MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

Richardson, Mark B.; Williams, Spencer J.

doi:10.3389/fimmu.2014.00288

Cited by 139Immune Response and InflammationImmune responses and vaccinationsImmunotherapy and Immune Responses

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

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Richardson, Mark B., Williams, Spencer J.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00288PMC PMC4066366

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Abstract

Macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage-associated and pathogen-associated molecular patterns. In this review, we cover the discovery and molecular characterization of these C-type lectin receptors, and highlight recent advances in the understanding of their roles in orchestrating the response of the immune system to bacterial and fungal infection, and damaged self. We also discuss the identification and structure-activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have significant potential in the development of TH1/TH17 vaccination strategies.

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Direct recognition of apoptotic material by efferocytes involves receptors including CR3, CR4, CD36, CD91, SR-A, vitronectin receptor, αvβ5 integrin, and Mincle, which also recognizes the M. tuberculosis cell wall lipid TDM.
“For direct recognition of apoptotic material by efferocytes an array of receptors, which mediate tethering and/or engulfment, include CR3 and CR4, CD36, CD91 [low density lipoprotein receptor-related protein (LRP)], and other scavenging receptors (SR-A), vitronectin receptor (αvβ3) and αvβ5integrin as well as Mincle, which also recognizes the M. tuberculosis cell wall lipid TDM (134).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [134]

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Authors: Richardson, M. B., & Williams, S. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Williams, Spencer J.
ORCID: Richardson, Mark B.
Williams, Spencer J.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014-06-23
Volume: 5
Pages: 288-288
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00288
PMC: PMC4066366
OpenAlex: W2005183346
Cited by: 138
References: 49
Citations by year: 2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 17 · 2015: 9 · 2014: 1
FWCI: 1.27
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders: Australian Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Mincle, C-type lectin receptors, pattern recognition receptors, damage-associated molecular patterns, pathogen-associated molecular patterns, trehalose dimycolate, mycobacterial glycolipids, bacterial infection, fungal infection, structure-activity relationship, innate immunity

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MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

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