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Cited by 42T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

Origin and Evolution of Dendritic Epidermal T Cells

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Sutoh, Yoichi, Mohamed, Rania Hassan, Kasahara, Masanori·2018·Frontiers in Immunology
DOI 10.3389/fimmu.2018.01059PMC PMC5960712
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Abstract

Dendritic epidermal T cells (DETCs) expressing invariant Vγ5Vδ1 T-cell receptors play a crucial role in maintaining skin homeostasis in mice. When activated, they secrete cytokines, which recruit various immune cells to sites of infection and promote wound healing. Recently, a member of the butyrophilin family, Skint1, expressed specifically in the skin and thymus was identified as a gene required for DETC development in mice. Skint1 is a gene that arose by rodent-specific gene duplication. Consequently, a gene orthologous to mouse Skint1 exists only in rodents, indicating that Skint1-dependent DETCs are unique to rodents. However, dendritic-shaped epidermal γδ T cells with limited antigen receptor diversity appear to occur in other mammals. Even lampreys, a member of the most primitive class of vertebrates that even lacks T-cell receptors, have γδ T-like lymphocytes that resemble DETCs. This indicates that species as divergent as mice and lampreys share the needs to have innate-like T cells at their body surface, and that the origin of DETC-like cells is as ancient as that of lymphocytes.

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  • SKINT1, a mouse-specific member of the butyrophilins (BTNs) family that is exclusively expressed in the thymic epithelium and the epidermis, was shown to be essential for thymic selection and skin-specific homing of Vγ5Vγ1 T cell.

    “SKINT1, a mouse-specific member of the butyrophilins (BTNs) family that is exclusively expressed in the thymic epithelium and the epidermis, was shown to be essential for thymic selection and skin-specific homing of Vγ5Vγ1 T cell (32).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [32]

    The “SKINT1 and the SKINT Gene Family” section supports SKINT1’s expression in thymic epithelial cells and skin keratinocytes, and its role in thymic selection and production of cells migrating to the epidermis. But the paper identifies those cells as Vγ5Vδ1, not Vγ5Vγ1, and attributes impaired epidermal migration to defective thymic selection rather than establishing a separate skin-specific homing function. The “Evolution of the SKINT Gene Family” section also says authentic Skint1 genes occur in murids, not only mice. No page numbers are provided for these passages. (LLM, conf=0.88)

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Cited by

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Authors
Sutoh, Y., Mohamed, R. H., & Kasahara, M.
Affiliations
  • Ain Shams University (EG)
  • Hokkaido University (JP)
Corresponding author
Kasahara, Masanori
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2018-05-14
Volume
9
Pages
1059-1059
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2018.01059
PMC
PMC5960712
OpenAlex
W2801518920
Cited by
42
References
3
Citations by year
2026: 2 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 4
FWCI
0.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
dendritic epidermal T cells, butyrophilin, γδ T cells, skin homeostasis, gene duplication, innate-like T cells, thymus, wound healing
MeSH terms
Butyrophilins, Animals, Cell Differentiation, Multigene Family, Humans, Immunoglobulins, Langerhans Cells, Mammals, Biomarkers, T-Lymphocyte Subsets, Evolution, Molecular

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