Cited by 1,450S100 Proteins and AnnexinsBiomarkers in Disease MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

S100A8/A9 in Inflammation

Open access

Wang, Siwen, Song, Rui, Wang, Ziyi, Jing, Zhaocheng, Wang, Shaoxiong, Ma, Jian·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.01298PMC PMC6004386

Open this paper in CoChat — free account Open PDF

Abstract

S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2018.01298

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×
“S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Background
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857
Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484
S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
Damo, S. M., Kehl-Fie, T. E., Sugitani, N., Holt, M. E., Rathi, S., Murphy, W. J., Zhang, Y., Betz, C., Hench, L., Fritz, G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220341110 · Cited by 388
Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
van der Heijden, I. M., Wilbrink, B., Tchetverikov, I., Schrijver, I. A., Schouls, L. M., Hazenberg, M. P., Breedveld, F. C., & Tak, P. P. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200003)43:3 · Cited by 375
β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.004 · Cited by 370
Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
Björk, P., Björk, A., Vogl, T., Stenström, M., Liberg, D., OLSSON, A. G., Roth, J., Ivars, F., & Leanderson, T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000097 · Cited by 357
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I. S., Reichelt, R., Foell, D., Gerke, V., Manitz, M. P., Nacken, W. K. F., et al. (2004) · Blood · doi:10.1182/blood-2004-02-0446 · Cited by 354
Inflammation-associated S100 proteins: new mechanisms that regulate function
Goyette, J., & Geczy, C. L. (2010) · Amino Acids · doi:10.1007/s00726-010-0528-0 · Cited by 354
Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events
Healy, A. M., Pickard, M. D., Pradhan, A. D., Wang, Y., Chen, Z., Croce, K., Sakuma, M., Shi, C., Zago, A. C., Garasic, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.607333 · Cited by 336
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
Viemann, D., Strey, A., Janning, A., Jurk, K., Klimmek, K., Vogl, T., Hirono, K., Ichida, F., Foell, D., Kehrel, B. E., et al. (2004) · Blood · doi:10.1182/blood-2004-07-2520 · Cited by 316
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
Ghavami, S., Rashedi, I., Dattilo, B. M., Eshraghi, M., Chazin, W., Hashemi, M. M., Wesselborg, S., Kerkhoff, C., & Łoś, M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607397 · Cited by 312
S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease
Șchiopu, A., & Cotoi, O. S. (2013) · Mediators of Inflammation · doi:10.1155/2013/828354 · Cited by 273
S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis
Gopal, R., Monin, L., Torres‐García, D., Slight-Webb, S. R., Mehra, S., McKenna, K. C., Junecko, B. A. F., Reinhart, T. A., Kolls, J. K., Báez-Saldaña, R., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0803oc · Cited by 266
Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury
Croce, K., Gao, H., Wang, Y., Mooroka, T., Sakuma, M., Shi, C., Sukhova, G. K., Packard, R. R. S., Hogg, N., Libby, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.814582 · Cited by 254
S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3
Schönthaler, H. B., Guinea‐Viniegra, J., Wculek, S. K., Ruppen, I., Ximénez‐Embún, P., Guío-Carrión, A., Navarro, R., Hogg, N., Ashman, K., & Wagner, E. F. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.011 · Cited by 248
Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa
Lima, Á. L. M., Karl, I., Giner, T., Poppe, H., Schmidt, M., Presser, D., Goebeler, M., & Bauer, B. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14214 · Cited by 233
The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes
Thorey, I. S., Roth, J., Regenbogen, J., Halle, J.-P., Bittner, M., Vogl, T., Kaesler, S., Bugnon, P., Reitmaier, B., Durka, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104871200 · Cited by 233
MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner
Roth, J., BURWINKEL, F., van den Bos, C., Goebeler, M., Vollmer, E., & Sorg, C. (1993) · Blood · doi:10.1182/blood.v82.6.1875.1875 · Cited by 233
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
Polman, C. H., Barkhof, F., Sandberg‐Wollheim, M., Linde, A., Nordle, Ö., & Nederman, T. (2005) · Neurology · doi:10.1212/01.wnl.0000154520.48391.69 · Cited by 227
Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes
Kraakman, M. J., Lee, M. K. S., Al‐Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92450 · Cited by 222
Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer’s disease
Kamphuis, W., Kooijman, L., Schetters, S., Orre, M., & Hol, E. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.007 · Cited by 209
Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes
Altwegg, L., Neidhart, M., Hersberger, M., Muller, S., Eberli, F. R., Corti, R., Roffi, M., Sütsch, G., Gay, S., von Eckardstein, A., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm078 · Cited by 199
DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway
Tsai, S.-Y., Segovia, J. A., Chang, T.-H., Morris, I. R., Berton, M. T., Tessier, P. A., Tardif, M. R., Césaro, A., & Bose, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003848 · Cited by 198
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
Ma, L., Sun, P., Zhang, J.-C., Zhang, Q., & Yao, S.-L. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2987 · Cited by 196 · cited 1×
“In BV-2 microglia, S100A8/A9 stimulates the production of TNF-α and IL-6 through ERK/NF-κB and JNK/ NF-κB signaling (72).”
Background
Calcium-dependent Tetramer Formation of S100A8 and S100A9 is Essential for Biological Activity
Leukert, N., Vogl, T., Strupat, K., Reichelt, R., Sorg, C., & Roth, J. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.04.009 · Cited by 195
Calprotectin in rheumatic diseases
Ometto, F., Friso, L., Astorri, D., Botsios, C., Raffeiner, B., Punzi, L., & Doria, A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681551 · Cited by 185
The arachidonic acid‐binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67 phox and Rac‐2
Kerkhoff, C., Nacken, W. K. F., Benedyk‐Machaczka, M., Dagher, M., Sopalla, C., & Doussière, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2377fje · Cited by 182
Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion
Pruenster, M., Kurz, A. R. M., Chung, K., Cao-Ehlker, X., Bieber, S., Nußbaum, C., Bierschenk, S., Eggersmann, T. K., Rohwedder, I., Heinig, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7915 · Cited by 176
The Two Calcium-binding Proteins, S100A8 and S100A9, Are Involved in the Metabolism of Arachidonic acid in Human Neutrophils
Kerkhoff, C., Klempt, M., Kaever, V., & Sorg, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32672 · Cited by 165
Oxidative modifications of S100 proteins: functional regulation by redox
Lim, S. Y., Raftery, M. J., Goyette, J., Hsu, K., & Geczy, C. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008608 · Cited by 161
Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
Ghavami, S., Kerkhoff, C., Łoś, M., Hashemi, M. M., Sorg, C., & Karami‐Tehrani, F. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903435 · Cited by 160
The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade
Wang, C., Klechikov, A. G., Gharibyan, A. L., Wärmländer, S. K. T. S., Jarvet, J., Zhao, L., Jia, X., Shankar, S. K., Olofsson, A., Brännström, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1208-4 · Cited by 154
In vitro candidastatic properties of the human neutrophil calprotectin complex.
Murthy, A. R., Lehrer, R. I., Harwig, S. S. L., & Miyasaki, K. T. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.11.6291 · Cited by 150
Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications
Boyapati, R. K., Rossi, A. G., Satsangi, J., & Ho, G. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.14 · Cited by 150
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection
Clark, H. L., Jhingran, A., Sun, Y., Vareechon, C., de Jesus Carrion, S., Skaar, E. P., Chazin, W. J., Calera, J. A., Hohl, T. M., & Pearlman, E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502037 · Cited by 149
Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10
Lackmann, M., Rajasekariah, P., Iismaa, S. E., Jones, G. L., Cornish, C. J., Hu, S., Simpson, R. J., Moritz, R. L., & Geczy, C. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2981 · Cited by 147
Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis
Wang, Y., Fang, C., Gao, H., Bilodeau, M. L., Zhang, Z., Croce, K., Liu, S., Morooka, T., Sakuma, M., Nakajima, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70966 · Cited by 146
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4
Laouedj, M., Tardif, M. R., Gil, L., Raquil, M.-A., Lachhab, A., Pelletier, M., Tessier, P. A., & Barabé, F. (2017) · Blood · doi:10.1182/blood-2016-09-738005 · Cited by 142
Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia
Raquil, M.-A., Anceriz, N., Rouleau, P., & Tessier, P. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3366 · Cited by 138
The Zinc-Reversible Antimicrobial Activity of Neutrophil Lysates and Abscess Fluid Supernatants
Sohnle, P. G., Collins-Lech, C., & Wiessner, J. H. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/164.1.137 · Cited by 135
Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis
Achouiti, A., Vogl, T., Urban, C. F., Röhm, M., Hommes, T. J., van Zoelen, M. A. D., Florquin, S., Roth, J., van 't Veer, C., de Vos, A. F., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002987 · Cited by 135
S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo
Chen, B., Miller, A. L., Rebelatto, M. C., Brewah, Y. A., Rowe, D. C., Clarke, L., Czapiga, M., Rosenthal, K., Imamichi, T., Chen, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115828 · Cited by 131
Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis
van Zoelen, M. A. D., Vogl, T., Foell, D., van Veen, S. Q., van Till, J. W. O., Florquin, S., Tanck, M. W. T., Wittebole, X., Laterre, P., Boermeester, M. A., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1552oc · Cited by 131
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR‐215757), a new quinoline‐3‐carboxamide derivative: Studies in lupus‐prone mice and a multicenter, randomized, double‐blind, placebo‐controlled, repeat‐dose, dose‐ranging study in patients with systemic lupus erythematosus
Bengtsson, A. A., Sturfelt, G. K., Lood, C., Rönnblom, L., van Vollenhoven, R., Axelsson, B., Sparre, B., Tuvesson, H., Öhman, M. W., & Leanderson, T. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33493 · Cited by 130
Gene Expression Profiling Reveals Distinct Molecular Signatures Associated With the Rupture of Intracranial Aneurysm
Nakaoka, H., Tajima, A., Yoneyama, T., Hosomichi, K., Kasuya, H., Mizutani, T., & Inoue, I. (2014) · Stroke · doi:10.1161/strokeaha.114.005851 · Cited by 128
Increased perivascular synovial membrane expression of myeloid‐related proteins in psoriatic arthritis
Kane, D. J., Roth, J., Frosch, M., Vogl, T., Bresnihan, B., & FitzGerald, O. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10988 · Cited by 126
Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation
Swindell, W. R., Johnston, A., Xing, X., Little, A., Robichaud, P., Voorhees, J. J., Fisher, G., & Gudjonsson, J. E. (2013) · Scientific Reports · doi:10.1038/srep01215 · Cited by 124
Phagocyte-specific S100A8/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus
Soyfoo, M. S., Roth, J., Vogl, T. J., Pochet, R., & Decaux, G. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081302 · Cited by 123
Differential expression and response to anti‐TNFα treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis
Rycke, L. D., Baeten, D., Foell, D., Kruithof, E., VEYS, E. M., Roth, J., & Keyser, F. D. (2005) · The Journal of Pathology · doi:10.1002/path.1758 · Cited by 123
Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
Austermann, J., Friesenhagen, J., Fassl, S. K., Ortkras, T., Burgmann, J., Barczyk‐Kahlert, K., Faist, E., Zedler, S., Pirr, S. M., Rohde, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.020 · Cited by 122
Calprotectin — A Novel Marker of Obesity
Mortensen, O. H., Nielsen, A. R., Erikstrup, C., Plomgaard, P., Fischer, C. P., Krogh‐Madsen, R., Lindegaard, B., Petersen, A. M. W., Taudorf, S., & Pedersen, B. K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007419 · Cited by 118
An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis
Césaro, A., Anceriz, N., Plante, A., Pagé, N., Tardif, M. R., & Tessier, P. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045478 · Cited by 116
Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin
Bouma, G., Lam‐Tse, W., Wierenga‐Wolf, A. F., Drexhage, H. A., & Versnel, M. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1979 · Cited by 113
S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway
Lu, S., Yu, C., Liu, Y.-H., Dong, H., Zhang, X., Zhang, S., Hu, L., Zhang, F., Qian, Y., & Gui, B. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.10.011 · Cited by 106
Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton
van den Bos, C., Roth, J., Koch, H., Hartmann, M., & Sorg, C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1247 · Cited by 105
The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway
Yano, J., Kolls, J. K., Happel, K. I., Wormley, F. L., Wozniak, K. L., & Fidel, P. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046311 · Cited by 105
Damage-Associated Molecular Pattern S100A9 Increases Bactericidal Activity of Human Neutrophils by Enhancing Phagocytosis
Simard, J.-C., Simon, M.-M., Tessier, P. A., & Girard, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002956 · Cited by 104
HaCaT Keratinocytes Overexpressing the S100 Proteins S100A8 and S100A9 Show Increased NADPH Oxidase and NF-κB Activities
Benedyk‐Machaczka, M., Sopalla, C., Nacken, W. K. F., Bode, G., Melkonyan, H., Bánfi, B., & Kerkhoff, C. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700820 · Cited by 103
Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets
Rosenberg, J. H., Rai, V., Dilisio, M. F., & Agrawal, D. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3047-4 · Cited by 103
Gene profiling in human blood leucocytes during recovery from septic shock
Payen, D. M., Lukaszewicz, A., Bélikova, I., Faivre, V., Gélin, C., Rußwurm, S., Launay, J., & Sévenet, N. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1048-1 · Cited by 95
Modulation of Gene Expression Induced in Human Epidermis by Environmental Stress In Vivo
Bernerd, F., Compan, D., Bernard, B. A., Leclaire, J., Medaisko, C., Méhul, B., Seité, S., Marionnet, C., Dumas, A., Verrecchia, F., et al. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12629.x · Cited by 94
Induction of apoptotic cell death in mouse lymphoma and human leukemia cell lines by a calcium-binding protein complex, calprotectin, derived from inflammatory peritoneal exudate cells
Yui, S., Mikami, M., & Yamazaki, M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.6.650 · Cited by 92
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9
Low, D., Subramaniam, R., Li, L., Aomatsu, T., Mizoguchi, A., Ng, A., DeGruttola, A. K., Lee, C. G., Elias, J. A., Andoh, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5440 · Cited by 92
Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice
Zhang, X., Wei, L., Wang, J., Qin, Z., Wang, J., Lu, Y., Zheng, X., Qiu, P., Ye, Q., Ai, F., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01774 · Cited by 92
Self-citation
Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filaments
Goebeler, M., Roth, J., van den Bos, C., Ader, G., & Sorg, C. (1995) · Biochemical Journal · doi:10.1042/bj3090419 · Cited by 91
S100A8/A9 as a biomarker for synovial inflammation and joint damage in patients with rheumatoid arthritis
Kang, K. Y., Woo, J., & Park, S. (2014) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2014.29.1.12 · Cited by 85
Low dose linomide in Type I juvenile diabetes of recent onset: a randomised placebo-controlled double blind trial
Coutant, R., Landais, P., Rosilio, M., Johnsen, C., Lahlou, N., Chatelain, P., Carel, J., Ludvigsson, J., Boîtard, C., & Bougneres, P. F. (1998) · Diabetologia · doi:10.1007/s001250051028 · Cited by 83
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
van den Bosch, M. H., Blom, A. B., Schelbergen, R. F. P., Koenders, M. I., van de Loo, F. A. J., van den Berg, W. B., Vogl, T., Roth, J., van der Kraan, P. M., & van Lent, P. L. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.160270 · Cited by 81
Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro.
Devery, J. M., King, N. J. C., & Geczy, C. L. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1888 · Cited by 79
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation
Lorey, M. B., Rossi, K., Eklund, K. K., Nyman, T. A., & Matikainen, S. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.064840 · Cited by 78
Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study
Poitou, C., Perret, C., Mathieu, F., Trương, V., Blum, Y., Durand, H., Alili, R., Chelghoum, N., Pelloux, V., Aron‐Wisnewsky, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125718 · Cited by 77
S-Calprotectin (S100A8/S100A9): A Potential Marker of Inflammation in Patients with Psoriatic Arthritis
Hansson, C., Eriksson, C., & Alenius, G.-M. (2014) · Journal of Immunology Research · doi:10.1155/2014/696415 · Cited by 76
Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology
Shen, L., Liao, L., Chen, C., Guo, Y. C., Song, D., Wang, Y., Chen, Y., Zhang, K., Ying, M., Li, S., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160913 · Cited by 76
Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model
Tang, A., Li, N., Li, X., Yang, H., Wang, W., Zhang, L., Li, G., Xiong, W., Ma, J., & Shen, S. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs183 · Cited by 73
Self-citation
Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus
Tydén, H., Lood, C., Gullstrand, B., Jönsen, A., Ivars, F., Leanderson, T., & Bengtsson, A. A. (2016) · Lupus · doi:10.1177/0961203316655208 · Cited by 73
Calprotectin Induces IL‐6 and MCP‐1 Production via Toll‐Like Receptor 4 Signaling in Human Gingival Fibroblasts
Nishikawa, Y., Kajiura, Y., Lew, J. H., Kido, J., Nagata, T., & Naruishi, K. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25724 · Cited by 73
Myeloid‐Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal–Induced Inflammation in Gout
Holzinger, D., Nippe, N., Vogl, T., Marketon, K., Mysore, V., Weinhage, T., Dalbeth, N., Pool, B., Merriman, T. R., Baeten, D., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38369 · Cited by 72
Mrp14 Deficiency Ameliorates Amyloid β Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing
Kummer, M. P., Vogl, T., Axt, D., Griep, A., Vieira-Saecker, A. M. M., Jessen, F., Gelpí, E., Roth, J., & Heneka, M. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-12.2012 · Cited by 72
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
Nordal, H. H., Brokstad, K. A., Solheim, M. H., Halse, A., Kvien, T. K., & Hammer, H. B. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1201-0 · Cited by 72
Calprotectin S100A9 Calcium-binding Loops I and II Are Essential for Keratinocyte Resistance to Bacterial Invasion
Champaiboon, C., Sappington, K. J., Guenther, B. D., Ross, K. F., & Herzberg, M. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806605200 · Cited by 71
Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer’s Disease
Horváth, I., Jia, X., Johansson, P., Wang, C., Moskalenko, R., Steinau, A., Forsgren, L., Wågberg, T., Svensson, J., Zetterberg, H., et al. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00265 · Cited by 71
Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis
Martel, B. C., Litman, T., Hald, A., Norsgaard, H., Lovato, P., Dyring‐Andersen, B., Skov, L., Thestrup‐Pedersen, K., Skov, S., Skak, K., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.12967 · Cited by 71
Growth-inhibitory and apoptosis-inducing activities of calprotectin derived from inflammatory exudate cells on normal fibroblasts: regulation by metal ions
Yui, S., Mikami, M., Tsurumaki, K., & Yamazaki, M. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.61.1.50 · Cited by 71
S100A8 Modulates Mast Cell Function and Suppresses Eosinophil Migration in Acute Asthma
Zhao, J., Endoh, I., Hsu, K., Tedla, N. T., Endoh, Y., & Geczy, C. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3583 · Cited by 70
Zinc binding reverses the calcium‐induced arachidonic acid‐binding capacity of the S100A8/A9 protein complex
Kerkhoff, C., Vogl, T., Nacken, W. K. F., Sopalla, C., & Sorg, C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01322-8 · Cited by 70
Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients
Pouwels, S. D., Nawijn, M. C., Bathoorn, E., Riezebos‐Brilman, A., van Oosterhout, A. J. M., Kerstjens, H. A. M., & Heijink, I. H. (2015) · European Respiratory Journal · doi:10.1183/09031936.00158414 · Cited by 70
Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model
Lee, T.-H., Chang, H. S., Bae, D.-J., Song, H. J., Kim, M.-S., Park, J., Jun, J. A., Lee, S. Y., Uh, S. T., Kim, S. H., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.08.013 · Cited by 66
Purification and characterization of the cytotoxic factor in rat peritoneal exudate cells: its identification as the calcium binding protein complex, calprotectin
Yui, S., Mikami, M., & Yamazaki, M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.3.307 · Cited by 65
Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells byZinc Ion and Its Implication for Apoptosis‐Inducing Activity
Nakatani, Y., Yamazaki, M., Chazin, W., & Yui, S. (2005) · Mediators of Inflammation · doi:10.1155/mi.2005.280 · Cited by 64
S100A8 Induces IL-10 and Protects against Acute Lung Injury
Hiroshima, Y., Hsu, K., Tedla, N. T., Chung, Y. M., Chow, S., Herbert, C. A., & Geczy, C. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302556 · Cited by 63
MRP14 (S100A9) Protein Interacts with Alzheimer Beta-Amyloid Peptide and Induces Its Fibrillization
Zhang, C., Liu, Y., Gilthorpe, J. D., & van der Maarel, J. R. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032953 · Cited by 61
Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns
Buhimschi, C. S., Bhandari, V., Dulay, A. T., Nayeri, U. A., Abdel‐Razeq, S. S., Pettker, C. M., Thung, S., Zhao, G., Han, Y. W., Bizzarro, M. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026111 · Cited by 60
Beneficial effects of quinoline-3-carboxamide (ABR-215757) on atherosclerotic plaque morphology in S100A12 transgenic ApoE null mice
Yan, L., Björk, P., Butuc, R., Gawdzik, J. C., Earley, J. U., Kim, G. H., & Bowman, M. A. H. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.023 · Cited by 60
Diagnostic and prognostic value of myeloid-related protein complex 8/14 for sepsis
Gao, S., Yang, Y., Fu, Y., Guo, W., & Liu, G. (2015) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2015.06.025 · Cited by 58
Injury‐induced MRP8/MRP14 stimulates IP‐10/CXCL10 in monocytes/macrophages
Wang, J., Yoram Vodovotz, B., Fan, L., Li, Y., Liu, Z., Namas, R. A., Barclay, D. A., Zamora, R., Billiar, T. R., Wilson, M. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-255992 · Cited by 58
Inflammation‐induced S100A8 activates I d3 and promotes colorectal tumorigenesis
Zhang, X., Ai, F., Li, X., She, X., Li, N., Tang, A., Qin, Z., Ye, Q., Tian, L., Li, G., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29671 · Cited by 57
Self-citation
Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes
Zaia, A. A., Sappington, K. J., Nisapakultorn, K., Chazin, W., Dietrich, E. A., Ross, K. F., & Herzberg, M. C. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.63 · Cited by 57
Suppression of Inflammation in Rat Autoimmune Myocarditis by S100A8/A9 Through Modulation of the Proinflammatory Cytokine Network
Otsuka, K., Terasaki, F., Ikemoto, M., Fujita, S., Tsukada, B., Katashima, T., Kanzaki, Y., Sohmiya, K., Kono, T., Toko, H., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn049 · Cited by 56
MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
Lee, D., Woo, J., Kwok, S., Cho, M., & Park, S. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.39 · Cited by 56
HIV-1 Transcription and Virus Production Are Both Accentuated by the Proinflammatory Myeloid-Related Proteins in Human CD4+ T Lymphocytes
Ryckman, C., Robichaud, G. A., Roy, J., Cantin, R., Tremblay, M. J., & Tessier, P. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3307 · Cited by 56
The Expression of Inflammatory Genes Is Upregulated in Peripheral Blood of Patients With Type 1 Diabetes
Jin, Y., Sharma, A. K., Carey, C., Hopkins, D., Wang, X., Robertson, D. G., Bode, B. W., Anderson, S. W., Reed, J. H. C., Steed, R. D., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1986 · Cited by 55
Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions
Lodeiro, M., Puerta, E., Ismail, M.-A.-M., Rodriguez‐Rodriguez, P., Rönnbäck, A., Codita, A., Parrado‐Fernández, C., Maioli, S., Gil-Bea, F. J., Merino‐Serrais, P., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw073 · Cited by 55
Calprotectin in rheumatic diseases: a review
Kopeć-Mędrek, M., Widuchowska, M., & Kucharz, E. J. (2016) · Reumatologia/Rheumatology · doi:10.5114/reum.2016.64907 · Cited by 55
Visualized macrophage dynamics and significance of S100A8 in obese fat
Sekimoto, R., Fukuda, S., Maeda, N., Tsushima, Y., Matsuda, K., Mori, T., Nakatsuji, H., Nishizawa, H., Kishida, K., Kikuta, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409480112 · Cited by 54
A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia
Filippo, K. D., Neill, D. R., Mathies, M., Bangert, M., McNeill, E., Kadioglu, A., & Hogg, N. (2014) · The FASEB Journal · doi:10.1096/fj.13-247460 · Cited by 54
2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue
Oliva, K., Barker, G., Rice, G. E., Bailey, M. J., & Lappas, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0010 · Cited by 54
The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout
Chang, K., Kim, H. J., & Suh, Y. (2012) · Neurodegenerative Diseases · doi:10.1159/000333781 · Cited by 53
Role of inflammasome activation in development and exacerbation of asthma
Lee, T.-H., Song, H. J., & Park, C. (2014) · Asia Pacific Allergy · doi:10.5415/apallergy.2014.4.4.187 · Cited by 49
DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes
Sakaguchi, M., Murata, H., Aoyama, Y., Hibino, T., Putranto, E. W., Ruma, I. M. W., Inoue, Y., Sakaguchi, Y. M., Yamamoto, K.-I., Kinoshita, R., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573071 · Cited by 48
Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Nistala, K., Varsani, H., Wittkowski, H., Vogl, T., Król, P., Shah, V., Mamchaoui, K., Brogan, P. A., Roth, J., & Wedderburn, L. R. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4311 · Cited by 48
S100-alarmins: potential therapeutic targets for arthritis
Austermann, J., Zenker, S., & Roth, J. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1330411 · Cited by 47
Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein
Lorenzo, B. H. P. D., Godoy, L. C., Brito, R. R. N. E., Pagano, R. L., Amorim-Dias, M. A., Grosso, D. M., Lopes, J. D., & Mariano, M. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.013 · Cited by 46
Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes
Yonekawa, K., Neidhart, M., Altwegg, L. A., Wyss, C. A., Corti, R., Vogl, T., Grigorian, M., Gay, S., Lüscher, T. F., & Maier, W. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.020 · Cited by 46
Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint
Rosenberg, J. H., Rai, V., Dilisio, M. F., Sekundiak, T. D., & Agrawal, D. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3078-x · Cited by 45
Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways
Coveney, A., Wang, W., Kelly, J., Liu, J. H., Blankson, S., Wu, Q. D., Redmond, H. P., & Wang, J. H. (2015) · Scientific Reports · doi:10.1038/srep13694 · Cited by 44
Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation
Dapunt, U., Giese, T., Maurer, S., Stegmaier, S., Prior, B., Hänsch, G. M., & Gaida, M. M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3vma1014-482r · Cited by 43
The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice
Sun, Y., Lu, Y., Engeland, C. G., Gordon, S. C., & Sroussi, H. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.10.002 · Cited by 43
IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion
Sorenson, B. S., Khammanivong, A., Guenther, B. D., Ross, K. F., & Herzberg, M. C. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.48 · Cited by 42
The Role of Proteomics in the Diagnosis of Chorioamnionitis and Early-Onset Neonatal Sepsis
Buhimschi, I. A., & Buhimschi, C. S. (2010) · Clinics in Perinatology · doi:10.1016/j.clp.2010.03.002 · Cited by 42
Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
Burkhardt, K., Schwarz, S., Pan, C., Stelter, F., Kotliar, K. E., Eynatten, M. V., Sollinger, D., Lanzl, I. M., Heemann, U. W., & Baumann, M. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-10 · Cited by 40
New ELISA System for Myeloid-related Protein Complex (MRP8/14) and Its Clinical Significance as a Sensitive Marker for Inflammatory Responses Associated with Transplant Rejection
Ikemoto, M., Tanaka, T., Takai, Y., Murayama, H., Tanaka, K., & Fujita, M. (2003) · Clinical Chemistry · doi:10.1373/49.4.594 · Cited by 40
Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins
de Munter, W., Geven, E. J., Blom, A. B., Walgreen, B., Helsen, M. M., Joosten, L. A. B., Roth, J., Vogl, T., van de Loo, F. A. J., Koenders, M. I., et al. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.07.020 · Cited by 39
Human S100A9 potentiates IL‐8 production in response to GM‐CSF or fMLP via activation of a different set of transcription factors in neutrophils
Simard, J.-C., Noël, C., Tessier, P. A., & Girard, D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.027 · Cited by 38
Loss of Myeloid Related Protein-8/14 Exacerbates Cardiac Allograft Rejection
Shimizu, K., Libby, P., Rocha, V. Z., Folco, E. J. E., Shubiki, R., Grabie, N., Jang, S., Lichtman, A. H., Shimizu, A., Hogg, N., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.009910 · Cited by 38
Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
Nyalwidhe, J. O., Grzesik, W. J., Burch, T. C., Semeraro, M. L., Waseem, T. C., Gerling, I., Mirmira, R. G., Morris, M. A., & Nadler, J. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183908 · Cited by 37
Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae
Swathi Raju, M., Jahnavi, V. S., Kamaraju, S. R., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A., & Burgula, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5112 · Cited by 36
Expression and Function of S100A8/A9 (Calprotectin) in Human Typhoid Fever and the Murine Salmonella Model
de Jong, H. K., Achouiti, A., Koh, G. C. K. W., Parry, C. M., Baker, S. G., Faiz, M. A., van Dissel, J. T., Vollaard, A. M., van Leeuwen, E. M. M., Roelofs, J. J. T. H., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003663 · Cited by 35
Proinflammatory effects and mechanisms of calprotectin on human gingival fibroblasts
Gao, H., Hou, J., Meng, H., Zhang, X., Zheng, Y., & Peng, L. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12465 · Cited by 35
Calgranulins May Contribute Vascular Protection In Atherogenesis
Geczy, C. L., Chung, Y. M., & Hiroshima, Y. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1505 · Cited by 32
Inflammatory peritoneal reaction after perforated appendicitis: continuous peritoneal lavage versus non lavage.
Schwarz, A., Bölke, E., Peiper, M., Esch, J. S. A., Steinbach, G., van Griensven, M., & Orth, K. (2007) · PubMed · Cited by 32
Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung
Cohen, J., & Larson, J. E. (2005) · BMC Developmental Biology · doi:10.1186/1471-213x-5-2 · Cited by 31
Elevated levels of serum MRP8/14 in ankylosing spondylitis: associated with peripheral arthritis and active disease
Gupta, L., Bhattacharya, S., Agarwal, V., & Aggarwal, A. (2016) · Clinical Rheumatology · doi:10.1007/s10067-016-3448-x · Cited by 31
Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia
Achouiti, A., Vogl, T., van der Meer, A. J., Stroo, I., Florquin, S., de Boer, O. J., Roth, J., Zeerleder, S. S., Veer, C. V. ′., de Vos, A. F., et al. (2015) · European Respiratory Journal · doi:10.1183/09031936.00183814 · Cited by 30
High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density
Hirata, A., Kishida, K., Nakatsuji, H., Hiuge-Shimizu, A., Funahashi, T., & Shimomura, I. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.01.026 · Cited by 29
S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
Chimenti, M. S., Triggianese, P., Botti, E., Narcisi, A., Conigliaro, P., Giunta, A., Teoli, M., Perricone, R., & Costanzo, A. (2016) · Journal of International Medical Research · doi:10.1177/0300060515598900 · Cited by 29
Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils
McNeill, E., Conway, S. J., Roderick, H. L., Bootman, M. D., & Hogg, N. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.05.004 · Cited by 28
Advanced glycation end products increase expression of S100A8 and A9 via RAGE – MAPK in rat dental pulp cells
Nakajima, Y., Inagaki, Y., Kido, J., & Nagata, T. (2014) · Oral Diseases · doi:10.1111/odi.12280 · Cited by 28
Chronic Pseudomonas aeruginosa Biofilm Infection Impairs Murine S100A8/A9 and Neutrophil Effector Cytokines – Implications for Delayed Wound Closure?
Trøstrup, H., Lerche, C. J., Christophersen, L., Thomsen, K., Jensen, P. Ø., Hougen, H. P., Høiby, N., & Moser, C. E. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx068 · Cited by 27
Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
Reichman, H., Moshkovits, I., Itan, M., Pasmanik-Chor, M., Vogl, T., Roth, J., & Munitz, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-07738-z · Cited by 27
S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle
Xu, Y., Wang, Y., Yin, L.-M., Park, G., Ulloa, L., & Yang, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.033 · Cited by 26
Differential Association of S100A9, an Inflammatory Marker, and p53, a Cell Cycle Marker, Expression with Epicardial Adipocyte Size in Patients with Cardiovascular Disease
Agra, R. M., Fernández‐Trasancos, Á., Sierra, J. C., González‐Juanatey, J. R., & Eiras-Penas, S. (2014) · Inflammation · doi:10.1007/s10753-014-9876-3 · Cited by 23
Augmentation of Epithelial Resistance to Invading Bacteria by Using mRNA Transfections
Zou, X., Sorenson, B. S., Ross, K. F., & Herzberg, M. C. (2013) · Infection and Immunity · doi:10.1128/iai.00539-13 · Cited by 23
Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation
Takama, H., Sugiura, K., Ogawa, Y., Muro, Y., & Akiyama, M. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.04.007 · Cited by 21
Myeloid-Related Protein-14/MRP-14/S100A9/Calgranulin B is Associated with Inflammation in Proliferative Diabetic Retinopathy
El‐Asrar, A. M. A., Alam, K., Siddiquei, M. M., den Eynde, K. V., Mohammad, G., Hertogh, G. D., & Opdenakker, G. (2016) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2016.1245759 · Cited by 20
Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity
Zhu, Q., Li, F., Wang, J., Ma, J., & Sheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.16954 · Cited by 19
Self-citation
Obesity Corrupts Myelopoiesis
Murray, P. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.010 · Cited by 15
Characterization of Cell Growth‐Inhibitory Factor in Inflammatory Peritoneal Exudate Cells of Rats
Yui, S., Yang, D., Mikami, M., & Yamazaki, M. (1993) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1993.tb01730.x · Cited by 14
The accumulation of macrophages expressing myeloid-related protein 8 (MRP8) and MRP14 in the spleen of BALB/cA mice during infection with Plasmodium berghei
Mizobuchi, H., Yamakoshi, S., Omachi, S., Osada, Y., Sanjoba, C., Goto, Y., & Matsumoto, Y. (2014) · Experimental Parasitology · doi:10.1016/j.exppara.2014.01.003 · Cited by 14
Myeloid-related protein-8/14 is associated with proinflammatory cytokines in cervical mucus
Kunimi, K., Maegawa, M., Kamada, M., Yamamoto, S., Yasui, T., Matsuzaki, T., Kuwahara, A., Furumoto, H., Ohmoto, Y., Kido, H., et al. (2006) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2005.12.010 · Cited by 14
Immunodetection of the murine chemotactic protein CP-10 in bleomycin-induced pulmonary injury
Kumar, R. K., Harrison, C. A., Cornish, C. J., Kocijer, M., & Geczy, C. R. (1998) · Pathology · doi:10.1080/00313029800169665 · Cited by 13
S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis
Başsorgun, C. İ., Ünal, B., Erin, N., Özlük, A. A., Uzun, Ö. C., & Elpek, G. Ö. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/943175 · Cited by 12
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis
Tanigawa, H., Miyata, K., Tian, Z., Aoi, J., Kadomatsu, T., Fukushima, S., Ogata, A., Takeda, N., Zhao, J., Zhu, S., et al. (2016) · Scientific Reports · doi:10.1038/srep34690 · Cited by 12
Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
Алексеевна, Г. М., Davydova, T. V., Fomina, V. G., Vetrilé, L. A., Morozova‐Roche, L. A., & Sewell, R. D. E. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3632-2 · Cited by 11
Differential proteomics of monosodium urate crystals‐induced inflammatory response in dissected murine air pouch membranes by iTRAQ technology
Chiu, C., Chen, H., Wu, T., Shih, Y., Huang, K., Tsai, Y., Hsu, Y., & Chen, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400626 · Cited by 10
Time-dependent expression of leukotriene B4 receptors in rat collagen-induced arthritis
Han, C., Huang, H., Hu, M., Wang, Q., Gao, Y., & Liu, Y. (2007) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2007.01.011 · Cited by 10
The S100A8-serum amyloid A3-LOX-1 cascade in atherosclerotic plaque rupture
Wang, Y., & Xu, D. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.11.082 · Cited by 2
好中球からの広範囲アポトーシス誘導活性を有する炎症性蛋白質複合体calprotectin(S100A8/S100A9)(Calprotectin (S100A8/S100A9),an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity)
Satoru, Y., Yuichi, N., & Masaaki, M. (2003) · Institutional Repositories DataBase (IRDB) · doi:10.1248/bpb.26.753

Flagged first, then by citations

Sorted by citations

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
Silvin, A., Chapuis, N., Dunsmore, G., Goubet, A.-G., Dubuisson, A., Derosa, L., Almire, C., Hénon, C., Kosmider, O., Droin, N., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.002 · Cited by 834
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0939-8 · Cited by 740
Sexual-dimorphism in human immune system aging
Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Cervia, C., Brüningk, S. C., Hoch, T., Fan, B., Muzio, G., Thompson, R. C., Ceglarek, L., Meledin, R., Westermann, P., Emmenegger, M., et al. (2024) · Science · doi:10.1126/science.adg7942 · Cited by 437
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist, N., Muirhead, G., Prast‐Nielsen, S., Jeanmougin, M., Oláh, P., Skoog, T., Jules-Clément, G., Feld, M., Barrientos‐Somarribas, M., Sinkko, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12253-y · Cited by 419

See all 1,450

Authors: Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
Affiliations: Central South University (CN)
Corresponding author: Ma, Jian
ORCID: Wang, Siwen
Song, Rui
Wang, Ziyi
Jing, Zhaocheng
Wang, Shaoxiong
Ma, Jian
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-06-11
Volume: 9
Pages: 1298-1298
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.01298
PMC: PMC6004386
OpenAlex: W2808305854
Cited by: 1,450
References: 165
Citations by year: 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672889, 81472694)
Hunan Provincial Science and Technology Department (2016JC2035)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
MeSH terms: Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

S100A8/A9 in Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks