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MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns
Open accessAbstract
Macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage-associated and pathogen-associated molecular patterns. In this review, we cover the discovery and molecular characterization of these C-type lectin receptors, and highlight recent advances in the understanding of their roles in orchestrating the response of the immune system to bacterial and fungal infection, and damaged self. We also discuss the identification and structure-activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have significant potential in the development of TH1/TH17 vaccination strategies.
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“For direct recognition of apoptotic material by efferocytes an array of receptors, which mediate tethering and/or engulfment, include CR3 and CR4, CD36, CD91 [low density lipoprotein receptor-related protein (LRP)], and other scavenging receptors (SR-A), vitronectin receptor (αvβ3) and αvβ5integrin as well as Mincle, which also recognizes the M. tuberculosis cell wall lipid TDM (134).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [134]
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Metadata
- Authors
- Richardson, M. B., & Williams, S. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Williams, Spencer J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-06-23
- Volume
- 5
- Pages
- 288-288
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4066366
- OpenAlex
- W2005183346
- Cited by
- 138
- References
- 49
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 17 · 2015: 9 · 2014: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- Mincle, C-type lectin receptors, pattern recognition receptors, damage-associated molecular patterns, pathogen-associated molecular patterns, trehalose dimycolate, mycobacterial glycolipids, bacterial infection, fungal infection, structure-activity relationship, innate immunity
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