuroimmune Interactions in the Lung
Undem, B. J., & Weinreich, D. M. (2003) · CRC Press eBooks · doi:10.3109/9780203008966-17 · Cited by 11 · see citing works
Kita, E., Hamuro, A., Oku, D., Nishikawa, F., Yasui, K., Emoto, M., Katsui, N., & Kashiba, S. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90164-m · Cited by 5 · see citing works
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Sex differences and sex steroids in lung health and disease
Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395 · see citing works
Gender difference, sex hormones, and immediate type hypersensitivity reactions
Chen, W., Mempel, M., Schober, W., Behrendt, H., & Ring, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01880.x · Cited by 370 · see citing works
Roved, J., Westerdahl, H., & Hasselquist, D. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.017 · Cited by 348 · see citing works
Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342 · see citing works
Sex hormones in the modulation of irritable bowel syndrome
Mulak, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2433 · Cited by 277 · see citing works
Advances in mast cell biology: new understanding of heterogeneity and function
Moon, T. C., Laurent, C. D. S., Morris, K., Marcet, C. T., Yoshimura, T., Sekar, Y., & Befus, A. D. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.136 · Cited by 274 · see citing works
Male and female sex hormones in primary headaches
Delaruelle, Z., Ivanova, T. A., Khan, S., Negro, A., Ornello, R., Raffaelli, B., Terrin, A., Mitsikostas, D. D., & Reuter, U. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0922-7 · Cited by 235 · see citing works
Endocrine Factors Modulating Immune Responses in Pregnancy
Schumacher, A., Costa, S., & Zenclussen, A. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00196 · Cited by 220 · see citing works
Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones
Méleine, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6725 · Cited by 220 · see citing works
Non‐IgE mediated mast cell activation
Redegeld, F. A., Yu, Y., Kumari, S., Charles, N., & Blank, U. (2018) · Immunological Reviews · doi:10.1111/imr.12629 · Cited by 212 · see citing works
The Master Switch: The Role of Mast Cells in Autoimmunity and Tolerance
Sayed, B. A., Christy, A. L., Quirion, M. R., & Brown, M. A. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090320 · Cited by 207 · see citing works
Sex steroids as inflammatory regulators
Gilliver, S. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.015 · Cited by 198 · see citing works
Meta‐analysis: do irritable bowel syndrome symptoms vary between men and women?
Adeyemo, M. A., Spiegel, B. M. R., & Chang, L. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04409.x · Cited by 186 · see citing works
Sex steroid signaling: Implications for lung diseases
Sathish, V., Martin, Y. N., & Prakash, Y. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.01.007 · Cited by 168 · see citing works
Sex differences matter in the gut: effect on mucosal immune activation and inflammation
Sankaran‐Walters, S., Macal, M., Grishina, I., Nagy, L. H., Goulart, L., Coolidge, K., Li, J., Fenton, A. N., Williams, T., Miller, M. K., et al. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-10 · Cited by 160 · see citing works
Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines
Risma, K., Edwards, K. M., Hummell, D. S., Little, F. F., Norton, A. E., Stallings, A. P., Wood, R. A., & Milner, J. D. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.002 · Cited by 152 · see citing works
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Medical treatment for rectovaginal endometriosis: what is the evidence?
Vercellini, P., Crosignani, P. G., Somigliana, E., Berlanda, N., Barbara, G., & Fedele, L. (2009) · Human Reproduction · doi:10.1093/humrep/dep231 · Cited by 144 · see citing works
Gender‐medicine aspects in allergology
Jensen‐Jarolim, E., & Untersmayr, E. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01645.x · Cited by 143 · see citing works
Neuroendocrinology of mast cells: Challenges and controversies
Theoharides, T. C. (2017) · Experimental Dermatology · doi:10.1111/exd.13288 · Cited by 117 · see citing works
Self-citationGender and sex hormones in multiple sclerosis pathology and therapy
Nicot, A. B. (2009) · Frontiers in bioscience · doi:10.2741/3543 · Cited by 94 · see citing works
Mackey, E., Ayyadurai, S., Pohl, C. S., Costa, S. D., Li, Y., & Moeser, A. J. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0113-7 · Cited by 93 · see citing works
The role of mast cells and their mediators in reproduction, pregnancy and labour
Menzies, F. M., Shepherd, M. C., Nibbs, R. J. B., & Nelson, S. M. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq053 · Cited by 87 · see citing works
Kasperska−Zając, A., Brzoza, Z., & Rogala, B. (2008) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2008.04.002 · Cited by 83 · see citing works
de Oliveira, A. P. L., Domingos, H. V., Cavriani, G., Damazo, A. S., dos Santos Franco, A. L., Oliani, S. M., Oliveira-Filho, R. M., Vargaftig, B. B., & de Lima, W. T. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00286.2006 · Cited by 79 · see citing works
Pigrau, M., Rodiño‐Janeiro, B. K., Casado‐Bedmar, M., Lobo, B., Vicario, M., Santos, J., & Alonso, C. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12717 · Cited by 79 · see citing works
The Multitasking Mast Cell: Positive and Negative Roles in the Progression of Autoimmunity
Christy, A. L., & Brown, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.2673 · Cited by 71 · see citing works
Sex-related Differences in Inflammatory Bowel Diseases: The Potential Role of Sex Hormones
Xu, L., Huang, G., Cong, Y., Yu, Y., & Li, Y. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac094 · Cited by 72 · see citing works
How hormones may modulate human skin pigmentation in melasma: An in vitro perspective
Cario, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13915 · Cited by 63 · see citing works
Targeting mast cells: a new way to treat endometriosis
Binda, M. M., Donnez, J., & Dolmans, M. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1260548 · Cited by 59 · see citing works
Adverse reactions to food: the female dominance – A secondary publication and update
Afify, S. M., & Pali‐Schöll, I. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0174-z · Cited by 60 · see citing works
Sex as a biological variable in irritable bowel syndrome
Camilleri, M. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13802 · Cited by 59 · see citing works
Neuroendocrinology of the skin
Theoharides, T. C., Stewart, J. M., Taracanova, A., Conti, P., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9369-9 · Cited by 58 · see citing works
Self-citationSex Hormones and Lung Inflammation
Reyes-García, J., Montaño, L. M., Carbajal-García, A., & Wang, Y.-X. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-68748-9_15 · Cited by 71 · see citing works
Gender-Specific Asthma Treatment
Choi, I. S. (2011) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2011.3.2.74 · Cited by 56 · see citing works
Muñoz-Cruz, S., Mendoza-Rodríguez, Y., Nava-Castro, K. E., Yepez-Mulia, L., & Morales-Montor, J. (2015) · Journal of Immunology Research · doi:10.1155/2015/351829 · Cited by 54 · see citing works
“This is consistent with previous studies reporting that progesterone (100 nM) inhibits histamine secretion from PMCs purified from male rats stimulated immunologically [14].”
Matito, A., Álvarez‐Twöse, I., Morgado, J. M., Sánchez‐Muñoz, L., Orfao, A., & Escribano, L. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000321954 · Cited by 54 · see citing works
Understanding the Biological Relationship between Migraine and Depression
Viudez‐Martínez, A., Torregrosa, A. B., Navarrete, F., & García‐Gutiérrez, M. S. (2024) · Biomolecules · doi:10.3390/biom14020163 · Cited by 55 · see citing works
Drug allergy in children and adults
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Perimenstrual asthma: from pathophysiology to treatment strategies
Graziottin, A., & Serafini, A. (2016) · Multidisciplinary Respiratory Medicine · doi:10.1186/s40248-016-0065-0 · Cited by 58 · see citing works
Sex difference in irritable bowel syndrome: do gonadal hormones play a role?
Mulak, A., & Taché, Y. (2010) · PubMed · Cited by 46 · see citing works
Sex hormones and allergies: exploring the gender differences in immune responses
Gutiérrez-Brito, J. A., Lomelí-Nieto, J. Á., Muñóz-Valle, J. F., Oregon‐Romero, E., Corona-Angeles, J. A., & Hernández‐Bello, J. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2024.1483919 · Cited by 44 · see citing works
Menstrual cycle, sex hormones in female inflammatory bowel disease patients with and without surgery
Bharadwaj, S., Kulkarni, G., & Shen, B. (2015) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12247 · Cited by 42 · see citing works
Hormonal Effects on Asthma, Rhinitis, and Eczema
Weare-Regales, N., Chiarella, S. E., Cardet, J. C., Prakash, Y. S., & Lockey, R. F. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.04.002 · Cited by 40 · see citing works
Chiarella, S. E., Cardet, J. C., & Prakash, Y. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.007 · Cited by 40 · see citing works
Mast cell activation disease and the modern epidemic of chronic inflammatory disease
Afrin, L. B. (2016) · Translational Research · doi:10.1016/j.trsl.2016.01.003 · Cited by 39 · see citing works
FERRARI, S., PERSICO, P., DI PUPPO, F., VIGANO, P., TANDOI, I., GARAVAGLIA, E., GIARDINA, P., MEZZI, G., & CANDIANI, M. (2012) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2012.01366.x · Cited by 38 · see citing works
Allergic Reactions to COVID-19 Vaccines: Risk Factors, Frequency, Mechanisms and Management
Luxi, N., Giovanazzi, A., Arcolacı, A., Bonadonna, P., Crivellaro, M., Cutroneo, P. M., Ferrajolo, C., Furci, F., Guidolin, L., Moretti, U., et al. (2022) · BioDrugs · doi:10.1007/s40259-022-00536-8 · Cited by 37 · see citing works
Gender differences in anaphylaxis
Salvati, L., Vitiello, G., & Parronchi, P. (2019) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000568 · Cited by 38 · see citing works
Fan, Z., Che, H., Yang, S., & Chen, C. (2019) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2019.03.001 · Cited by 35 · see citing works
Asthma and endocrine disorders: Shared mechanisms and genetic pleiotropy
Tesse, R., Schieck, M., & Kabesch, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.032 · Cited by 33 · see citing works
Sex Steroids Effects on Asthma: A Network Perspective of Immune and Airway Cells
Borkar, N. A., Combs, C. K., & Sathish, V. (2022) · Cells · doi:10.3390/cells11142238 · Cited by 29 · see citing works
Weare-Regales, N., Carr, T. F., Holguín, F., Tibbitt, C. A., & Lockey, R. F. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.09.018 · Cited by 27 · see citing works
Exploring the role of sex hormones and gender diversity in multiple sclerosis
Nesbitt, C., van der Walt, A., Butzkueven, H., Cheung, A. S., & Jokubaitis, V. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01042-x · Cited by 23 · see citing works
Hormonal Effects on Urticaria and Angioedema Conditions
Bernstein, J. A., Bouillet, L., Caballero, T., & Staevska, M. T. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.04.021 · Cited by 23 · see citing works
Bauza, D. E. R., & Silveyra, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197270 · Cited by 22 · see citing works
Szukiewicz, D., Wojdasiewicz, P., Wątroba, M., & Szewczyk, G. (2022) · Journal of Immunology Research · doi:10.1155/2022/9534163 · Cited by 22 · see citing works
Genitourinary mast cells and survival.
Theoharides, T. C., & Stewart, J. M. (2015) · PubMed Central · doi:10.3978/j.issn.2223-4683.2015.10.04 · Cited by 21 · see citing works
Self-citationVinnik, T., Kreinin, A., Abildinova, G. Z., Batpenova, G., Kirby, M., & Pinhasov, A. (2020) · Dermatology · doi:10.1159/000504388 · Cited by 20 · see citing works
Gender Specific Pelvic Pain Severity in Neurogenic Cystitis
Rudick, C. N., Павлов, В. И., Chen, M. C., & Klumpp, D. J. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.10.048 · Cited by 18 · see citing works
Exploring the mast cell enigma: a personal reflection of what remains to be done
Henz, B. M. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00658.x · Cited by 18 · see citing works
Mast cell function in physiology and pathophysiology
Gerhard, J. (2010) · Cited by 17 · see citing works
Kaur, S., Hickman, T. M., Lopez-Ramirez, A., McDonald, H., Lockhart, L. M., Darwish, O., & Averitt, D. L. (2022) · Pain · doi:10.1097/j.pain.0000000000002604 · Cited by 17 · see citing works
Mast cell, the peculiar member of the immune system: A homeostatic aspect
Csaba, G. (2015) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/030.62.2015.3.1 · Cited by 17 · see citing works
Mast cells—Good guys with a bad image?
Meyer, N., & Zenclussen, A. C. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13002 · Cited by 17 · see citing works
Sex Differences in Mast Cell–Associated Disorders: A Life Span PerspectivePreprint
Mackey, E. E., & Moeser, A. J. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a039172 · Cited by 17 · see citing works
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McCallion, A., Sisnett, D. J., Zutautas, K. B., Hayati, D., Spiess, K. G., Aleksieva, S., Lingegowda, H., Koti, M., & Tayade, C. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00062 · Cited by 16 · see citing works
Regular exercise modulates cardiac mast cell activation in ovariectomized rats
Phungphong, S., Kijtawornrat, A., Wattanapermpool, J., & Bupha‐Intr, T. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0409-0 · Cited by 15 · see citing works
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Goldstuck, N. D. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109955 · Cited by 14 · see citing works
Mast cell involvement in human cervical ripening
Norström, A., Radulovic, N. V., Bullarbo, M., & Ekerhovd, E. (2019) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2019.05.010 · Cited by 14 · see citing works
Pan, C., Zhang, Y.-S., Han, J., Li, C., Yi, Y., Zhao, Y., Wang, L.-M., Tian, J., Liu, S., Li, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20204988 · Cited by 12 · see citing works
Endogenous inhibitory mechanisms in asthma
Chiarella, S. E., & Barnes, P. J. (2023) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2023.100135 · Cited by 12 · see citing works
Needham, K., Fadia, M., Dahlstrom, J. E., Harrington, K., Shadbolt, B., & Robson, S. (2016) · Journal of Inflammation Research · doi:10.2147/jir.s80722 · Cited by 11 · see citing works
Barreira, J. C. M., & Ferreira, I. C. F. R. (2015) · doi:10.1002/9781118733103.ch16 · Cited by 11 · see citing works
Effect of Gender and Special Considerations for Women in Mastocytosis and Anaphylaxis
Ellingwood, S., & Kovalszki, A. (2023) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2023.04.004 · Cited by 8 · see citing works
Effect of Puberty, Menstruation, Pregnancy, Lactation, and Menopause on Chronic Urticaria Activity
Örnek, S., Alkilinc, A. S., Kızıltaç, U., Kızıltaç, K., & Kocatürk, E. (2023) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/12034754231191472 · Cited by 8 · see citing works
Effect of prolonged use of high dose of tibolone on the vagina of ovariectomized rats
Henriques, H. N., de Carvalho, A. C. B., Filho, P. J. S., Pantaleão, J. A. S., & Guzmán-Silva, M. A. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00774.x · Cited by 8 · see citing works
Mastocytosis and Skin Cancer: The Current State of Knowledge
Kaszuba, A., Sławińska, M., Żółkiewicz, J., Sobjanek, M., Nowicki, R. J., & Lange, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129840 · Cited by 7 · see citing works
Perimenstrual asthma: from pathophysiology to treatment strategies
Graziottin, A., & Serafini, A. (2016) · Multidisciplinary Respiratory Medicine · doi:10.4081/mrm.2016.322 · Cited by 7 · see citing works
Effect of Long-term Hyperimmunization on the Presence of Mast Cells in the Endometrium of the Mare
Witkowski, M., Katkiewicz, M., Zając, S., & Kochan, J. (2015) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2015.03.003 · Cited by 6 · see citing works
Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence
Gettler, K., Nagpal, S., Washburn, S., Tastad, C., Zhang, J., Sabic, K., Lazarev, M. G., Bitton, A., Cohen, R., Schwartz, M. B., et al. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.08.038 · Cited by 4 · see citing works
Joshi, S. R., & Khan, D. A. (2018) · Springer eBooks · doi:10.1007/978-3-030-03395-8_8 · Cited by 4 · see citing works
Terhesség az immunsejtek szemszögéből
Pállinger, É., Nagy, B. M., Király, A., & Fülöp, V. (2023) · Orvosi Hetilap · doi:10.1556/650.2023.32935 · Cited by 4 · see citing works
Frump, A. L., & Lahm, T. (2015) · Respiratory medicine · doi:10.1007/978-3-319-23998-9_2 · Cited by 4 · see citing works
Sex Differences in Oxidative Stress Concerning Allergic Diseases
Cristallo, M., Furci, F., Casciaro, M., Gangemi, S., & Nettis, E. (2025) · Biomolecules · doi:10.3390/biom15101461 · Cited by 4 · see citing works
Nguyen, H. T. G., Le, H. T. T., Việt, N. H., Lê, H. M., Vu, H. L., Inaoka, P. T., Tetsuo, O., Ly, Q. T., & Espinoza, J. L. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14040373 · Cited by 3 · see citing works
Pelzer, E., & Huygens, F. (2016) · Journal of Microbial & Biochemical Technology · doi:10.4172/1948-5948.1000307 · Cited by 2 · see citing works
Bladder pain syndrome and pregnancy
Ivare, A. M., Obloza, A., & Goddard, J. C. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.06.017 · Cited by 2 · see citing works
Lung function tests in different phases of menstrual cycle
Dudhamal, V. B., & Satish, D. M. (2017) · International Journal of Medical Research and Review · doi:10.17511/ijmrr.2017.i08.01 · Cited by 2 · see citing works
Effect of Hormones as Cofactors in Food Allergy
Mir‐Ihara, P., González-Matamala, M. F., Ruano-Zaragoza, M., Loli‐Ausejo, D., Garcia-Garcia, L., Tubita, V., Pascal, M., Martínez‐Zamora, M. Á., Bartra, J., & Muñoz‐Cano, R. (2024) · Current Treatment Options in Allergy · doi:10.1007/s40521-024-00359-8 · Cited by 1 · see citing works
Abd‐Elkareem, M., Alnasser, S. M., Alotaibi, M., Kotob, M. H., Amer, A., Abdullah, R. I., & Ali, A. U. (2025) · Scientific Reports · doi:10.1038/s41598-025-92354-5 · Cited by 1 · see citing works
Mappa, I., Porcaro, G., Derme, M., & RIZZO, G. (2025) · Nutrients · doi:10.3390/nu18010113 · Cited by 1 · see citing works
Sex differences in innate immune cell responses: Impact on cancer immunity and response to therapy
Ramin, S., & Medler, T. R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1864861 · Cited by 1 · see citing works
A Review of the Clinical and Immunologic Effects of Estrogen on Atopic Dermatitis
Murase, J. E. (2015) · Obstetrics & Gynecology International Journal · doi:10.15406/ogij.2015.02.00039 · Cited by 1 · see citing works
Immunodeficiencies, pathogens and sex in upper respiratory diseases
Suvilehto, J. (2009) · Työväentutkimus Vuosikirja
- Authors
- Vasiadi, M., Kempuraj, D., Boucher, W., Kalogeromitros, D., & Theoharides, T. C.
- Affiliations
- Tufts Medical Center (US)
- National and Kapodistrian University of Athens (GR)
- Tufts University (US)
- Corresponding author
- Theoharides, T.C.
- Venue
- International Journal of Immunopathology and Pharmacology
- Publisher
- SAGE Publications
- Published
- 2006-10
- Volume
- 19
- Issue
- 4
- Pages
- 787-794
- ISSN
- 0394-6320 (ISSN-L)
- 2058-7384
- OpenAlex
- W2142403829
- Cited by
- 107
- References
- 42
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Immunopathology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk042409-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42409)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- progesterone, mast cells, histamine release, substance P, estrogen receptor, estradiol, tamoxifen, peritoneal mast cells, pregnancy, inflammatory diseases, irritable bowel syndrome, interstitial cystitis, migraine, allergic reactions
- MeSH terms
- Animals, Male, Mast Cells, Progesterone, Rats, Sprague-Dawley, Rats
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