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Cited by 22Reproductive System and PregnancyPregnancy and preeclampsia studiesImmune Cell Function and Interaction

Two Distinct Myeloid Subsets at the Term Human Fetal-Maternal Interface

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Costa, Maria Laura, Robinette, Michelle L., Bugatti, Mattia, Longtine, Mark S., Colvin, Bryanne N., Lantelme, Erica, Vermi, William, Colonna, Marco +2 more·2017·Frontiers in Immunology
DOI 10.3389/fimmu.2017.01357PMC PMC5662895
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Abstract

During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types. These immune cells play pleiotropic roles, as they control spiral artery remodeling to ensure appropriate blood supply and maintain long-term tolerance to a true allograft; yet, they must be able to mount appropriate immune defenses to pathogens that may threaten the fetus. Whether the same cell type accomplishes all these tasks or if there are dedicated subsets remains controversial. Here, we identify and characterize two distinct subsets of myeloid cells that differ in their pro-inflammatory/regulatory capacity. While one subset predominantly produces the immune-modulating cytokine IL-10, the second subset has superior capacity to secrete pro-inflammatory mediators, such as IL-1β and IL-6. The putative regulatory myeloid cells also express high levels of inhibitory receptors and their ligands, including programmed cell death 1 (PD1) ligands. Importantly, a large fraction of CD8 and CD4 cells in normal term human placenta are PD1 positive, suggesting that the PD1/PD1 ligands axis might be critical to maintain tolerance during pregnancy.

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  • TREM2+ tumor macrophages co-expressed CD68, CD163, CSF1R, and nuclear MAFB; foamy TREM2+ tumor macrophages also co-expressed MITF.

    “TREM2+ tumor macrophages co-expressed CD68, CD163, CSF1R, and nuclear MAFB; foamy TREM2+ tumor macrophages also co-expressed MITF, a transcription factor involved in lysosomal biogenesis that marks a regulatory myeloid subset of human placenta (Costa et al., 2017).”

    From TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy (2020) · cites this paper as Costa et al., 2017

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Authors
Costa, M. L., Robinette, M. L., Bugatti, M., Longtine, M. S., Colvin, B. N., Lantelme, E., Vermi, W., Colonna, M., Nelson, D. M., & Cella, M.
Affiliations
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • Washington University in St. Louis (US)
  • University of Brescia (IT)
Corresponding author
Cella, Marina
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2017-10-25
Volume
8
Pages
1357-1357
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2017.01357
PMC
PMC5662895
OpenAlex
W2766243764
Cited by
22
References
1
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 1
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Funders
National Institutes of Health (RO1CA176695)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Keywords
maternal-fetal interface, IL-10, IL-1β, interleukin-6, inhibitory receptors, natural killer cells, placental macrophages, maternal-fetal immune tolerance, spiral artery remodeling, term placenta

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