The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
The Role of CD44 in Disease Pathophysiology and Targeted Treatment
Open accessAbstract
The cell-surface glycoprotein CD44 is involved in a multitude of important physiological functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte activation. The diverse physiological activity of CD44 is manifested in the pathology of a number of diseases including cancer, arthritis, bacterial and viral infections, interstitial lung disease, vascular disease, and wound healing. This diversity in biological activity is conferred by both a variety of distinct CD44 isoforms generated through complex alternative splicing, posttranslational modifications (e.g., N- and O-glycosylation), interactions with a number of different ligands, and the abundance and spatial distribution of CD44 on the cell surface. The extracellular matrix glycosaminoglycan hyaluronic acid (HA) is the principle ligand of CD44. This review focuses both CD44-hyaluronan dependent and independent CD44 signaling and the role of CD44-HA interaction in various pathophysiologies. The review also discusses recent advances in novel treatment strategies that exploit the CD44-HA interaction either for direct targeting or for drug delivery.
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Yaşlı Kadınlarda Üreme Sağlığı
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Cited by
Hyaluronan: More than just a wrinkle filler
Maytin, E. V. (2016) · Glycobiology · doi:10.1093/glycob/cww033 · Cited by 128
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García-Sánchez, D., González-González, A., Alfonso-Fernández, A., Del Dujo-Gutiérrez, M., & Pérez-Campo, F. M. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i5.421 · Cited by 32
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Metadata
- Authors
- Jordan, A. R., Racine, R. R., Hennig, M. J. P., & Lokeshwar, V. B.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-04-21
- Volume
- 6
- Pages
- 182-182
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2027741236
- Cited by
- 275
- References
- 125
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
