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Cited by 269Immune Cell Function and InteractionImmune cells in cancerReproductive System and Pregnancy

Developmental and Functional Control of Natural Killer Cells by Cytokines

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Wu, Yang, Tian, Zhigang, Wei, Haiming·2017·Frontiers in Immunology
DOI 10.3389/fimmu.2017.00930PMC PMC5543290
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Abstract

Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tissues. The development and functions of such NK cells are controlled by various cytokines, such as fms-like tyrosine kinase 3 ligand (FL), kit ligand (KL), interleukin (IL)-3, IL-10, IL-12, IL-18, transforming growth factor-β, and common-γ chain family cytokines, which operate at different stages by regulating distinct signaling pathways. Nevertheless, the specific roles of each cytokine that regulates NK cell development or that shapes different NK cell functions remain unclear. In this review, we attempt to describe the characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells. A comprehensive understanding of the role of cytokines in NK cell development and function will aid the generation of better efficacy for adoptive NK cell treatment.

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  • All CAR-NK clinical trials are at the phase I/II trial stage.

    “All these clinical trials are at the phase I/II trial stage [142].”

    From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [142]

    The section “Improving NK Cell Survival and Function in Clinical Treatments” (page unavailable) identifies two clinical trials using CD19-CAR NK cells. It does not give their phases or state that all CAR-NK trials are at phase I/II. Its separate mention of a Phase I trial concerns an anti-KIR treatment, not CAR-NK cells. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Early clinical trial results have not yet demonstrated consistent efficacy and safety for CAR-NK therapy.

    “At present, the early clinical trial results have not yet demonstrated consistent efficacy and safety.”

    From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [142]

    The section “Improving NK Cell Survival and Function in Clinical Treatments” says CAR-NK cells have been used in clinical trials and that efforts to improve their efficacy are underway. It does not report those trials’ results or assess whether they demonstrated consistent efficacy and safety (searched: CAR-NK clinical trial results, efficacy, safety). No page number is available in our copy. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Wu, Y., Tian, Z., & Wei, H.
Affiliations
University of Science and Technology of China (CN)
Corresponding author
  • Tian, Zhigang
  • Wei, Haiming
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2017-08-04
Volume
8
Pages
930-930
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2017.00930
PMC
PMC5543290
OpenAlex
W2744632602
Cited by
269
References
8
Citations by year
2026: 13 · 2025: 20 · 2024: 25 · 2023: 42 · 2022: 54 · 2021: 41 · 2020: 33 · 2019: 22 · 2018: 17 · 2017: 2
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81330071, 91442202)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
natural killer cells, NK cell development, cytokines, adoptive NK cell therapy, NK cell subsets, cytotoxic NK cells, regulatory NK cells, FMS-like tyrosine kinase 3 ligand, stem cell factor, interleukin-3, IL-10, IL-12, IL-18, TGF-beta, common gamma chain cytokines, NK cell expansion, feeder cells, signaling pathways

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