CoChat
Sign Up
Cited by 68

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

Zhu, Yi, Kruglikov, Ilja L., Akgul, Yucel, Scherer, Philipp E.·2019·Matrix Biology
DOI 10.1016/j.matbio.2018.02.012PMC PMC6534160
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.matbio.2018.02.012

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1. Detection of de novo adipogenesis using AdipoChaser mice. (A) Schematic graph of the AdipoChaser system. Adiponectin-rtTA (Adipoq-rtTA), TRE-Cre and Rosa26-loxP-stop-loxP-lacZ triple transgenic mouse is hereby called the AdipoChaser mouse. It constitutively expresses rtTA in mature adipocytes but only expresses Cre when doxycycline (dox) is supplemented. The Cre will subsequently recombine the loxP sites and remove the stop cassette to allow expression of LacZ. The LacZ expression will persist even after removal of dox. But new adipocytes emerging from non-adiponectin expressing progenitor or stem cells after doxycycline removal will not express LacZ. LacZ reacts with X-gal (5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside) and develops a dark blue color. So existing mature adipocytes will be labeled blue after dox supplementation, and any new adipocytes emerging after removal of dox will not be labeled. (B) Representative β-gal (blue) and Perilipin1 (red) staining of subcutaneous white adipose tissue in AdipoChaser mouse 6 weeks after Juvederm injection. Nuclei are counterstained with DAPI (blue). The circle indicates the boundary of Juvederm and adipose tissue. Scale bar: 250 μm.
Fig. 1. Detection of de novo adipogenesis using AdipoChaser mice. (A) Schematic graph of the AdipoChaser system. Adiponectin-rtTA (Adipoq-rtTA), TRE-Cre and Rosa26-loxP-stop-loxP-lacZ triple transgenic mouse is hereby called the AdipoChaser mouse. It constitutively expresses rtTA in mature adipocytes but only expresses Cre when doxycycline (dox) is supplemented. The Cre will subsequently recombine the loxP sites and remove the stop cassette to allow expression of LacZ. The LacZ expression will persist even after removal of dox. But new adipocytes emerging from non-adiponectin expressing progenitor or stem cells after doxycycline removal will not express LacZ. LacZ reacts with X-gal (5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside) and develops a dark blue color. So existing mature adipocytes will be labeled blue after dox supplementation, and any new adipocytes emerging after removal of dox will not be labeled. (B) Representative β-gal (blue) and Perilipin1 (red) staining of subcutaneous white adipose tissue in AdipoChaser mouse 6 weeks after Juvederm injection. Nuclei are counterstained with DAPI (blue). The circle indicates the boundary of Juvederm and adipose tissue. Scale bar: 250 μm.CC BY-NC-ND · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 69

  1. Prehm, 1990, Release of hyaluronate from eukaryotic cells, Biochem. J., 267, 185, 10.1042/bj2670185 · DOI
  2. Anderegg, 2014, More than just a filler - the role of hyaluronan for skin homeostasis, Exp. Dermatol., 23, 295, 10.1111/exd.12370 · DOI
  3. Schiller, 1957, The metabolism of mucopolysaccharides in animals. IV. The influence of insulin, J. Biol. Chem., 227, 625, 10.1016/S0021-9258(18)70742-4 · DOI
  4. Fraser, 1989, Turnover and metabolism of hyaluronan, CIBA Found. Symp., 143, 41
  5. Fraser, 1984, Elimination of hyaluronic acid from the blood stream in the human, Clin. Exp. Pharmacol. Physiol., 11, 17, 10.1111/j.1440-1681.1984.tb00235.x · DOI
  6. Stern, 2007, The many ways to cleave hyaluronan, Biotechnol. Adv., 25, 537, 10.1016/j.biotechadv.2007.07.001 · DOI
  7. Amarnath, 2006, In vitro hemocompatibility testing of UV-modified hyaluronan hydrogels, Biomaterials, 27, 1416, 10.1016/j.biomaterials.2005.08.008 · DOI
  8. Glogau, 2012, Fillers: from the past to the future, Semin. Cutan. Med. Surg., 31, 78, 10.1016/j.sder.2012.03.004 · DOI
  9. Goodman, 2011, A comparison of the efficacy, safety, and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter, prospective, randomized, controlled, single-blind, within-subject study, Clin. Cosmet. Investig. Dermatol., 4, 197, 10.2147/CCID.S26055 · DOI
  10. Bechara, 2008, Hyaluronic acid new formulation: experience in HIV-associated facial lipoatrophy, Dermatology, 217, 244, 10.1159/000148252 · DOI
  11. Pavicic, 2010, Monophasic, cohesive-polydensified-matrix crosslinking-technology-based hyaluronic acid filler for the treatment of facial lipoatrophy in HIV-infected patients, J. Drugs Dermatol., 9, 690
  12. Elliott, 2010, Hyaluronic acid filler for steroid atrophy, J. Cosmet. Dermatol., 9, 253, 10.1111/j.1473-2165.2010.00508.x · DOI
  13. Philipp-Dormston, 2017, Consensus statement on prevention and management of adverse effects following rejuvenation procedures with hyaluronic acid-based fillers, J. Eur. Acad. Dermatol. Venereol., 31, 1088, 10.1111/jdv.14295 · DOI
  14. Wollina, 2015, Midfacial rejuvenation by hyaluronic acid fillers and subcutaneous adipose tissue—a new concept, Med. Hypotheses, 84, 327, 10.1016/j.mehy.2015.01.023 · DOI
  15. Bertossi, 2013, Hyaluronic acid: in vitro and in vivo analysis, biochemical properties and histological and morphological evaluation of injected filler, Eur. J. Dermatol., 23, 449, 10.1684/ejd.2013.2059 · DOI
  16. Kruglikov, 2015, Soft tissue fillers as non-specific modulators of adipogenesis: change of the paradigm?, Exp. Dermatol., 24, 912, 10.1111/exd.12852 · DOI
  17. Cowman, 2015, The content and size of hyaluronan in biological fluids and tissues, Front. Immunol., 6, 261, 10.3389/fimmu.2015.00261 · DOI
  18. Akgul, 2012, Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth, Endocrinology, 153, 3493, 10.1210/en.2011-1950 · DOI
  19. Han, 2007, Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion, Diabetes, 56, 2260, 10.2337/db07-0218 · DOI
  20. Laurent, 1996, The structure and function of hyaluronan: an overview, Immunol. Cell Biol., 74, A1, 10.1038/icb.1996.32 · DOI
  21. Succar, 2016, Priming adipose-derived mesenchymal stem cells with hyaluronan alters growth kinetics and increases attachment to articular cartilage, Stem Cells Int., 2016, 10.1155/2016/9364213 · DOI
  22. Horkay, 2009, Ions in hyaluronic acid solutions, J. Chem. Phys., 131, 10.1063/1.3262308 · DOI
  23. Guyton, 1971, Interstitial fluid pressure, Physiol. Rev., 51, 527, 10.1152/physrev.1971.51.3.527 · DOI
  24. Cui, 2017, High-salt intake negatively regulates fat deposition in mouse, Sci. Rep., 7, 2053, 10.1038/s41598-017-01560-3 · DOI
  25. Hepler, 2017, Sorting out adipocyte precursors and their role in physiology and disease, Genes Dev., 31, 127, 10.1101/gad.293704.116 · DOI
  26. Vishvanath, 2016, Pdgfrbeta+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice, Cell Metab., 23, 350, 10.1016/j.cmet.2015.10.018 · DOI
  27. Mariman, 2010, Adipocyte extracellular matrix composition, dynamics and role in obesity, Cell. Mol. Life Sci., 67, 1277, 10.1007/s00018-010-0263-4 · DOI
  28. Calvo, 1993, Rheological effects of the presence of hyaluronic acid in the extracellular media of differentiated 3T3-L1 preadipocyte cultures, Arch. Biochem. Biophys., 302, 468, 10.1006/abbi.1993.1241 · DOI
  29. Chen, 2007, Hyaluronan preserves the proliferation and differentiation potentials of long-term cultured murine adipose-derived stromal cells, Biochem. Biophys. Res. Commun., 360, 1, 10.1016/j.bbrc.2007.04.211 · DOI
  30. Ji, 2014, Inhibition of adipogenesis in 3T3-L1 cells and suppression of abdominal fat accumulation in high-fat diet-feeding C57BL/6J mice after downregulation of hyaluronic acid, Int. J. Obes., 38, 1035, 10.1038/ijo.2013.202 · DOI
  31. Lin, 2005, The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species, J. Biol. Chem., 280, 4617, 10.1074/jbc.M411863200 · DOI
  32. Wang, 2014, Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes, J. Biol. Chem., 289, 11410, 10.1074/jbc.M113.541458 · DOI
  33. Day, 2002, Hyaluronan-binding proteins: tying up the giant, J. Biol. Chem., 277, 4585, 10.1074/jbc.R100036200 · DOI · Paper page
  34. Jiang, 2011, Hyaluronan as an immune regulator in human diseases, Physiol. Rev., 91, 221, 10.1152/physrev.00052.2009 · DOI · Paper page
  35. Aruffo, 1990, CD44 is the principal cell surface receptor for hyaluronate, Cell, 61, 1303, 10.1016/0092-8674(90)90694-A · DOI
  36. Lee, 2013, Identification of an adipogenic niche for adipose tissue remodeling and restoration, Cell Metab., 18, 355, 10.1016/j.cmet.2013.08.003 · DOI
  37. Bahrami, 2017, Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis, Integr. Biol. (Camb), 9, 223, 10.1039/C7IB00002B · DOI
  38. Collins, 2013, Hyaluronic acid based scaffolds for tissue engineering--a review, Carbohydr. Polym., 92, 1262, 10.1016/j.carbpol.2012.10.028 · DOI
  39. Allison, 2006, Review. Hyaluronan: a powerful tissue engineering tool, Tissue Eng., 12, 2131, 10.1089/ten.2006.12.2131 · DOI
  40. Davidenko, 2010, Collagen-hyaluronic acid scaffolds for adipose tissue engineering, Acta Biomater., 6, 3957, 10.1016/j.actbio.2010.05.005 · DOI
  41. Borzacchiello, 2007, Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering, Biomaterials, 28, 4399, 10.1016/j.biomaterials.2007.06.007 · DOI
  42. Hemmrich, 2008, Autologous in vivo adipose tissue engineering in hyaluronan-based gels—a pilot study, J. Surg. Res., 144, 82, 10.1016/j.jss.2007.03.017 · DOI
  43. Flynn, 2008, Proliferation and differentiation of adipose-derived stem cells on naturally derived scaffolds, Biomaterials, 29, 1862, 10.1016/j.biomaterials.2007.12.028 · DOI
  44. Piccinno, 2013, Adipose stromal/stem cells assist fat transplantation reducing necrosis and increasing graft performance, Apoptosis, 18, 1274, 10.1007/s10495-013-0878-7 · DOI
  45. Wu, 2012, Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human, Cell, 150, 366, 10.1016/j.cell.2012.05.016 · DOI
  46. Ruan, 2014, O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat, Cell, 159, 306, 10.1016/j.cell.2014.09.010 · DOI · Paper page
  47. Wang, 2013, Tracking adipogenesis during white adipose tissue development, expansion and regeneration, Nat. Med., 19, 1338, 10.1038/nm.3324 · DOI · Paper page
  48. Shao, 2016, Zfp423 maintains white adipocyte identity through suppression of the beige cell thermogenic gene program, Cell Metab., 23, 1167, 10.1016/j.cmet.2016.04.023 · DOI
  49. Tharp, 2015, Bioengineering beige adipose tissue therapeutics, Front. Endocrinol. (Lausanne), 6, 164, 10.3389/fendo.2015.00164 · DOI
  50. Tharp, 2015, Matrix-assisted transplantation of functional beige adipose tissue, Diabetes, 64, 3713, 10.2337/db15-0728 · DOI
  51. Stillaert, 2008, Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds, Biomaterials, 29, 3953, 10.1016/j.biomaterials.2008.06.005 · DOI
  52. Ye, 2015, Impact of tamoxifen on adipocyte lineage tracing: inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase, Mol. Metab., 4, 771, 10.1016/j.molmet.2015.08.004 · DOI
  53. McKee, 1996, Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44, J. Clin. Invest., 98, 2403, 10.1172/JCI119054 · DOI
  54. Takahashi, 2005, Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner, J. Biol. Chem., 280, 24195, 10.1074/jbc.M411913200 · DOI
  55. Kabir, 2014, Chemokine network during adipogenesis in 3T3-L1 cells: differential response between growth and proinflammatory factor in preadipocytes vs. adipocytes, Adipocytes, 3, 97, 10.4161/adip.28110 · DOI
  56. Zhang, 2016, CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment, Nat. Commun., 7
  57. Jo, 2009, Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth, PLoS Comput. Biol., 5, 10.1371/journal.pcbi.1000324 · DOI
  58. Sun, 2011, Adipose tissue remodeling and obesity, J. Clin. Invest., 121, 2094, 10.1172/JCI45887 · DOI · Paper page
  59. Weiss, 2000, Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody, Proc. Natl. Acad. Sci. U. S. A., 97, 285, 10.1073/pnas.97.1.285 · DOI
  60. Suzuki, 2005, Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease, Liver Int., 25, 779, 10.1111/j.1478-3231.2005.01064.x · DOI
  61. Rosenberg, 2004, Serum markers detect the presence of liver fibrosis: a cohort study, Gastroenterology, 127, 1704, 10.1053/j.gastro.2004.08.052 · DOI
  62. Bogdani, 2014, Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis, Diabetes, 63, 2727, 10.2337/db13-1658 · DOI
  63. Morita, 2014, Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes, Biomarkers, 19, 493, 10.3109/1354750X.2014.940502 · DOI
  64. Buse, 2006, Hexosamines, insulin resistance, and the complications of diabetes: current status, Am. J. Physiol. Endocrinol. Metab., 290, E1, 10.1152/ajpendo.00329.2005 · DOI
  65. Wang, 2005, TGF-beta induced hyaluronan synthesis in orbital fibroblasts involves protein kinase C betaII activation in vitro, J. Cell. Biochem., 95, 256, 10.1002/jcb.20405 · DOI
  66. Vigetti, 2012, Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis, J. Biol. Chem., 287, 35544, 10.1074/jbc.M112.402347 · DOI
  67. Vigetti, 2014, Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation, J. Biol. Chem., 289, 28816, 10.1074/jbc.M114.597401 · DOI
  68. Park, 2015, Enzymatic fragments of hyaluronan inhibit adipocyte differentiation in 3T3-L1 pre-adipocytes, Biochem. Biophys. Res. Commun., 467, 623, 10.1016/j.bbrc.2015.10.104 · DOI
  69. Park, 2016, Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice, Biochem. Biophys. Res. Commun., 473, 290, 10.1016/j.bbrc.2016.03.098 · DOI

Cited by

Sorted by citations

See all 68

Metadata

Authors
Zhu, Y., Kruglikov, I. L., Akgul, Y., & Scherer, P. E.
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2019-05
Volume
78-79
Pages
284-291
ISSN
0945-053X
DOI
10.1016/j.matbio.2018.02.012
PMC
PMC6534160
Cited by
68
References
8
Language
en
Licence
Funders
  • National Institutes of Health (P01-AG051459, P01-DK088761, R01-DK099110, R01-DK55758)
  • Cancer Prevention and Research Institute of Texas (CPRIT RP140412, K99-DK114498)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism. https://app.cochat.ai/papers/10.1016/j.matbio.2018.02.012
The paper
Zhu, Y., Kruglikov, I. L., Akgul, Y., & Scherer, P. E. (2019). Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism. Matrix Biology. https://doi.org/10.1016/j.matbio.2018.02.012