The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling
Open accessAbstract
Tumor-derived exosomes are being recognized as essential mediators of intercellular communication between cancer and immune cells. It is well established that bone marrow-derived macrophages (BMDMs) take up tumor-derived exosomes. However, the functional impact of these exosomes on macrophage phenotypes is controversial and not well studied. Here, we show that breast cancer-derived exosomes alter the phenotype of macrophages through the Interleukin 6 (IL-6) receptor beta (glycoprotein 130, gp130)-STAT3 signaling pathway. Addition of breast cancer-derived exosomes to macrophages results in the activation of the IL-6 response pathway, including phosphorylation of the key downstream transcription factor STAT3. Exosomal gp130, which is highly enriched in cancer exosomes, triggers the secretion of IL-6 from BMDMs. Moreover, the exposure of BMDMs to cancer-derived exosomes triggers changes from a conventional towards a polarized phenotype often observed in tumor-associated macrophages. All of these effects can be inhibited through the addition of a gp130 inhibitor to cancer-derived exosomes or by blocking BMDMs exosome uptake. Collectively, this work demonstrates that breast cancer derived-exosomes are capable of inducing IL-6 secretion and a pro-survival phenotype in macrophages, partially via gp130/STAT3 signaling.
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Cites
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BackgroundCurrent knowledge on exosome biogenesis and release
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Cited by
IL-6 in inflammation, autoimmunity and cancer
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“Breast cancer-derived exosomes that contain gp130 induce IL-6 production and activate gp130–STAT3 signaling to induce phenotypic changes in bone marrow-derived macrophages toward M2 macrophages (217).”
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Metadata
- Authors
- Ham, S., Lima, L. G., Chai, E. P. Z., Muller, A., Lobb, R. J., Krumeich, S., Wen, S. W., Wiegmans, A. P., & Möller, A.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-05-08
- Volume
- 9
- Pages
- 871-871
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2800494230
- Cited by
- 189
- References
- 11
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ham, S., Lima, L. G., Chai, E. P. Z., Muller, A., Lobb, R. J., Krumeich, S., Wen, S. W., Wiegmans, A. P., & Möller, A. (2018). Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2018.00871
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