The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
C-Reactive Protein in Atherothrombosis and Angiogenesis
Open accessAbstract
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions. This review is focused on discussing the role of CRP in cardiovascular disease, including recent advances on the implication of CRP and its forms specifically on the pathogenesis of atherothrombosis and angiogenesis. Besides its role in the humoral innate immune response, CRP contributes to cardiovascular disease progression by recognizing and binding multiple intrinsic ligands. mCRP is not present in the healthy vessel wall but it becomes detectable in the early stages of atherogenesis and accumulates during the progression of atherosclerosis. CRP inhibits endothelial nitric oxide production and contributes to plaque instability by increasing endothelial cell adhesion molecules expression, by promoting monocyte recruitment into the atheromatous plaque and by enzymatically binding to modified low-density lipoprotein. CRP also contributes to thrombosis, but depending on its form it elicits different actions. Pentameric CRP has no involvement in thrombogenesis, whereas mCRP induces platelet activation and thrombus growth. In addition, mCRP has apparently contradictory pro-angiogenic and anti-angiogenic effects determining tissue remodeling in the atherosclerotic plaque and in infarcted tissues. Overall, CRP contributes to cardiovascular disease by several mechanisms that deserve an in-depth analysis.
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C-reactive protein: a critical update
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Cited by
Research Progress on the Relationship between Atherosclerosis and Inflammation
Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., & Chen, R. (2018) · Biomolecules · doi:10.3390/biom8030080 · Cited by 872
Mechanisms underlying the association between periodontitis and atherosclerotic disease
Schenkein, H. A., Papapanou, P. N., Genco, R., & Sanz, M. (2020) · Periodontology 2000 · doi:10.1111/prd.12304 · Cited by 440
C-reactive protein and implications in rheumatoid arthritis and associated comorbidities
Pope, J. E., & Choy, E. H. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.11.005 · Cited by 320
Abad-Jiménez, Z., López-Domènech, S., Gómez-Abril, S. Á., Periañez-Gómez, D., de Marañón, A. M., Bañuls, C., Morillas, C., Víctor, V. M., & Rocha, M. (2020) · Antioxidants · doi:10.3390/antiox9080734 · Cited by 17
Metadata
- Authors
- Badimon, L., Peña, E., Arderiu, G., Padró, T., Slevin, M., Vilahur, G., & Chiva-Blanch, G.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-02
- Volume
- 9
- Pages
- 430-430
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2789788398
- Cited by
- 323
- References
- 67
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Badimon, L., Peña, E., Arderiu, G., Padró, T., Slevin, M., Vilahur, G., & Chiva-Blanch, G. (2018). C-Reactive Protein in Atherothrombosis and Angiogenesis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2018.00430
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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